A5077116113- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Hedgehog Signaling Pathway Studies
- Obstructive Sleep Apnea Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sulfur Compounds in Biology
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Pancreatic function and diabetes
- Neural dynamics and brain function
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Bipolar Disorder and Treatment
- Medicinal Plants and Bioactive Compounds
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Treatment of Major Depression
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Alzheimer's disease research and treatments
Case Western Reserve University
2018-2024
Neurological Surgery
2018-2024
University of Cincinnati
2020-2022
University of Cincinnati Medical Center
2022
Universidade de São Paulo
2018-2019
Two recently developed novel rodent models have been reported to ablate microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR + Dtx) or through pharmacologically the CSF1R receptor with its inhibitor (PLX5622). Both widely used in recent years define essential functions of and led high impact studies that moved field forward.Using Cx3cr1-iDTR mice combination Dtx via PLX5622 diet we compared two MRI histology study general anatomy brain CSF/ventricular systems....
A model was previously proposed that DA neurons provide SHH ligand to striatal interneurons, which in turn support the survival of through release trophic factors such as Glial cell-derived neurotrophic factor (GDNF). However, some key clinical observations do not this model, and a recent independent study shows cholinergic neuron does rely on intact projections. To resolve discrepancy, we generated several mouse lines examine exact role neuron-derived
Whereas some patients have important changes in body core temperature (Tb) during systemic inflammation, others maintain a normal Tb, which is intrinsically associated to immune paralysis. One classical model study paralysis the use of repeated administration lipopolysaccharide (LPS), so-called endotoxin tolerance. However, neuroimmune mechanisms tolerance remain poorly understood. Hydrogen sulphide (H2 S) gaseous neuromodulator produced brain by enzyme cystathionine β-synthase (CBS). The...
Objective: Although cerebral ischemia can activate endogenous reparative processes, such as proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) and subgranular (SGZ), majority these new die shortly after injury do not appropriately differentiate into neurons, or migrate functionally integrate brain. The purpose this study was to examine a novel strategy for treatment stroke by optimizing survival ischemia-induced NSCs SVZ SGZ. Methods: Adult SGZ were grown neurospheres...
Objective: Animal models of chronic pain have demonstrated that glial cells are promising target for development analgesic drugs. However, preclinical studies on response under conditions vary depending the cellular markers, species used, experimental design and model. Therefore, we investigate expression profile GFAP Iba-1 during behavioral manifestation sensory disorder in inflammatory neuropathic models. Methods: fibrillary acidic protein (GFAP) ionized calcium binding adaptor molecule-1...
Background and Purpose: Due to the limitation in treatment window of rtPA (recombinant tissue plasminogen activator), development delayed for stroke is needed. Utilizing a specific p53 inhibitor (PFT-a), our group has previously reported enhanced proliferation survival endogenous progenitor cells in-vivo, leading functional recovery animals days weeks after onset. Recently, role amyloid-ß protein precursor (APP) been implicated synapse formation, neural plasticity, differentiation stem...
Sonic Hedgehog (SHH) signaling has a critical role in development of dopaminergic neurons (DA) during early embryonic stages. It been proposed that neuron-derived shh ligand might play essential the homeostasis basal ganglia circuits. A model was previously Dopaminergic provide to striatal interneurons which turn support survival DA through trophic factors such as GDNF. However, some key clinical observations do not this and recent independent study shows cholinergic neuron does rely on...