Osteosarcoma is the most common primary malignant bone tumor affecting children and adolescents. The majority of patients are treated by surgery chemotherapy but have limited alternative therapeutic options. Kinases play an important role in growth survival cells. We aim to identify specific kinases be vital osteosarcoma cells thus may a key target creating novel anticancer therapies. A lentiviral short hairpin RNA kinase library, screened cells, identified minibrain-related (Mirk) (Dyrk1B)...

Abstract Phosphate rock has great potential value in the application of cut-off walls for heavy metal contaminated sites. The effects initial concentration Pb2+, contact time, temperature and pH on adsorption performance phosphate modified soil-bentonite (PSB) were analyzed by Batch tests, microstructure physicochemical properties adsorbent characterized scanning electron microscopy (SEM), X-ray diffraction (XRD) Fourier transform infrared spectroscopy (FT-IR). results showed that...

AIM: After transarterial chemoembolization (TACE), the residual cancer cells are under extensive hypoxic or even anoxic environment. Hypoxia can lead to adaptive responses. For example, angiogenesis will help these survive. In this study, we examined effect of TACE on and expression vascular endothelial growth factor (VEGF) basic fibroblast (b-FGF) assess their relevance Walker-256 transplanted hepatoma. METHODS: Male Wistar rats were inoculated with tumor in left lobe liver. Angiography...

In this work, we propose an efficient and accurate full-chip through-silicon-via (TSV) interfacial crack analysis flow design optimization methodology to alleviate TSV problems in 3D ICs. First, analyze at TSV/dielectric liner interface caused by TSV-induced thermo-mechanical stress. Then, explore the impact of placement conjunction with various associated structures such as landing pad dielectric on crack. Next, present a based experiments (DOE) response surface method (RSM). Finally,...

In this work, we propose an efficient and accurate full-chip through-silicon-via (TSV) interfacial crack analysis flow design optimization methodology to alleviate TSV problems in 3D ICs. First, analyze at TSV/dielectric liner interface caused by TSV-induced thermo-mechanical stress. Then, explore the impact of placement conjunction with various associated structures such as landing pad dielectric on crack. Next, present a based experiments (DOE) response surface method (RSM). Finally,...

This study proposes a genetic algorithm to solve the biobjective vehicle routing problem with time windows simultaneously considering total distance and balance of active fleet. A new complex chromosome is used present route. Through tournament selection, one-point crossover, migrating mutation operator, solution solved. In experiment on Solomon's benchmark problems, balance, results are improved in all classes problems. According experimental results, suggested approach sufficient average...

Riverine sediment transport plays an important role in the global geochemical cycle. With a growing interest riverine environmental changes, better understanding of water-sediment relationship dynamics and their driving forces is crucial for basin management, which particularly associated with cascade dam construction. In this contribution, simple effective load reduction factor analysis used to attribute changes river different drivers. The Mann–Kendall (MK) trend test double-mass curve...

Following the implementation of Three Gorges Dam Project, water quality deterioration due to an excess nitrogen (N) and phosphorus (P) from agricultural nonpoint source (ANPS) is major concern in Reservoir Area (TGRA), People's Republic China. An export coefficient model (ECM) was developed provide reasonable estimates on influence ANPS N P loads TGRA based field investigation datasets 1996 2013. Additionally, potential total (TN) (TP) originating a variety sources were estimated analyzed....

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In this study, seven Engineering Geopolymer Composite (EGC) groups with varying proportions were prepared. Rheological, compressive, flexural, and axial tensile tests of the EGC conducted to study effects water/binder ratio, cement/sand fiber type on its properties. Additionally, a uniaxial tension constitutive model was established. The results indicate that exhibits early strength characteristics, 7-day compressive reaching 80% 92% 28-day strength. demonstrates high ductility, achieving up...

In order to study the mechanical properties and stress–strain relationship of geopolymer lightweight aggregate concrete (GLAC), 13 groups different mix proportions were designed. The influence binder ratio, alkali–binder alkali activator modulus, steel fiber volume content, coarse water–binder ratio on cube compressive strength, splitting tensile flexural strength axial compression performance GLAC was analyzed. failure process characteristics under analyzed, curve obtained, calculation...

The determination of liquid limit is great significance in the engineering classification soil and selection control standard highway subgrade packing compactness. Based on research achievements many scholars relationship between shear strength depth cone penetration fall tests tests, process was analyzed according to Law Conservation Energy, expression K derived. Then, verified by experimental data different existing various countries institutions. And, results were also compared with those...

t is a developing trend for the filter aids industry that producing using diatomite concentrate of beneficiation owing to limited resources high quality diatomite. In present paper characteristics from LinJiang were studied systematically. Additionally, blending processes with flux, disintegration methods after calcination, effect distribution size and soaking time on permeability are explored. It expected be significative industries preparation filtration applications.

The thermal efficacy of interface material (TIM) is highly dependent on its ability to adhere the surfaces interest. Any delamination TIM from die or lid will increase local resistance and, thus, reduce overall effectiveness TIM. Although significant amount work has been done understanding and moisture effects various polymer materials used in microelectronic package assemblies, very limited study effect temperature delamination. In this paper, a sequential hygro-thermal-mechanical...

Abstract The Integrated Biosphere Simulator (IBIS) has mainly been applied to simulate carbon and water cycles at large spatio-temporal scales, but not localized, validated, in Chinese forests. In this study, we first localized the IBIS forest regions Northeastern China, simulated net primary production (NPP) soil respiration (R S) stand validated simulations with measurements from seven six representative types region, respectively. Secondly, explored spatial patterns of NPP R S model...

As the 2 m thick compacted clay liner with permeability coefficient of 1 × 10 −7 cm/s is required in Chinese technical specifications about landfill, performance this was analyzed considering three different adsorption isotherms (convex, straight, and concave). The effects source concentration, mode, waterhead on breakthrough curve time Pb 2+ were discussed. results indicate that reducing concentration pollution sources beneficial to prolonging time. With m, absolute time, respectively,...