A5050165455- Monoclonal and Polyclonal Antibodies Research
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Advanced Biosensing Techniques and Applications
- Ophthalmology and Visual Impairment Studies
- Nanofabrication and Lithography Techniques
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Folate and B Vitamins Research
- Anesthesia and Neurotoxicity Research
- Intraocular Surgery and Lenses
- Genomics and Rare Diseases
- Sperm and Testicular Function
- Ubiquitin and proteasome pathways
- Ocular Surface and Contact Lens
- Genetics and Neurodevelopmental Disorders
- Biosimilars and Bioanalytical Methods
- Viral Infectious Diseases and Gene Expression in Insects
- Pelvic floor disorders treatments
- T-cell and B-cell Immunology
- Retinal and Optic Conditions
- Anesthesia and Sedative Agents
- earthquake and tectonic studies
Children's Hospital of Fudan University
2022-2025
China Geological Survey
2020
Nanfang Hospital
2011-2013
Southern Medical University
2011-2013
Eye & ENT Hospital of Fudan University
2013
Institute of Ophthalmology
2013
<h3>Aim</h3> To evaluate and compare early corneal wound healing inflammatory responses after small incision lenticule extraction (SMILE) versus femtosecond laser in situ keratomileusis (LASIK). <h3>Methods</h3> Thirty-six eyes of 36 rabbits underwent SMILE, while another were treated with LASIK. All the subjected to same refractive correction −6.00 DS/−1.00 DC. Twelve that had no surgery included for control. After euthanisation, tissue sections evaluated terminal deoxyribonucleotidyl...
Coronavirus disease 2019 (COVID-19) has been coexisted with us, and corticosteroids are now recommended for patients severe COVID-19 respiratory failure. Steroid treatments may increase intraocular pressure (IOP) steroid-induced glaucoma (SIG). This study reported a rapid IOP elevation in pneumonia child treated systemic steroids within 3 days. Steroid-induced ocular hypertension (SIOH) during treatment not previously reported. The 6-year-old Chinese girl was diagnosed presented pulmonary...
Abstract Purpose To determine the pattern of axial variation in subjects with initial shortened length during entire period orthokeratology and to discuss possibility AL after one month becoming a predictor myopia control. Method This study retrospectively included 106 children aged 8 14 wearing OK lenses. Fifty-four eyes (AL) at first-month visit were enrolled shortening (ALS) group, fifty-two without no (NALS) group. Axial refractive error baseline within (20 months), including fitting,...
The display of full-length antibody on the cell surface was achieved by fusing a transmembrane domain platelet-derived growth factor receptor (PDGFR) to C-terminus heavy chain constant region. We also incorporated furin cleavage site between region and PDGFR obtain secreted antibodies. As result, antibodies can be expressed simultaneously in membrane-anchored version for screening selecting through fluorescence-activated sorting (FACS) analysis, as well conditioned medium function analysis.
Background: Shashi-Pena syndrome (SHAPNS) is a developmental disorder caused by mutations in additional sex combs-like Protein 2 (ASXL2). Since 2016, only 12 cases from 10 families have been reported. However, neonatal period characteristics remain largely unknown. Herein, we report case with pathogenic variant ASXL2 newborn. Case Description: A newborn was diagnosed previously unreported de novo truncating mutation (NM_018263.6) at 21 days and the clinical of all probands ASXL2-related...
A unique four-way ligation strategy was developed for rapid construction of a full-length antibody library. mammalian expression vector constructed that contained dual cassettes and sequences recognized by the restriction enzymes BsmBI, BstXI, SfiI. Both light-chain variable domain heavy-chain genes were inserted into in one step ligation, bivalent antibodies displayed on cell surfaces. Using this strategy, only 2 weeks required to successfully construct high-quality, human libraries.
Purpose. To identify the potential key genes and molecular pathways associated with keratoconus allergic disease. Methods. The pubmed2ensembl database was used to text mining (TMGs) collectively involved in GeneCodis program perform Gene Ontology (GO) biological process Kyoto Encyclopedia of Genes Genomes (KEGG) pathway enrichment analysis TMGs. protein-protein interaction (PPI) network TMGs established by STRING; significant gene modules hub PPI were further performed using Cytoscape...
Abstract A‐type granites, as an important petrologic sign to build up environmental recognition, were mainly formed in extensional tectonic settings. A biotite syenogranite from the Fenghuangshan pluton Dandong, Liaoning Province gave SHRIMP zircon U‐Pb ages of 122.5 ± 1.6 Ma, 124.9 1.7 Ma and 126.9 1.1 Ma. The monzogranites have 118.2 128.1 131.6 1.9 giving emplacement age for Early Cretaceous. SiO 2 is 65.48–74.49 wt%, whereas that K O 4.16–6.44 Na 2.99–4.70 wt%. They also contain...
PurposeAmbulatory surgery (same-day or day surgery) is an efficient medical practice. However, there were few reports regarding the safety of ophthalmic ambulatory for children under general anesthesia. This study aims to explore its clinical complications.DesignA retrospective observational study.MethodsThe data pediatric patients who received anesthesia at Children's Hospital Fudan University from January 2015 December 2019 analyzed retrospectively. Postoperative complications, unplanned...
Objective To evaluate the changes of retinal nerve fiber layer and macular parameters after femtosecond laser-assisted laser in situ keratomileusis (fs-LASIK) assessed by spectral-domain optical coherence tomography (SD-OCT).Methods This prospective,consecutive study included 17 patients (33 eyes) with high (greater than-6.00 D) myopia treated fs-LASIK.The thickness volume RNFLT measurements were performed using RTVue-100 OCT preoperatively then on 1 day,1 week month postoperation.The before...
Abstract Purpose : To determine the pattern of axial variation in subjects with initial shortened length during entire period orthokeratology and to discuss possibility AL after one month becoming a predictor myopia control. Method This study retrospectively included 106 children aged 8 14 wearing OK lenses. eyes (AL) at first-month visit were enrolled shortening (ALS) group, 52 without no (NALS) group. Axial refractive error baseline within (20 months), including fitting, washout re-wear,...