Brenda Nakafeero Simbwa

ORCID: 0000-0003-1221-7197
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About
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Research Areas
  • Viral Infections and Outbreaks Research
  • COVID-19 epidemiological studies
  • Viral Infections and Vectors
  • Vaccine Coverage and Hesitancy
  • Global Maternal and Child Health
  • Pneumonia and Respiratory Infections
  • Global Security and Public Health
  • HIV/AIDS Research and Interventions
  • Tuberculosis Research and Epidemiology
  • Mosquito-borne diseases and control
  • Antibiotic Resistance in Bacteria
  • Resilience and Mental Health
  • Migration, Health and Trauma
  • HIV/AIDS Impact and Responses
  • Disaster Response and Management
  • Malaria Research and Control
  • COVID-19 Digital Contact Tracing
  • Zoonotic diseases and public health
  • Antibiotic Use and Resistance
  • Posttraumatic Stress Disorder Research
  • COVID-19 and Mental Health
  • HIV-related health complications and treatments
  • Bacillus and Francisella bacterial research
  • Diverse Scientific Research Studies
  • Disaster Management and Resilience

Ministry of Health
2024-2025

Makerere University
2021-2024

Infectious Diseases Institute
2024

Epicentre (South Africa)
2024

University of Liverpool
2024

The coronavirus disease 2019 (COVID-19) pandemic significantly impacted health systems worldwide. This study explored the effects of COVID-19 cascade on programmes in Uganda. conducted in-depth interviews with key informants involved Uganda's national response. A cross-sectional exploratory using qualitative approaches was carried out. purposive sample 30 from Ministry Health (MoH) and implementing partners were interviewed (May 2023 - June 2023). Interviews audio recorded analysed inductive...

10.4102/jphia.v16i1.697 article EN cc-by Journal of Public Health in Africa 2025-03-05

BackgroundEarly isolation and care for Ebola Disease patients at Treatment Units (ETU) curb outbreak spread. We evaluated time to ETU entry associated factors during the 2022 Sudan virus disease (SVD) in Uganda.MethodsWe included persons with RT-PCR-confirmed SVD onset September 20–November 30, 2022. categorized days from symptom ('delays') as short (≤2), moderate (3-5), long (≥6); latter two were 'delayed isolation'. timing 'earlier' or 'later,' using October 15 a cut-off. assessed...

10.1016/j.ijid.2024.107073 article EN cc-by-nc-nd International Journal of Infectious Diseases 2024-04-25

BackgroundContact tracing (CT) is critical for ebolavirus outbreak response. Ideally, all new cases after the index case should be previously-known contacts (PKC) before their onset, and spend minimal time ill in community. We assessed impact of CT during 2022 Sudan Virus Disease (SVD) Uganda.MethodsWe collated anonymized data from SVD database to obtain analyse on performance indicators, comparing confirmed that were PKC not (NPKC) onset. effect being number people infected using Poisson...

10.1016/j.ijid.2024.02.002 article EN cc-by-nc-nd International Journal of Infectious Diseases 2024-02-08

Abstract Background: In 2022, a Sudan virus disease (SVD) outbreak occurred in Uganda, resulting 142 confirmed cases, most Mubende and Kassanda districts. We determined risk factors for (SUDV) infection among household members (HHM) of cases. Methods: conducted case-control retrospective cohort study January 2023. Cases were RT-PCR-confirmed SUDV residents or districts during the outbreak. Case-households housed symptomatic, primary case-patient ≥24 hours had ≥1 secondary with onset <2...

10.21203/rs.3.rs-3982950/v1 preprint EN cc-by Research Square (Research Square) 2024-03-26

Abstract Background On 20 September 2022, Uganda declared its fifth Sudan virus disease (SVD) outbreak, culminating in 142 confirmed and 22 probable cases. The reproductive rate (R) of this outbreak was 1.25. We described persons who were exposed to the virus, became infected, they led infection an unusually high number cases during outbreak. Methods In descriptive cross-sectional study, we defined a super-spreader person (SSP) as any with real-time polymerase chain reaction (RT-PCR) SVD...

