A5101914929- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Virus-based gene therapy research
- Wnt/β-catenin signaling in development and cancer
- Sphingolipid Metabolism and Signaling
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Caveolin-1 and cellular processes
- Apelin-related biomedical research
- Neurogenesis and neuroplasticity mechanisms
- Genetic factors in colorectal cancer
- Medicinal Plants and Bioactive Compounds
- dental development and anomalies
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
Second Affiliated Hospital of Nanchang University
2023-2024
Nanchang University
2023-2024
Southern Medical University
2021
Shenzhen Maternity and Child Healthcare Hospital
2021
Wuhan Union Hospital
2019
Army Medical University
2017
Daping Hospital
2017
First Affiliated Hospital of Dalian Medical University
2015
Dalian Medical University
2015
Huazhong University of Science and Technology
2010-2012
Abstract Background Long noncoding RNAs (lncRNAs) are significant contributors to various human malignancies. The aberrant expression of lncRNA LINC00894 has been reported in We aimed illustrate the role and its underlying mechanism development papillary thyroid carcinoma (PTC). Methods performed bioinformatics analysis differentially expressed from TCGA GEO datasets selected target LINC00894. SRAMP revealed abundant M6A modification sites Further StarBase, GEPIA, was identify related genes...
Abstract Considerable evidence has shown that the Wnt/β-catenin pathway is involved in osteogenic differentiation various stem cells. However, role of regulating rat ectomesenchymal cells (EMSCs), which are considered to be progenitors dental mesenchymal cells, remains unknown. In this study, we demonstrated nuclear β-catenin was upregulated during EMSC differentiation. The Wnt signalling inhibitor IWR-1-endo inhibited differentiation, while agonist SKL2001 promoted it. Moreover, further by...
Abstract The present study attempts to identify the prognostic value and potential mechanism of action colorectal adenocarcinoma hypermethylated (CAHM) in thyroid carcinoma (THCA) by using RNA sequencing (RNA-seq) dataset from Cancer Genome Atlas (TCGA). functional CAHM was explored RNA-seq multiple enrichment analysis approaches. Connectivity map (CMap) online tool also used predict targeted drugs. Survival suggests that THCA patients with high expression have lower risk death than low...
Abstract Background： Long non-coding RNAs (lncRNAs) are significant contributors to various human malignancies. The aberrant expression of lncRNA LINC00894 has been referred in Consequently, our aim is illustrate the role and its underlying mechanism development papillary thyroid carcinoma (PTC). Method： Bioinformatics analysis differentially expressed RNA from TCGA GEO datasets selected target LINC00894.The SRAMP found that there abundant M6A methylation sites LINC00894. And further...
Objective To investigate effect of the recombinant adenovirus Ad-NICD on apoptosis pancreatic acinar cells in vitro.Methods The was propagated 293 and titer determined by plaque bacteriophage formation test.The adenoviruses were infected into AR4-2J,and expression NICD detected using real-time polymerase chain reaction (PCR).Control group,Ad-CMV-transfected group Ad-NICD-transfected set up.Apoptosis induced cerulein Annexin V/PI double labelling cytometry.Results 2.2 × 1010 pfu/L increased...
Objective To explore the effects of retinoblastoma protein-interacting zing-finger gene ( RIZ1) expression defect on proliferation and apoptosis human colonic carcinoma cell lines. Methods Methylation-specific PCR MSP) was used to examine methylation RIZ1 promoter region expressed line LoVo unexpressed SW480.3 × 105 cells every culture flask were demethylated by 5-aza-2'-deoxycytidine (5-aza-CdR) (5 μmol/L) for 48 h, then mRNA protein detected semi-quantitative reverse...
Objective Confirm the expression of regulator G protein signaling-G alpha interacting COOH 2 (GIPC2) in gastric carcinoma cell lines and patient samples compared to that normal controls detect role GIPC2 development. Methods shGIPC2 plasmid are transfected into AGS BCG803 line, respectively. Transfected cells used for proliferation invasion assay as well testing sensitivity chemotherapeutic agents. Results GIPC2 was highly expressed cancer patients (relative tissue vs. control:...