A5027754783- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Chronic Kidney Disease and Diabetes
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Aldose Reductase and Taurine
- Bladder and Urothelial Cancer Treatments
- Gout, Hyperuricemia, Uric Acid
- Renal Diseases and Glomerulopathies
- Metabolism, Diabetes, and Cancer
- Dialysis and Renal Disease Management
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Paraquat toxicity studies and treatments
- Metabolism and Genetic Disorders
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Lipid metabolism and disorders
Second Affiliated Hospital of Jilin University
2017-2024
Yunnan Investment Group (China)
2024
Kitasato University
2020-2022
Zhejiang University
2015-2022
Shanghai Clinical Research Center
2022
Chinese PLA General Hospital
2019-2022
Hangzhou Center for Disease Control and Prevention
2022
Shonan Kamakura General Hospital
2020
Chiba Hokusou Hospital
2020
Tokyo Medical University Hospital
2020
Abstract Epidemiological studies have shown that an elevated uric acid (UA) level predicts the development of metabolic syndrome and diabetes; however, there is no direct evidence this underlying mechanism remains unclear. Here, we showed a high-UA diet triggered expression pro-inflammatory cytokines, activated NF-κB pathway increased gliosis in hypothalamus. Intracerebroventricular injection UA induced hypothalamic inflammation reactive gliosis, whereas these effects were markedly...
Background/Aims: Diabetic kidney disease (DKD) is a leading cause of end-stage renal (ESRD) worldwide, and the importance tubular injury has been highlighted in recent years.However, underlying mechanisms effective therapeutic targets are still unclear.In this study, we investigated mtDNA, mitochondrial dynamics, function metabolic pathways to determine if damage plays critical role development DKD patients.Methods: A cross-sectional study was carried out among healthy controls (HCs, n =...
Abstract Acne vulgaris represents a chronic inflammatory condition, the pathogenesis of which is closely associated with altered skin microbiome. Recent studies have implicated profound role Gram‐negative bacteria in acne development, but there lack antiacne agents targeting these bacteria. Polyphyllins are major components Rhizoma Paridis great anti‐inflammatory potential. In this study, we aimed to evaluate effects and underlying mechanisms PPH PPH‐enriched extract (RPE) treating...
The mechanisms of hepatitis B virus (HBV) persistent infection are not completely understood. Interleukin (IL)-35, which is a newly identified cytokine belongs to IL-12 family, has been demonstrated induce immunotolerance. Thus, the aim current study was investigate role IL-35 during chronic HBV infection. A total 61 patients with [37 (CHB) and 24 asymptomatic carriers (ASC)] 20 healthy individuals were enrolled. concentration as well modulatory function on CD4+CD25+CD127dim/- regulatory T...
Interleukin (IL)-35 is a newly identified IL-12 cytokine family member, which has been demonstrated to induce immunotolerance by suppression of CD8+ T cells function in chronic viral hepatitis. However, the role IL-35 modulating activity nonviral hepatitis-related hepatocellular carcinoma (HCC) was not fully elucidated. Forty-four patients with HCC and twenty healthy individuals were enrolled. Serum concentration measured ELISA. purified from peripheral bloods liver tissues. mRNA expression...
Interleukin (IL)-35 regulates imbalance between regulatory T cells (Tregs) and helper (Th) 17 cells, leading to an important modulator in autoimmune disorder, cancer, infectious diseases. Our previous study revealed immunosuppressive activity of IL-35 chronic hepatitis B virus (HBV) infection. Thus, the aim current was investigate role function viral specific Tregs/Th17 balance HBV A total 44 HLA-A2 restricted infected patients, including 21 (CHB) 23 asymptomatic carriers (ASC) were...
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies, and its global morbidity mortality are increasing. Previous studies confirmed that miR-342 was involved in development progression malignant tumors. However, relationship between Wnt/β- catenin signaling pathway HCC remains unknown. MATERIALS AND METHODS: Cell viability detected by MTT assay. Immunofluorescence staining used to detect Brdu-positive cells Western blot apoptotic proteins. Furthermore, linear...
Background Diabetic kidney disease (DKD) is the primary cause of end-stage renal disease, raising a considerable burden worldwide. Recognizing novel biomarkers by metabolomics can shed light on new biochemical insight to benefit DKD diagnostics and therapeutics. We hypothesized that serum metabolites serve as in progression DKD. Methods A cross-sectional study 1,043 plasma untargeted LC/MS among 89 participants identified associations between proteinuria severity difference. Pathway analysis...
Abstract Podocyte injury plays a vital role in proteinuria and nephrotic syndrome. Calcineurin (CaN) inhibitors are effective reducing proteinuria. However, their molecular mechanism is still not fully understood. Angiopoietin‐like‐4 (ANGPTL4) secreted protein that mediates podocyte‐related nephropathy. In this study, we established puromycin aminonucleoside (PAN)‐induced minimal‐change disease (MCD) rat model cultured podocyte model. We found CaN protected against PAN‐induced injury,...
Lenvatinib is an oral, multitargeted, tyrosine kinase inhibitor, which suppress tumor angiogenesis and progression. It was non-inferior to sorafenib in overall survival untreated advanced hepatocellular carcinoma (HCC). Sorafenib had a beneficial effect on portocollateral circulation with portal hypertension translating clinical studies. However, the hemodynamic effects of lenvatinib appear be different from those because efficacy for vascular endothelial growth factor receptors fibroblast...
Sorafenib, an active multi-kinase inhibitor, has been widely used as a chemotherapy drug to treat advanced clear-cell renal cell carcinoma patients. In spite of the relative safety, sorafenib shown exert negative impact on cognitive functioning in cancer patients, specifically learning and memory; however, underlying mechanism remains unclear. this study, NMR-based metabolomics approach was applied investigate neurochemical effects rats. Male rats were once daily administrated with 120 mg/kg...
Effective therapy for hepatocellular carcinoma (HCC) is currently an imperative issue, and sorafenib a first-line drug the treatment of HCC. However, clinical benefit often impaired by resistance. Accordingly, present study was conducted to investigate molecular mechanisms involving resistance, with focus on large tumor suppressor 2 (LATS2) mitophagy.HepG2 liver cancer cells were treated infected adenovirus-loaded LATS2 (Ad-LATS2). Cell death, proliferation migration measured via western...
Autotaxin (ATX) has been reported as a direct biomarker for estimating the evaluation of liver fibrosis. But available data on ATX useful complications cirrhosis (LC) are scant.To assess clinical usefulness assessing LC.This multicenter, retrospective study was conducted at six locations in Japan. We include patients with LC, n = 400. The level evaluated separately men and women because its high female patients. To area under curve (AUC) severe analyzed comparison model end-stage disease...
Abstract Background Hyperphosphatemia, hypocalcemia, and elevation of parathyroid hormone (PTH) are typical abnormalities uremic patients with Secondary hyperparathyroidism (SHPT). However, metabolic imbalance associated SHPT is not well understood. Methods A total 15 an intact (iPTH) level > 600 pg/mL were set as preoperative (PR) group, age‐ gender‐matched controls who had undergone parathyroidectomy plus forearm transplantation because achieved iPTH <150 postoperative (PO) group....
Objective . To research the clinical characteristics and risk factors of lung cancer-associated acute ischemic stroke (LCA-AIS). Methods Patients diagnosed with LCA-AIS, simple cancer, AIS were enrolled. The primary information, laboratory results, tumor histopathology, neurological deficits, survival time patients collected analyzed. Results (1) In LCA-AIS group, pathology 69.56% adenocarcinoma, proportion poorly differentiated was significantly more than that in moderately or highly...