Visfatin (also known as pre-B cell colony-enhancing factor or PBEF) is a cytokine that highly expressed in visceral fat and whose blood levels correlate with obesity. Originally isolated secreted promotes the growth of B precursors recently found to act an insulin analog on receptor, its pathophysiological role humans remains largely unknown.In this study we investigated whether plasma visfatin level altered patients type 2 diabetes mellitus (T2DM).Plasma well adiponectin resistin...

Epicardial adipose tissue (EAT) is a part of visceral fat deposited around the heart between pericardium and myocardium along distribution coronary arteries. EAT thickness reported to be associated with atherosclerosis; however, no study has measured volume in patients type 2 diabetes or investigate its association artery disease.A hospital-based case control study.A total 49 mellitus (T2DM) 78 nondiabetic controls were studied.Cardiac multislice computed tomography was used measure volume,...

Adiponectin, an adipocyte-derived peptide with antiinflammatory and antiatherogenic effects, is known to protect against the initiation progression of atherosclerosis. In this study, we investigate whether hypoadiponectinemia present in patients ischemic cerebrovascular disease (CVD).In case-control plasma adiponectin concentration was measured by enzyme-linked immunosorbent assay type 2 diabetic nondiabetic subjects or without CVD. A total 534 were studied. The mean level 228 CVD...

Patients with a history of cardiovascular disease are at high risk developing secondary major adverse cardiac events (MACE). This study aimed to identify independent predictors MACE after hospital admission which could be used high-risk patients who may benefit from preventive strategies. included 1,520 consecutive coronary artery (CAD) (654 acute syndrome (ACS) and 866 elective percutaneous intervention (PCI) patients) received PCI and/or stenting. was defined as all-cause mortality or...

Abstract Background The purpose of this study was to investigate whether the pretreatment total and differential leukocyte counts can predict prognosis patients with oral cavity cancer. Methods In a retrospective analysis treated between 2004 2011, medical records 202 cancer were evaluated. Results Patients cancer, peripheral white blood cell (WBC) count, monocyte, neutrophil lymphocyte ratio increased advancement clinical stage. contrast, count decreased. Further, WBC, in those pathologic...

Background: Diabetes mellitus is the leading cause of diabetic nephropathy and a major public health issue worldwide.Approximately 20-30% patients with type 2 diabetes (T2DM) have renal impairment.Fatty acid-binding protein 1 (FABP1) expressed in proximal tubule cells released into urine response to hypoxia caused by decreased peritubular capillary blood flow, FABP2 responsible for transport free fatty acids intestinal endothelium cells.There increasing evidence that FABP1 FABP play role...

OBJECTIVE—Because of increasing evidence that white blood cells (WBCs) play a role in the development and progression diabetes complications, this study aimed to investigate relation circulating total differential leukocyte counts nephropathy patients with type 2 diabetes. Plasma leptin levels were also measured their peripheral leukocytosis. RESEARCH DESIGN AND METHODS—For study, 1,480 subjects who enrolled disease management program stratified according urinary microalbumin serum...

Abstract Background There is increasing evidence that leukocytes play a central role in obesity, glucose intolerance, type 2 diabetes mellitus (T2DM), and cardiovascular diseases, but the of differential metabolic syndrome (MetS) atherosclerosis largely unknown. The aim this study was to examine relationship between component features MetS peripheral leukocyte counts explore whether are associated with clustering macrovascular diseases patients T2DM. Methods 1872 subjects T2DM who enrolled...

The Review of Diabetic Studies,2010,7,4,275-284.DOI:10.1900/RDS.2010.7.275Published:February 2011Type:Original ArticleAuthors:Cheng-An Chiu, Li-Fen Lu, Teng-Hung Yu, Wei-Chin Hung, Fu-Mei Chung, I-Ting Tsai, Chih-Ying Yang, Chia-Chang Hsu, Yung-Chuan Chao-Ping Wang, and Yau-Jiunn Lee Author(s) affiliations:Cheng-An Chiu1, Lu2, Yu1, Hung1, Chung1, Tsai3, Yang3, Hsu4, Lu5, Wang1,6, Lee7 1Division Cardiology, 2Division Cardiac Surgery, Department 3Department Emergency, 4Division...

