A5074175018- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Neurological Complications and Syndromes
- Renal and Vascular Pathologies
- Muscle and Compartmental Disorders
- Vascular Procedures and Complications
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Sarcoidosis and Beryllium Toxicity Research
- Heart Failure Treatment and Management
- Vasculitis and related conditions
- Health Systems, Economic Evaluations, Quality of Life
- Vascular anomalies and interventions
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Pharmacological Effects and Toxicity Studies
- Healthcare cost, quality, practices
- Lipoproteins and Cardiovascular Health
- Membrane-based Ion Separation Techniques
- Patient Satisfaction in Healthcare
Auckland District Health Board
2013-2024
University of Auckland
2020-2024
Auckland City Hospital
2013-2022
Royal College of Surgeons in Ireland
2021
Children's Health Ireland at Crumlin
2021
Hull York Medical School
2009-2012
University of Hull
2009-2010
Leeds General Infirmary
2007
Worthing Hospital
2004
Royal Sussex County Hospital
2004
Hemodialysis arteriovenous fistulas (AVFs) are suboptimally used primarily due to problems with maturation, early thrombosis, and patient nonacceptance. An endovascular approach fistula creation without open surgery offers another hemodialysis vascular access option.Prospective, single-arm, multicenter study (Novel Endovascular Access Trial [NEAT]).Consecutive adult non-dialysis-dependent dialysis-dependent patients referred for at 9 centers in Canada, Australia, New Zealand.Using...
Significance Statement Because fluid overload in patients undergoing hemodialysis contributes to cardiovascular morbidity and mortality, there is a global trend use low-sodium dialysate with the goal of reducing overload. To investigate whether lower sodium during improves left ventricular mass, authors conducted randomized clinical trial 99 adults that compared (135 mM) conventional (140 for 12 months. Although participants showed significant improvement status, intervention had no effect...
Abstract Background The current literature recognises that left ventricular hypertrophy makes a key contribution to the high rate of premature cardiovascular mortality in dialysis patients. Determining how we might intervene ameliorate populations has become research priority. Reducing sodium exposure through lower dialysate may be promising intervention this regard. However there is clinical equipoise around because benefit not yet been demonstrated robust prospective trial, and several...
Home-based dialysis therapies, home hemodialysis (HHD) and peritoneal (PD) are underutilized in many countries significant variation the uptake of exists across centers. This study aimed to evaluate patient- center-level characteristics associated with dialysis.The Australia New Zealand Dialysis Transplant (ANZDATA) Registry was used include incident patients from 1997 2017. Uptake defined as any HHD or PD treatment reported ANZDATA within 6 months initiation. Characteristics were evaluated...
In the era of organ shortage, home hemodialysis (HHD) has been identified as possible preferential bridge to kidney transplantation. Data are conflicting regarding comparability HHD and transplantation outcomes. This study aimed compare patient treatment survival between patients transplant recipients.The Australia New Zealand Dialysis Transplant Registry was used include incident on Day 90 after initiation replacement therapy first kidney-only recipients in from 1997 2017. Survival times...
Key Points The inter-rater reliability of reporting hemodialysis catheter-related infectious events between site investigators and trial adjudicators in Australia New Zealand was substantial. high concordance level catheter infections improves confidence using site-level bacteremia rates as a clinical metric for quality benchmarking future pragmatic trials. A rigorous adjudication protocol may not be needed if clearly defined criteria to ascertain catheter-associated are used. Background...
Abstract The use of antibiotic lock solutions as prophylaxis for catheter‐associated blood stream infection (CRBSI) has been shown to be effective in previous randomized controlled trials. However, the cost‐effectiveness this approach had not studied. In 2012, routine gentamicin‐heparin solution used Auckland City Hospital was withdrawn from market, leading a change heparin‐only lock. This then replaced with gentamicin‐citrate 2014. situation allowed review CRBSI rate and financial impact...
Chronic kidney disease is associated with a unique cardiomyopathy, characterized by combination of structural and cellular remodeling, an enhanced susceptibility to ischemia-reperfusion injury. This may represent dysfunction the reperfusion injury salvage kinase pathway due insulin resistance. The uremic heart cardioprotective effects rosiglitazone were investigated. Uremia was induced in Sprague-Dawley rats subtotal nephrectomy. Functional recovery from ischemia investigated vitro control...
After the publication of our paper Dunlop et al. "Rationale and design Sodium Lowering In Dialysate (SoLID) trial: a randomised controlled trial low versus standard dialysate sodium concentration during hemodialysis for regression left ventricular mass", we became aware further data correlating (LV) mass index at baseline their corresponding 12 months, using cardiac magnetic resonance imaging (MRI) in patients on hemodialysis. The original published sample size SoLID 118 was conservative...
The Sodium Lowering in Dialysate (SoLID) trial is an ongoing a multi-center, prospective, randomised, single-blind (assessor), controlled, parallel assignment clinical trial, enrolling 96 home and self-care hemodialysis (HD) patients from 7 centers New Zealand. will evaluate the hypothesis that lower dialysate [Na+] during HD results left ventricular (LV) mass. Since it's inception, observational evidence has suggested increased mortality risk with [Na+], possibly due to exacerbation of...
Acute kidney injury with severe loin pain and patchy renal ischaemia after anaerobic exercise (ALPE) is a rare clinical syndrome. ALPE has predominantly been described in Japanese Korean populations to date. Many cases most recurrent examples are associated hypouricaemia. We describe 28-year-old New Zealand European male without hypouricaemia who developed whilst performing elite-level sport. Avoiding was successful at preventing further episodes. This report confirms the first known case of...
Worldwide, most people requiring kidney replacement therapy receive haemodialysis (HD) three times per week. Greater HD time and/or frequency may improve survival, but implementation requires understanding potential benefits across the range of patients. Using data from Australia and New Zealand Dialysis Transplant Registry, we assessed whether quotidian (defined as >3 sessions/week >5 h/session) was associated with reduced mortality in adult The primary outcome all-cause analysed by a...
Abstract Aim With improved life expectancy over time, the burden of kidney failure resulting in replacement therapy (KRT) older persons is increasing. This study aimed to describe age distribution at dialysis initiation Australia and New Zealand (ANZ) across centres time. Methods Adults initiating as first KRT ANZ from 1999 2018 reported Dialysis Transplant (ANZDATA) Registry were included. The primary outcomes proportion (75 years older) Secondary characterization population compared with...
Abstract Background The health and diversity of the population in New Zealand (NZ) is changing under influence many socio‐economic factors. This may have shifted landscape home haemodialysis (HHD) . Aims To examine demographic clinical changes, determinants HHD training technique outcome mortality between 2008 2015 at Auckland District Health Board, NZ. Methods We compared three incident cohorts patients 2015. Relevant factors, including characteristics, failure, failure were recorded....
The benefits of dialysis in the older population remain highly debated, particularly for certain modalities. This study aimed to explore modality utilization patterns between in-centre haemodialysis (ICHD), peritoneal (PD) and home (HHD) their association with outcomes persons.Older persons (≥75 years) initiating Australia New Zealand from 1999 2018 reported Dialysis Transplant (ANZDATA) registry were included. main aim was characterize describe individual characteristics each pattern....
Previous studies report an association between longer haemodialysis treatment sessions and improved survival. Worldwide, there is a trend to increasing age among prevalent patients receiving haemodialysis. This analysis aimed determine whether the mortality benefit of diminishes with age.This was retrospective cohort study people who first commenced thrice-weekly aged ≥65 years, reported Australia New Zealand Dialysis Transplant (ANZDATA) Registry from 2005 2015, included 90 days after...