A5013748247- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Visual perception and processing mechanisms
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Photoreceptor and optogenetics research
- Ophthalmology and Visual Impairment Studies
- Circadian rhythm and melatonin
- Ocular and Laser Science Research
- Retinal and Optic Conditions
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Retinal and Macular Surgery
- Cerebral Venous Sinus Thrombosis
- Color Science and Applications
- Color perception and design
- Sleep and related disorders
- Multisensory perception and integration
- Tactile and Sensory Interactions
- Neural and Behavioral Psychology Studies
- Olfactory and Sensory Function Studies
- Ocular Disorders and Treatments
- Advanced Glycation End Products research
- Systemic Lupus Erythematosus Research
- Sleep and Wakefulness Research
University of Illinois Chicago
2016-2025
University of Virginia
2024
University of Illinois Urbana-Champaign
2014-2023
Visual Sciences (United States)
2017-2020
Abstract The pattern electroretinogram (PERG) is a localized retinal response evoked by contrast-reversing pattern, usually black and white checkerboard, which provides information about macular ganglion cell function. This document, from the International Society for Clinical Electrophysiology of Vision (ISCEV; www.iscev.org ) presents an updated revised Standard clinical PERG testing. replaces 2013 all earlier versions. Minimum protocols basic stimuli, recording methods reporting are...
The International Society for Clinical Electrophysiology of Vision (ISCEV) Standard full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol an extension to the ERG Standard, namely photopic negative response (PhNR) light-adapted flash ERG, as well-established technique that is broadly accepted by experts in field. PhNR slow negative-going wave after b-wave provides information about function retinal ganglion...
Purpose.: We determined the relative contributions of rods, cones, and melanopsin to pupil responses in humans using temporal sinusoidal stimulation for light levels spanning low mesopic photopic range. Methods.: A four-primary Ganzfeld photostimulator controlled flicker stimulations at seven (−2.7 2 log cd/m2) five frequencies (0.5–8 Hz). Pupil diameter was measured a high-resolution eye tracker. Three kinds photoreceptor modulations were generated silent substitution: rod modulation, cone...
Abstract The goal of this study was to determine the extent rod-, cone-, and melanopsin-mediated pupillary light reflex (PLR) abnormalities in diabetic patients who have non-proliferative retinopathy (NPDR). Fifty subjects different stages NPDR 25 age-equivalent, non-diabetic controls participated. PLRs were measured response full-field, brief-flash stimuli under conditions that target rod, cone, intrinsically-photosensitive (melanopsin) retinal ganglion cell pathways. Pupil responses...
SIGNIFICANCE The response of the pupil to a flash light, pupillary light reflex (PLR), is an important measure in optometry and other fields medicine that typically evaluated by qualitative observation. Here we describe simple, portable, iPhone-based pupillometer quantifies PLR real time. PURPOSES purposes this study were novel application records compare its technical capabilities with laboratory-based infrared (IR) camera system. METHODS Pupil sizes measured from 15 visually normal...
Purpose: To define the nature and extent of cone photoreceptor abnormalities in diabetic individuals who have mild or no retinopathy by assessing activation phase phototransduction flicker ERG these individuals. Methods: Light-adapted single-flash ERGs were recorded from 20 clinically apparent (NDR), nonproliferative (NPDR), nondiabetic, age-equivalent controls. A-waves elicited flashes different retinal illuminance fit with a delayed Gaussian model to derive Rmp3 (maximum amplitude massed...
This study determined if the pupillary light reflex (PLR) driven by brief stimulus presentations can be accounted for product of luminance and area (i.e., corneal flux density, CFD) under conditions biased toward rod, cone, melanopsin pathways. Five visually normal subjects participated in study. Stimuli consisted 1-s short- long-wavelength flashes that spanned a large range angular subtense. The stimuli were presented central visual field dark (rod conditions) against rod-suppressing...
To evaluate changes in visual acuity (VA) over time patients with Leber congenital amaurosis (LCA) and mutations the CEP290 gene.Visual was determined at initial most recent visits of 43 LCA mutations. The main outcome measures included best-corrected VA visits, as well correlation between age VA.At visit, 14 had measurable chart better-seeing eye, 25 nonmeasurable VA, 4 young did not have assessed. At 15 28 VA. average interval 2 10.4 years (range, 2-47 years). For median logMAR value visit...
