A5013032117- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Optical Imaging and Spectroscopy Techniques
Cincinnati Children's Hospital Medical Center
2021-2022
Infants born very preterm (VPT) are at high risk of motor impairments such as cerebral palsy (CP), and diagnosis can take 2 years. Identifying in vivo determinants CP could facilitate presymptomatic detection targeted intervention. Our objectives were to derive micro- macrostructural measures sensorimotor white matter tract integrity from diffusion MRI term-equivalent age, determine their association with early CP. We enrolled 263 VPT infants (≤32 weeks gestational age) part a large...
Infants born very preterm (VPT) are at risk of later visual problems. Although neonatal screening can identify ophthalmologic abnormalities, subtle perinatal brain injury and/or delayed maturation may be significant contributors to complex visual-behavioral Our aim was assess the micro and macrostructural antecedents early difficulties in VPT infants by using diffusion MRI (dMRI) term-equivalent age. We prospectively recruited a cohort 262 (≤32 weeks gestational age [GA]) from five intensive...