A5007362204- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Sports injuries and prevention
- Neuroscience and Neural Engineering
- Signaling Pathways in Disease
- Viral gastroenteritis research and epidemiology
- Cardiovascular Effects of Exercise
- Virus-based gene therapy research
University Hospital Münster
2005-2020
University of Münster
2008-2019
Georgetown University
2005
KU Leuven
2005
AimsClinical observations in patients with long QT syndrome carrying sodium channel mutations (LQT3) suggest that bradycardia caused by parasympathetic stimulation may provoke torsades de pointes (TdP). β-Adrenoceptor blockers appear less effective LQT3 than other forms of the disease.
To investigate whether altered function of adenosine receptors could contribute to sinus node or atrioventricular (AV) nodal dysfunction in conscious mammals, we studied transgenic (TG) mice with cardiac-specific overexpression the A 1 receptor (A AR). Holter ECG was recorded seven freely moving littermate pairs during normal activity, exercise (5 min swimming), and h after exercise. TG had lower maximal heart rates (HR) than wild-type (WT) (normal activity: 437 ± 18 vs. 522 24 beats/min, P...
Adenosine can be released from the heart and may stimulate four different cardiac adenosine receptors. A receptor subtype that couples to generation of cAMP is A2A-adenosine (A2A-AR). To better understand its role in function, we studied mechanical electrophysiological effects transgenic mice overexpress human A2A-AR cardiomyocytes (A2A-TG). We used isolated preparations left atrium, right perfused hearts with surface ECG recording body recordings living mice. The hypothesized arrhythmogenic...
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels encode neuronal and cardiac pace maker currents. The composition of pacemaker channel complexes in different tissues is poorly understood, the presence additional HCN modulating subunits was speculated. Here we show that vesicle-associated membrane protein-associated protein B (VAPB), previously associated with a familial form amyotrophic lateral sclerosis 8, an essential HCN1 HCN2 modulator. VAPB significantly increases...
Organ-directed gene transfer remains an attractive method for both gaining a better understanding of heart disease and cardiac therapy. However, virally mediated products into cells requires prolonged exposure the myocardium to viral substrate. Pericardial injection vectors has been proposed used with some success achieve myocardial transfection may be suitable approach atrial myocardium. Indeed, such organ-specific would particularly useful reverse phenotypes in young adult genetically...