Alzheimer disease (AD) is the most prevalent cause of dementia in elderly. Although impaired cognition and memory are prominent features AD, abnormalities visual functions often precede them, increasingly being used as diagnostic prognostic markers for disease. Retina contains highest concentration essential fatty acid docosahexaenoic (DHA) body, its deficiency associated with several retinal diseases including diabetic retinopathy age related macular degeneration. In this study, we tested...
Purpose: To provide a quantitative assessment of the primary retinal layers affected by macular cystoid spaces in X-linked retinoschisis (XLRS) and enhanced S-cone syndrome (ESCS). Methods: Twenty-two visually-normal controls, 14 XLRS 7 ESCS (autosomal recessive inheritance) subjects participated. Macular B-scans were acquired OCT thickness inner-nuclear layer (INL), outer-nuclear plus outer-plexiform (OPL+ONL), photoreceptor outer segments (OS+) was calculated. ANOVA used to compare mean...
: To determine the value of a topical carbonic anhydrase inhibitor on macular thickness and function in choroideremia patients with cystoid edema.: Two edema, observed by spectral-domain optical coherence tomography, were treated form inhibitor. Examinations performed before during treatment included best-corrected visual acuity using Early Treatment Diabetic Retinopathy Study charts contrast sensitivity measured briefly presented grating targets Pelli-Robson letter chart, microperimetry,...
Purpose.: To evaluate the photopic negative response (PhNR) as an index of retinal ganglion cell (RGC) function in idiopathic intracranial hypertension (IIH). Methods.: Amplitude and implicit time PhNR, elicited by full-field, brief-luminance flashes, was measured IIH (n = 10) visually normal control 15) subjects. Visual assessed subjects using standard automated perimetry mean deviation (SAP-MD) scores. Optic nerve structure evaluated Frisén papilledema grading scale (FPG). Macula complex...
To evaluate the effects of idiopathic intracranial hypertension (IIH) on rod-, cone-, and melanopsin-mediated pupillary light reflexes (PLRs).Pupillary elicited by full-field, brief-flash stimuli were recorded in 13 IIH patients normal controls. Subjects dark-adapted for 10 minutes PLR was response to short-wavelength flashes (0.001 cd/m2: rod condition; 450 melanopsin condition). then exposed a rod-suppressing field cd/m2 long-wavelength presented (cone Pupillary quantified as maximum...
Purpose: To investigate visual function in patients with CEP290 Leber congenital amaurosis (LCA-CEP290), using three full-field tests that can be performed by poor fixation. Methods: Six (age range, 9–39 years) LCA-CEP290 participated the study. Stimuli for all (full-field stimulus test [FST], pupillometry, and light discomfort threshold [LDT] testing) were generated Diagnosys ColorDome ganzfeld, achromatic stimuli as well long- short-wavelength to target rod cone photoreceptors and, latter...
To determine the relationship between contrast sensitivity (CS) and outer-retina thickness (ORT) in diabetics who have minimal or no diabetic retinopathy (DR).Twenty non-diabetic control subjects 40 type-2 participated (20 had clinically apparent DR [NDR] 20 mild non-proliferative [NPDR]). No subject a history of treatment for macular oedema. Letter CS, microperimetry (MP) visual acuity (VA) were measured. CS MP measurements performed over central 6° field. Spectral domain optical coherence...
Purpose To evaluate the relationship between microperimetric (MP) sensitivity and retinal thickness measured at co-registered locations in individuals who have mild or no diabetic retinopathy.Methods Fifty non-diabetic control subjects 50 type-2 participated (25 had clinically apparent DR [NDR] 25 nonproliferative [MDR]). MP was 36 that were arranged three concentric rings centered on fovea (radii of 3°, 6°, 12°). Optical coherence tomography (OCT) images obtained, total (TRT), inner (IRT),...
Intrinsically photosensitive retinal ganglion cells (ipRGCs) control non-visual light responses (e.g. pupillary reflex and circadian entrainment). Patients with diabetic retinopathy (DR) show reduced ipRGC function, as inferred by abnormalities in the post illumination pupil response (PIPR). We explored whether function DR is associated outputs sleep/wake behavior.Forty-five participants (15 without diabetes, 15 type 2 diabetes (T2D) no DR, T2D DR) participated. was from PIPR (pupil size...