10.1186/s12879-024-09391-0 article EN cc-by BMC Infectious Diseases 2024-05-23

Abstract Background In 2022, an Ebola disease outbreak caused by Sudan virus (SUDV) occurred in Uganda, primarily affecting Mubende and Kassanda districts. We determined risk factors for SUDV infection among household members (HHM) of cases. Methods conducted a case-control retrospective cohort study January 2023. Cases were RT-PCR-confirmed residents or districts during the outbreak. Case-households housed symptomatic, primary case-patient ≥ 24 h had 1 secondary with onset < 2 weeks...

10.1186/s12879-024-09439-1 article EN cc-by BMC Infectious Diseases 2024-05-30

Abstract Background Communities affected by Ebola disease (EBOD) may face resulting increases in mental health disorders. We evaluated the prevalence of and factors associated with disorders among persons 2022 Sudan virus (SVD) outbreak Uganda. Methods conducted a cross-sectional study SVD survivors family members fatal cases from 15–31 January 2023. included only laboratory-confirmed who lived or cared for confirmed patients during their illness. The Hospital Anxiety Depression Scale was...

10.1007/s44202-024-00203-9 article EN cc-by Discover Psychology 2024-07-22

Early detection of outbreaks requires robust surveillance and reporting at both community health facility levels. Uganda implements Integrated Disease Surveillance Response (IDSR) for priority diseases uses the national District Health Information System (DHIS2) reporting. However, investigations after first case in 2022 Sudan virus outbreak was confirmed on September 20, revealed many deaths among persons with Ebola-like symptoms as far back August. Most had sought care private facilities....

10.1186/s12879-024-09659-5 article EN cc-by-nc-nd BMC Infectious Diseases 2024-07-30

Ebola disease survivors often experience stigma in multiple forms, including felt (perceived) stigma, enacted (action-based) and institutional stigma. On September 20, 2022, Uganda declared a Sudan Virus Disease (species orthoebolavirus sudanense ) outbreak after patient with confirmed virus (SUDV) infection was identified Mubende District. The led to 142 22 probable cases over the next two months. We examined types of experienced by their household members its effect on well-being....

10.1371/journal.pgph.0003272 article EN public-domain PLOS Global Public Health 2024-12-16

Abstract Background Emergence of drug resistant tuberculosis (DR-TB) has aggravated the (TB) public health burden worldwide and especially in low income settings. We present findings from a predominantly nomadic population Karamoja, Uganda with high-TB (3500 new cases annually) sought to determine prevalence, patterns, factors associated DR-TB. Methods used mixed methods data collection. enrolled 6890 participants who were treated for programmatic setting between January 2015 April 2018. A...

10.1186/s12879-021-06675-7 article EN cc-by BMC Infectious Diseases 2021-09-14

<title>Abstract</title> <italic><bold>Background:</bold></italic> In February 2022, a high number of deaths among children was reported to the Ministry Health from Namutumba District. The cause later confirmed as severe malaria. We investigated scope malaria deaths, identified associated factors, and recommended evidence-based control measures inform malaria-prevention programming in <italic><bold>Methods: </bold></italic>We conducted an unmatched case-control study March 2022 most affected...

10.21203/rs.3.rs-3158673/v1 preprint EN cc-by Research Square (Research Square) 2023-07-14

Due to conflict in the Democratic Republic of Congo (DRC), approximately 34,000 persons arrived at Nyakabande Transit Centre (NTC) between March and June 2022. On 12, 2022, Kisoro District reported &gt;330 cases COVID-19 among NTC residents. We investigated outbreak assess its magnitude, identify risk factors, recommend control measures. defined a confirmed case as positive SARS-CoV-2 antigen test an resident during 1–June 30, generated line list through medical record reviews interviews...