Secreted frizzled-related protein 5 (Sfrp5), an endogenous inhibitor of wingless-type MMTV integration site family (Wnt) signalling, is anti-inflammatory adipokine whose expression perturbed in models obesity and type 2 diabetes mellitus (T2DM). Wnt member 5a (Wnt5a) a representative ligand, recent reports suggest that Wnt5a involved inflammatory diseases metabolic disorders. The aim this study was to investigate whether plasma Sfrp5 levels are altered patients with T2DM.Plasma...

Indoxyl sulfate (IS) is linked to endothelial damage, NF-κB activation and induced development of atherosclerosis. The purpose this study was investigate the relationship between serum IS levels severity coronary artery stenosis. In addition, among various cardiovascular risk factors also explored.Serum concentrations were measured using ultra performance liquid chromatography in 191 consecutive patients presenting with stable angina. associations angiographic indexes number diseased...

Background: Fatty acid-binding protein 1 (FABP1) (also known as liver-type fatty or LFABP) is a that mainly expressed in the liver, and associated with hepatocyte injury acute transplant rejection. Reduced levels of FABP1 mice livers have been shown to be effective against nonalcoholic liver disease (NAFLD). In this study, we investigated association between plasma NAFLD patients type 2 diabetes mellitus (T2DM). Methods: We enrolled 267 T2DM patients. Clinical biochemical parameters were...

Background: Cytochrome P450 (CYP) 2J2 is a regulatory enzyme in the biosynthesis of biologically active cis-epoxyeicosatrienoic acids (EETs). EETs have been suggested to modulate PPAR-γ and PPAR-α transcription activity play role stimulus-secretion coupling pancreatic beta cells. Genetic abnormalities expression CYP2J enzymes may pathogenesis type 2 diabetes mellitus (T2DM). Our objective was investigate CYP2J2 G-50T polymorphism (rs890293) association with insulin resistance markers T2DM...

Background: Transcription factor 7-like 2 (TCF7L2) is a key member of the T-cell factor/lymphoid enhancer family, and it plays pivotal role in human physiological processes has been implicated various pathological conditions. TCF7L2 associated with inflammation, metabolic regulation, development atherosclerosis. Notably, exerts an anti-atherosclerotic effect by activating specific molecular pathways. Furthermore, polymorphisms have severity coronary artery disease (CAD) related mortality....

Background. Moderate alcohol consumption is widely recognized as beneficial in the prevention of cardiovascular disease, yet renal effects intake are still controversial. The present study designed to investigate influence on calculated creatinine clearance rate (CCr) and glomerular filtration (GFR) a Southern Taiwan Pai-Wan aboriginal community with high prevalence consumption.

Even though shift work has been suspected to be a risk factor for cardiovascular disease, little research done determine the logical underlying inflammation mechanisms. This study investigated association between and circulating total differential leukocyte counts among Chinese steel workers.The subjects were 1,654 line workers in plant, who responded cross-sectional survey with questionnaire on basic attributes, life style, sleep. All plant received periodic health checkup. Total leukocytes...

<b><i>Background:</i></b> Pruritus is a common and distressing symptom that affects patients with chronic kidney disease (CKD). Indoxyl sulfate (IS) and<i> p</i>-cresylsulfate (PCS) are uremic toxins similar protein binding, dialytic clearance, proinflammatory features. in CKD may correlate better than the glomerular filtration rate (GFR), suggesting either central nervous system or peripherally play an important role pathophysiology....

Objective: Breast cancer is the second most common malignancy globally and a leading cause of death in women. Analysis factors related to disease-free survival (DFS) has improved understanding disease characteristics recurrence. The aim this study was investigate predictors DFS patients with breast enable identification at high risk who may benefit from prevention interventions. Methods: We retrospectively analyzed 559 women underwent treatment between 2004 2022. endpoint DFS. Recurrence...

There is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between and metabolic syndrome (MetS) in male steel workers, also possible mechanism of work-related derangements. A total 1732 men aged 42 ± 8 years were enrolled this cross-sectional study, including 862 day workers 870 workers. Circulating levels resistin measured by ELISA using monoclonal specific antibodies. had higher rates MetS its...

Purpose: Circulating levels of visfatin, a ubiquitous adipokine, may reflect both the severity plaque as well degree stabilization in acute myocardial injury. The purpose this study was to test whether level visfatin is associated with occurrence major adverse cardiovascular events (MACEs) patients ST-elevation infarction (STEMI). Methods: Consecutive (n=185) STEMI were prospectively enrolled study. ELISA used measure plasma concentrations. Composite MACEs included death, recurrent...