A5087554974- Economic and Environmental Valuation
- Global Maternal and Child Health
- Health Systems, Economic Evaluations, Quality of Life
- Vaccine Coverage and Hesitancy
- Autoimmune Neurological Disorders and Treatments
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Sex work and related issues
- Myasthenia Gravis and Thymoma
- Ubiquitin and proteasome pathways
Yale University
2020-2022
Western University
2019
The multi-subunit C-terminal to LisH (CTLH) complex is the mammalian homologue of yeast Gid E3 ubiquitin ligase complex. In this study, we investigated human CTLH and characterized its activity. We confirm that immunoprecipitated from cells comprises RanBPM, ARMC8 α/β, muskelin, WDR26, GID4 RING domain proteins RMND5A MAEA. find loss expression individual subunits compromises stability other members MAEA protein levels are interdependent. Using in vitro ubiquitination assays, demonstrate has...
Objective To explore how respondents with common chronic conditions—hypertension (HTN) and diabetes mellitus (DM)—make healthcare-seeking decisions. Setting Three health facilities in Nakaseke District, Uganda. Design Discrete choice experiment (DCE). Participants 496 adults HTN and/or DM. Main outcome measures Willingness to pay for changes DCE attributes: getting the facility, interactions healthcare providers, availability of medicines condition, patient peer-support groups; education at...
BackgroundIn 2020, non-communicable diseases (NCDs) currently account for 40% of deaths in east Africa and are expected to surpass communicable as the leading causes death sub-Saharan by 2030. However, there remain many gaps provision high quality, patient-centred NCD service delivery low-income countries such Uganda, especially rural settings. We developed a discrete choice experiment (DCE) understand how patients with common NCDs, hypertension diabetes, make health-care-seeking decisions....
Abstract A discrete choice experiment (DCE) is a method to quantify preferences for goods and services in population. Participants are asked choose between sets of 2 hypothetical scenarios that differ terms particular characteristics. Their selections reveal the relative importance each “attribute”, or characteristic, extent which people consider trade-offs DCEs increasingly used healthcare public health settings as they can inform design health-related interventions achieve maximum impact....
Background Cisgender female sex workers (FSWs) in sub-Saharan Africa have a high risk of HIV acquisition, highlighting the need for innovative approaches to expand coverage evidence-based prevention methods, including oral pre-exposure prophylaxis (PrEP). Our study aimed identify FSWs’ preferences PrEP delivery model with structured choices location, services offered, and adherence support. Methods We conducted discrete choice experiment (DCE) among FSWs ≥18 years recruited from Most At-Risk...
Lambert-Eaton Myasthenic Syndrome (LEMS) is a neuromuscular junction defect that results in weakness. It rarely seen children and most commonly associated with small-cell lung cancer. Diagnosis of LEMS requires characteristic electromyogram (EMG) findings the detection antibodies directed against voltage-gated calcium channels. We report case an 8-year-old female child who presented profound weakness found to have EMG evidence detectable antivoltage-gated channel antibodies. She received...