10.1371/journal.pgph.0002428 article EN cc-by PLOS Global Public Health 2024-03-06

Abstract Background In July 2022, the Uganda Ministry of Health (MoH) trained Village Team (VHT) members in Kabarole District and rolled out Event-based surveillance (EBS) system with an emphasis on submitting public health signals. We assessed level reporting factors affecting EBS by VHTs District, southwestern Uganda, 2022 ̶ March 2023. Methods conducted a cross-sectional study among key informants (KI) involved activities from district office facilities eight months after rollout...

10.21203/rs.3.rs-3983926/v1 preprint EN cc-by Research Square (Research Square) 2024-03-13

<title>Abstract</title> Background In 2016, Uganda initiated integration of services for non-communicable diseases, including hypertension and diabetes, into existing HIV care services. However, this intervention has not been fully implemented yet in most clinics. We evaluated the costs associated with scaling up diabetes management selected clinics Mbarara Ibanda districts, Uganda. Methods March 2023, we obtained data on providing ten randomly districts including, healthcare providers’...

10.21203/rs.3.rs-4238459/v1 preprint EN cc-by Research Square (Research Square) 2024-04-17

Abstract Background : Continuous monitoring of antimicrobial resistance (AMR) in Uganda involves testing bacterial isolates from clinical samples at national and regional hospitals. Although the National Microbiology Reference Laboratory (NMRL) analyzes these for official AMR surveillance data, there's limited integration into public health planning. To enhance utilization NMRL data to better inform drug selection strategies combating antibiotic resistance, we evaluated trends spatial...

10.21203/rs.3.rs-4271090/v1 preprint EN cc-by Research Square (Research Square) 2024-04-19

Abstract Background Ebola disease survivors often experience stigma in multiple forms, including felt (perceived) stigma, enacted (action-based) and structural (institutional) stigma. On September 20, 2022, Uganda declared a Sudan Virus Disease (SVD, caused by ebolavirus ) outbreak after patient with confirmed virus (SUDV) infection was identified Mubende District. The led to 142 22 probable cases over the next two months. We examined types of experienced their household members its effect...

10.1101/2024.05.07.24307005 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2024-05-08

<title>Abstract</title> <bold>Background</bold> Mass vaccination campaigns are crucial for public health interventions, especially in the eradication of diseases such as polio. Understanding stakeholders' perceptions and experiences during implementation these is essential improving strategies addressing challenges. This study aimed to document experiences, identify challenges, explore a door-to-door mass campaign novel oral polio vaccine (nOPV2) Uganda. <bold>Methods</bold> A qualitative...

10.21203/rs.3.rs-4601358/v1 preprint EN cc-by Research Square (Research Square) 2024-06-19

On 20 May, 2022, the Uganda Virus Research Institute confirmed first reported anthrax outbreak in Bududa District following reports of sudden cattle deaths and suspected human cases four adjacent villages. The Ministry Health through Public Fellowship Program immediately deployed a multi-disciplinary team led by an Epidemiologist, to determine scope, identify risk factors, recommend control measures. investigation included active case finding using standardized definition, medical records...

10.11604/pamj-oh.2024.14.15.42280 article EN cc-by PAMJ - One Health 2024-01-01

<title>Abstract</title> Background Globally, several vaccines, including COVID-19 have been routinely recommended during pregnancy and lactation. However, data on vaccine acceptability uptake among pregnant lactating women are limited in Sub-Saharan Africa. While is no longer a public health emergency it important to take stock of lessons learnt prepare for future threats those that disproportionately affect pregnant/lactating women. We aimed assess vaccines Uganda. Methods This was...

10.21203/rs.3.rs-4844708/v1 preprint EN cc-by Research Square (Research Square) 2024-09-02

On September 20, 2022, Uganda declared an Sudan Virus Disease (SVD) outbreak in Mubende District. Another eight districts were infected September–November 2022. We examined how Ugandan community beliefs and practices spread Ebola (SUDV) A qualitative study was conducted Mubende, Kassanda, Kyegegwa February 2023. Nine focus group discussions six key informant interviews held. investigated whether contributed to spreading (SUDV). Interviews recorded, translated, transcribed, thematically...

10.1007/s44197-024-00302-9 article EN cc-by-nc-nd Journal of Epidemiology and Global Health 2024-10-09
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