A5088437347- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Urological Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- 3D Printing in Biomedical Research
- Renal and related cancers
- Quinazolinone synthesis and applications
- Protein Degradation and Inhibitors
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Hematological disorders and diagnostics
- Bladder and Urothelial Cancer Treatments
- Wnt/β-catenin signaling in development and cancer
- Corneal Surgery and Treatments
- Polyomavirus and related diseases
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2014-2018
University of Brescia
2011-2018
Università Cattolica del Sacro Cuore
2016
European Institute of Oncology
2016
Agostino Gemelli University Polyclinic
2016
Vita-Salute San Raffaele University
2015
San Raffaele University of Rome
2015
Dulbecco Telethon Institute
2008
Uromodulin is the most abundant protein in urine. It exclusively produced by renal epithelial cells and it plays key roles kidney function disease. mainly exerts its as an extracellular matrix whose assembly depends on a conserved, specific proteolytic cleavage leading to conformational activation of Zona Pellucida (ZP) polymerisation domain. Through comprehensive approach, including extensive characterisation uromodulin processing cellular models knock-out mice, we demonstrate that...
Uromodulin is the most abundant protein secreted in urine, which it found as a high-molecular-weight polymer. Polymerization occurs via its zona pellucida (ZP) domain, conserved module shared by many extracellular eukaryotic proteins that are able to assemble into matrices. In this work, we identified two motifs uromodulin, mapping linker region of ZP domain and between cleavage glycosylphosphatidylinositol (GPI)-anchoring sites, regulate polymerization. Indeed, mutations either led...
Extracorporeal photopheresis (ECP) is considered a valid second-line treatment for acute and chronic graft versus host disease (GVHD).Ninety-four patients with GVHD (aGVHD) (n = 45) (cGVHD) 49), retrospectively recruited in 6 Italian centers, were submitted to ECP treatment. At the time of ECP, 22 (49%) 23 (51%) 45 aGHVD nonresponsive partial remission (PR) after steroids, respectively, all 49 cGVHD steroid refractory.Forty-one (91%) aGVHD achieved complete (CR) ECP. Fifteen (33%) developed...
A human bone marrow-derived mesenchymal stromal cell (MSCs) and cord blood-derived CD34+ stem co-culture system was set up in order to evaluate the proliferative differentiative effects induced by MSCs on cells, reciprocal influences gene expression profiles. After 10 days of co-culture, non-adherent (SN-fraction) adherent (AD-fraction) cells were collected analysed separately. In presence MSCs, a significant increase number observed (fold = 14.68), mostly SN-fraction 13.20). This combined...
To evaluate if WT1 expression may predict relapse after allo-SCT, we analyzed levels on peripheral blood (PB) and bone marrow (BM) before allo-SCT in 24 AML patients with overexpression at diagnosis. Five copies of WT1/ABL × 10 4 from PB were identified as the threshold value that correlated allo-SCT. The same correlation was not when assessed (BM). Eight out 11 (73%) a pre-allo-SCT PB-WT1 ≥ 5 4/13 (31%) < relapsed, respectively ( P = 0.04). incidence higher measured 3rd (56% versus 38%;...
Philadelphia-positive (Ph+), BCR-ABL1, chronic myeloid leukemia (CML) is a model of driven by single, specific, chromosome translocation, the t (9;22) (q22;q11). This leading to new, hybrid, leukemia-specific gene (BCR-ABL1) encoding for deregulated tyrosine-kinase protein (p210), drives leukemic transformation hematopoietic stem cells [1-6] and induces progression disease from early phase (CP) late blastic BP) which close natural history disease. In 2000s, introduction Imatinib, first...
T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) relapse of hematological malignancies after stem cell transplantation (SCT). Their sequential assessment together with neogenesis indexes has thoroughly analysed in relation these changing interrelated immunologic/clinic events yet. Lymphocyte peripheral blood (PB) were at different time points a prospective study 50 patients. Principal component analysis (PCA) was used as first step...
Toll-like receptors (TLRs) play a key role in the cross-talk between innate and adaptive immune systems. Previous studies investigating associations certain TLRs acute graft-versus-host disease (aGVHD) have reported contrasting results, no relating aGVHD to expression function of all human together been published date. We prospectively evaluated 9 on T lymphocytes monocytes by flow cytometry relation 34 patients. Induction TNF-α, IL-4, IFN-γ, monocyte chemotactic protein 1 TLR activation was...
Abstract Background Bacterial, fungal, and viral infections often affect non‐relapse mortality after allogeneic stem cell transplantation (allo SCT ). Recovery from depends on a balanced integration between innate adaptive immune responses. In this complex interplay, key role is played by Toll‐like receptors ( TLR s), which are sensors of pathogen‐associated molecular patterns. To our knowledge, no previous study deals with both expression function all human s together, in relation to the...