A5019832472- Vector-borne infectious diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Toxin Mechanisms and Immunotoxins
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Legionella and Acanthamoeba research
- Calpain Protease Function and Regulation
- Biochemical and Molecular Research
Washington State University
2022-2024
Abstract STING (STimulator of Interferon Genes) is a cytosolic sensor for cyclic dinucleotides (CDNs) and initiates an innate immune response upon binding to CDNs. Coxiella burnetii Gram-negative obligate intracellular bacterium the causative agent zoonotic disease Q fever. The ability C. inhibit host cell death critical factor in development. Previous studies have shown that inhibits apoptosis at early stages infection. However, during late-stages infection, there lysis resulting release...
Abstract Coxiella burnetii is an obligate intracellular bacteria which causes the global zoonotic disease Q Fever. Treatment options for infection are limited, and development of novel therapeutic strategies requires a greater understanding how C. interacts with immune signaling. Cell death responses known to be manipulated by , but role caspase-8, central regulator multiple cell pathways, has not been investigated. In this research, we studied bacterial manipulation caspase-8 signaling...
Abstract Apolipoprotein B messenger RNA (mRNA) editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases cause genetic instability during cancer development. Elevated APOBEC3A (A3A) levels result in APOBEC signature mutations; however, mechanisms regulating A3A abundance breast are unknown. Here, we show that dysregulating the ubiquitin-proteasome system with proteasome inhibitors, including Food and Drug Administration-approved anticancer drugs, increased multiple myeloma cell...
Abstract Coxiella burnetii is a Gram‐negative, obligate intracellular, macrophage‐tropic bacterium, and the causative agent of zoonotic disease Q fever. The epidemiology fever associated with presence infected animals; sheep, goats, cattle, humans primarily become by inhalation contaminated aerosols. In humans, acute phase characterized influenza‐like symptoms, approximately 3%–5% individuals develop chronic infection. C. infection activates many types immune responses, bacteria’s genome...
ABSTRACT The Gram-negative bacterium Coxiella burnetii is the causative agent of query fever in humans and coxiellosis livestock. C. infects a variety cell types, tissues, animal species including mammals arthropods, but there much left to be understood about molecular mechanisms at play during infection distinct species. Human stimulator interferon genes (STING) induces an innate immune response through induction type I interferons (IFNs), IFN promotes or suppresses replication, depending...
ABSTRACT Coxiella burnetii is an obligate intracellular bacteria that causes the global zoonotic disease Q Fever. Treatment options for chronic infection are limited, and development of novel therapeutic strategies requires a greater understanding how C. interacts with immune signaling. Cell death responses known to be manipulated by , but role caspase-8, central regulator multiple cell pathways, has not been investigated. In this research, we studied bacterial manipulation caspase-8...