We develop a novel approach to energy-efficient transmissions with arbitrary packet arrival process and strict delay constraints over time-varying wireless channels. When the arrivals, deadlines, channel realizations are known priori, we formulate problem as convex program. Relying on specific structure of optimality conditions, put forth an efficient algorithm linear computational complexity in order constraint number find (offline) optimal rate control strategy. It is revealed that power...

Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed synthesized. Compound 4a is the first organic micromolecule to kill tumor cells by only paraptosis, its mechanism of action has been further explored. Paraptosis does not appear involve either phosphatidylserine translocation associated with apoptosis or cycle arrest. The bisbenzyloxy N-(2-hydroxyethyl)formamide structures may be two critical pharmacophores for paraptosis. Bisbenzyloxy can...

Cytoplasmic epidermal growth factor receptor (EGFR) is overexpressed in both nasopharyngeal carcinoma (NPC) and triple-negative breast cancer (TNBC), while clinical outcome prognosis vary greatly among patients treated with gefitinib, all eventually develop resistance to this agent. Therefore, we propose a new concept for synthesizing multitarget compounds reveal therapeutic strategies NPC TNBC expressing EGFR. Compound H was synthesized our previous study. Molecular docking cell thermal...

Open‐cell AlSi foams with varying cell sizes and pore structures are fabricated using infiltration casting. Foams uniform ranging from 2.0 to 4.0 mm 1.5 exhibit typical open‐cell walls. In contrast, a foam mixed size distribution (1.5 mm) demonstrates improved connectivity but exhibits more structural defects. Quasistatic uniaxial compression tests performed evaluate the compressive behavior of foams. The deformation process energy absorption mechanisms three comprehensively analyzed...

In this paper, we consider the adaptive subcarrier assignment and fair power control strategy that minimize a cost function of average relay powers for multiuser wireless orthogonal frequency-division multiplexing (OFDM) networks, where set relays assists communication between sources destinations with an amplify-and-forward strategy. Using class β-fair functions to balance tradeoff energy efficiency fairness, joint optimal power-allocation schemes at are derived in quasi-closed form....

Abstract. A total of 25 flexural and 55 uniaxial compressive strength tests were conducted in laboratory using landfast sea ice samples collected the Prydz Bay. Three-point bending performed at temperatures −12 to −3 ∘C with force applied vertically original surface, a strain-rate level 10−6–10−2 s−1 directions vertical horizontal surface. Judging from crystal structure, divided into congelation ice, snow mixture two. The results showed that had decreasing trend depending on porosity rather...

In this paper, we consider joint congestion control and wireless-link scheduling design for TCP applications over the Internet with ad-hoc wireless links. Differing from existing methods, main idea of our approach is to develop non-standard window-based implicit primal-dual solver intended optimization problem. Then queueing delays are employed decompose into local algorithms that can be deployed operated asynchronously at different layers network nodes. Capitalizing on approach, put forth...

Aim: The EGF receptor (EGFR) is overexpressed in multiple epithelial-derived cancers and considered to be a vital target closely associated with cancer therapy. In this study, series of novel anthraquinone−quinazoline hybrids targeting several sites for therapy were designed synthesized. Methodology & results: Most the synthesized demonstrated excellent antiproliferative activity downregulation expression EGFR. most promising compound 7d showed strongest antiproliferation activity;...

We consider joint congestion control and wireless link-scheduling design for mobile TCP applications. Adopting queueing delay as the measure, we show that optimal link scheduling scheme amounts to window-control oriented implicit primal-dual solvers underlying network utility maximization. Based on this idea, develop readily deployable, scalable yet schemes Internet with coupled links, provided access point performs a queueing-delay based scheduling. Global convergence/stability of proposed...

This paper considers the jointly optimal rate and power allocation that maximizes a utility function of average rates in fading OFDMA multiple access broadcast channels. Derived under assumption superposition coding is allowed per subcarrier, proposed low-complexity (yet capacity-achieving) resource scheme can yield higher achievable than existing approaches based on exclusive subcarrier assignment. In addition, relying stochastic optimization tools, we develop class gradient iterations are...

Relying on a design-space oriented cross-layer optimization approach, we develop joint TCP congestion control and CSMA scheduling schemes for mobile applications over Internet with distributed multi-hop wireless links. Different from the existing solutions, proposed can be asynchronously implemented without message passing among network nodes. Confined to design space of CSMA, they are readily deployed current infrastructure. Moreover, global convergence/stability optimal equilibrium is...

In this paper, we propose that the keys to Internet cross-layer optimization are development of nonstandard implicit primal-dual solvers for underlying problems, and design jointly optimal network protocols as decomposition such solvers. Relying on novel approach, develop joint TCP congestion control wireless-link scheduling schemes wireless applications over with centralized distributed (multi-hop) links. Different from existing solutions, proposed can be asynchronously implemented without...

Enzyme-mediating biotransformations commonly occur in micro- and nanospace, which is crucial to maintain the essential biochemical processes physiological functions living systems. Probing enzyme-catalytic reactions a biomimetic fashion remains challenging due lack of competent tools methodology. Here, we show that studying enzymatic reaction kinetics can be readily achieved by well-designed solid-state nanopore. Using tyrosine as classical substrate, quantitatively characterize catalytic...

Abstract. A total of 25 flexural and 55 uniaxial compressive strength tests were conducted using landfast sea ice samples collected in the Prydz Bay. Three-point bending performed at temperatures −12 to −3 °C with force applied vertically original surface, a strain-rate level 10−6–10−2 s−1 directions vertical horizontal surface. Judging from crystal structure, divided into congelation ice, snow mixture these two. The results showed that had decreasing trend depending on porosity rather than...

We consider adaptive subcarrier assignment and fair power control strategy that minimizes a cost function of average relay powers for multi-user wireless OFDM networks, where relays assist communication between sources destinations with an amplify-and-forward strategy. Using class beta-fair functions to balance the tradeoff energy efficiency fairness, jointly optimal allocation schemes at are derived in quasi-closed form. In addition, we develop novel stochastic optimization algorithms...

A monotonic optimization approach to downlink beamforming is developed maximize the weighted sum of user rates. After formulating problem as a program (MP), polyblock outer approximation algorithm devised construct nested sequence polyblocks, and search for optimal MP solution among vertices these polyblocks. In context, construction such polyblocks enabled by solving series signal-to-interference-plus-noise ratio (SINR) balancing problems. Leveraging uplink-downlink duality, efficient...

This paper considers the jointly optimal rate and power allocation that maximizes a utility function of average rates in fading OFDMA broadcast channels. Derived under assumption superposition coding is allowed per subcarrier, proposed low-complexity (yet capacity-achieving) resource scheme can yield higher achievable than existing approaches based on exclusive subcarrier assignment. In addition, relying stochastic optimization tools, we develop class gradient iterations are capable...

This paper considers the jointly optimal rate and power allocation that maximizes a utility function of average rates in OFDMA multiple access broadcast channels. Derived under assumption superposition coding is allowed per subcarrier, our low-complexity (yet capacity-achieving) resource scheme can yield higher achievable than existing approaches based on exclusive subcarrier assignment. In addition, relying stochastic optimization tools, we develop class gradient iterations are capable...