A5057212106- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- S100 Proteins and Annexins
- Caveolin-1 and cellular processes
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Cellular transport and secretion
- Radiomics and Machine Learning in Medical Imaging
- Biomedical and Engineering Education
Queen Mary University of London
2023-2025
GlaxoSmithKline (United Kingdom)
2025
University of Southampton
2021-2023
T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for division, differentiation development of effector function. Glucose uptake engagement the glycolytic pathway are major checkpoints this event. Here we show that low-affinity, concentration-dependent glucose transporter 2 (Glut2) regulates CD8
Abstract Oriented cell divisions are critical for the formation and maintenance of structured epithelia. Proper mitotic spindle orientation relies on polarised anchoring force generators to cortex by evolutionarily conserved protein complex formed G αi subunit heterotrimeric proteins, Leucine-Glycine-Asparagine repeat (LGN) nuclear apparatus protein. However, polarity cues that control cortical patterning this ternary remain largely unknown in mammalian Here we identify membrane-associated...
Abstract Patient-derived organoids (PDOs) are in vitro 3D structures that mimic the complexity of tumors, including their molecular and phenotypic features. Recently, numerous studies have demonstrated potential as preclinical model for drug screening tailored treatment selection patients.Non-small cell lung cancer (NSCLC) with its rapid growth early metastasis onset, represents most common cause cancer-related deaths worldwide. Current treatments offer limited long-term survival,...
Abstract Oriented cell divisions are critical for the formation and maintenance of structured epithelia. Proper mitotic spindle orientation relies on polarised anchoring force generators to cortex by evolutionarily conserved G αi -LGN-NuMA complex. However, polarity cues that control cortical patterning this ternary complex remain largely unknown in mammalian Here we identify membrane-associated protein Annexin A1 (ANXA1) as a novel interactor LGN mammary epithelial cells. ANXA1 acts...
Abstract Polarised epithelial cell divisions represent a fundamental mechanism for tissue maintenance and morphogenesis; their dysregulation often leads to developmental disorders cancer. Morphological mechanical changes in the plasma membrane influence organisation crosstalk of microtubules actin at cortex, thereby regulating mitotic spindle machinery chromosome segregation. Yet, precise mechanisms linking remodelling polarity cortical cytoskeleton dynamics ensure accurate execution mitosis...
ABSTRACT Polarised epithelial cell divisions represent a fundamental mechanism for tissue maintenance and morphogenesis. Morphological mechanical changes in the plasma membrane influence organisation crosstalk of microtubules actin at cortex, thereby regulating mitotic spindle machinery chromosome segregation. Yet, precise mechanisms linking remodelling to polarity cortical cytoskeleton dynamics ensure accurate execution mitosis mammalian cells remain poorly understood. Here, we manipulated...