Sen Chai

ORCID: 0000-0003-1243-3404
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About
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Research Areas
  • Innovation and Knowledge Management
  • scientometrics and bibliometrics research
  • Private Equity and Venture Capital
  • Business Strategy and Innovation
  • Machine Learning in Materials Science
  • Supply Chain Resilience and Risk Management
  • Innovation Policy and R&D
  • Conferences and Exhibitions Management
  • Innovation, Sustainability, Human-Machine Systems
  • Fibroblast Growth Factor Research
  • Firm Innovation and Growth
  • Sperm and Testicular Function
  • Big Data and Business Intelligence
  • Computational Drug Discovery Methods
  • Proteoglycans and glycosaminoglycans research
  • Big Data Technologies and Applications
  • Connective tissue disorders research
  • Explainable Artificial Intelligence (XAI)
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Complex Systems and Decision Making
  • Reproductive biology and impacts on aquatic species
  • Team Dynamics and Performance
  • Innovative concrete reinforcement materials
  • Recycled Aggregate Concrete Performance
  • Genetic Syndromes and Imprinting

McGill University
2003-2025

Xi'an University of Architecture and Technology
2023

École Supérieure des Sciences Économiques et Commerciales
2015-2022

CY Cergy Paris Université
2017-2021

Harvard University Press
2019

Harvard University
2011-2017

Ocean University of China
2014-2015

McGill University Health Centre
2003

At the heart of scientific discovery are expert researchers who identify research ideas worthy inquiry. While generative artificial intelligence (AI) technologies—large language models, in particular—have been found to outperform humans some tasks, their impact on assisting with generation ideas, one most fundamental tasks science, remains underexplored. We investigate how use AI affects researcher perceptions proposals and attitudes toward integrating into process. In a randomized online...

10.2139/ssrn.5013086 preprint EN 2025-01-01

Mutations that cause constitutive activation of fibroblast growth factor receptor 3 (FGFR3) result in skeletal disorders are characterized by short-limbed dwarfism and premature closure cranial sutures. In previous work, it was shown congenital deficiency FGFR3 led to overgrowth. Using a combination imaging, classic histology molecular cell biology we now show young adult FGFR3−/− mice osteopenic due reduced cortical bone thickness defective trabecular mineralization. The reduction...

10.1093/hmg/ddh034 article EN Human Molecular Genetics 2003-12-08

Abstract Research Summary The flow of knowledge is closely linked to proximity. While extensive works show that long‐term geographic proximity affects work behavior, little known about the effect short‐term colocation, such as conferences. Using participant data at Gordon Conferences, we estimate difference‐in‐differences and instrumental variable models, which attendees who have no prior within‐conference collaborations are more likely collaborate with other attendees, researchers worked...

10.1002/smj.3062 article EN cc-by-nc Strategic Management Journal 2019-07-17

Fibroblast growth factor (FGF) receptor 3 has been identified as a key regulator of endochondral bone development and post-natal metabolism through its action on plate chondrocytes osteoblasts, respectively. It also shown to promote chondrogenesis cartilage production by cultured pre-chondrogenic cells in response FGF18. In the current studies, we show that absence signaling Fgfr3 joints Fgfr3−/− mice leads premature degeneration early arthritis. Degenerative changes matrix included...

10.1093/hmg/ddl100 article EN Human Molecular Genetics 2006-04-19

10.1016/j.respol.2018.11.006 article EN publisher-specific-oa Research Policy 2018-11-27

Members of global teams are often dispersed across time zones. This paper introduces the construct temporal brokerage, which we define as being in a position within team’s structure that bridges subgroups have little or no overlap with each other. Although brokerage is not formal role, argue occupying such makes an individual more likely to take on coordination work than other members team. We suggest that, while engaging has advantages form enhanced integrative complexity, it also comes...

10.1287/orsc.2020.1406 article EN Organization Science 2020-11-06

Why do researchers on the verge of breakthrough sometimes miss discovery? While extensive literatures have modeled course successful discovery and pinpointed factors associated with groundbreaking discoveries, I focus understanding why near misses occur by interviewing scientists who were very close to discovering ribonucleic acid (RNA) interference in biology but ultimately missed out. identify three mechanisms rooted paradigmatic rigidity that led seminal being several times: not noticing...

10.1287/orsc.2017.1134 article EN Organization Science 2017-05-01

We examine how catastrophic innovation failure affects organizational and industry legitimacy in nascent sectors by analyzing the interactions between Virgin Galactic stakeholders space community aftermath of firm’s 2014 test flight crash. Following failure, we find that participants use their interpretations to either uphold or challenge firm while maintaining industry. These dynamics yield two interesting effects. First, show that, upholding industry, different rhetorically redraw...

10.1287/orsc.2021.1467 article EN Organization Science 2021-07-16

With the availability of large datasets and advanced correlation/statistical methods, will we still need to rely on hypotheses in scientific inquiry? Traditionalists argue that purely data-driven one may not know where look for those interesting findings if no were formed beforehand. Big data advocates, other hand, with prior beliefs, is constrained by established ways thinking or doing, opening possibilities breakthrough insights nobody had looked before. To explore these questions, examine...

10.5465/ambpp.2016.14843abstract article EN Academy of Management Proceedings 2016-01-01

Abstract Following widespread availability of computerized databases, much research has correlated bibliometric measures from papers or patents to subsequent success, typically measured as the number publications citations. Building on this large body work, we ask following questions: given available information in one year, along with combined theories sources creative breakthroughs literatures creativity and innovation, how accurately can explain impact authors a community year? In...

10.1093/icc/dtz042 article EN Industrial and Corporate Change 2019-06-25

Temporal dispersion is an important characteristic of global teams, as members such teams are often distributed across multiple time zones. This paper introduces the construct temporal brokerage, which we define being in a position within team’s structure that bridges subgroups who have little or no overlap with each other. Although brokerage not formal role, argue occupying makes individual more likely to take on coordination work than other team. We suggest while engaging has advantages...

10.5465/ambpp.2020.13037abstract article EN Academy of Management Proceedings 2020-07-29

Scientific research and its translation into commercialized technology is a driver of wealth creation economic growth. Partnerships to foster the translational processes from public organizations, such as universities hospitals, private firms are policy tool that has attracted increased interest. Yet questions about efficacy efficiency with which funds used subject frequent debate. This paper examines empirical data Danish National Advanced Technology Foundation (DNATF), an agency...

10.2139/ssrn.2197876 article EN SSRN Electronic Journal 2013-01-01
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