A5049979296- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Synthesis and biological activity
- RNA and protein synthesis mechanisms
- Animal Ecology and Behavior Studies
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- RNA Interference and Gene Delivery
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Synthesis and Characterization of Heterocyclic Compounds
- Glutathione Transferases and Polymorphisms
- Clostridium difficile and Clostridium perfringens research
- Poisoning and overdose treatments
- Pharmacological Effects of Medicinal Plants
- Research on Leishmaniasis Studies
- Nephrotoxicity and Medicinal Plants
- T-cell and Retrovirus Studies
- Trypanosoma species research and implications
- Cervical Cancer and HPV Research
- Quinazolinone synthesis and applications
- Toxin Mechanisms and Immunotoxins
- Drug-Induced Hepatotoxicity and Protection
- PARP inhibition in cancer therapy
- Metal complexes synthesis and properties
Rudjer Boskovic Institute
2020-2025
University of Zagreb
2022
Nucleic acid ADP-ribosylation and its associated enzymes involved in catalysis hydrolysis are widespread among all kingdoms of life. Yet, roles mammalian bacterial physiology including inter-/intraspecies conflicts currently underexplored. Recently, several examples enzymatic systems for RNA have been identified, showing that major types species, messenger RNA, ribosomal transfer can be targeted by ADP-ribosyltransferases (ARTs) which attach ADP-ribose modifications either to nucleobases,...
A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1,2,3-triazole ring with a p-substituted phenyl benzyl moiety, were synthesised and evaluated in vitro against four human tumour cell lines protozoan parasite Trypanosoma brucei. The influence type amidino substituent linker on antiproliferative antitrypanosomal activities was observed, showing that imidazoline moiety had major impact both activities. Benzothiazole 14a, which connected...
Interactions of an array nucleic acid structures with a small series benzothiazole ligands (bis-benzothiazolyl-pyridines—group 1, 2-thienyl/2-benzothienyl-substituted 6-(2-imidazolinyl)benzothiazoles—group 2, and three 2-aryl/heteroaryl-substituted 3) were screened by competition dialysis. Due to the involvement DNA:RNA hybrids triplex helices in many essential functions cells, this study’s main aim is detect benzothiazole-based moieties selective binding or spectroscopic response these...
<h3>Introduction/Background</h3> The goal of study was to examine the effects alpha-lipoic acid (LA) supplementation on oxidative stress markers in patients with low-grade squamous intraepithelial lesion (LSIL). <h3>Methodology</h3> One hundred (100) diagnosed LSIL were randomized receive 600 mg/day LA (treatment group-T) or placebo (control-C) for three months. Ninety (90) finished (40 controls and 50 treated). Venous blood collected analysis (plasma ferric reducing power (FRAP), superoxide...
We showed that aristolochic acid toxin (ARI) and its fluorescent analogue form inclusion complexes with various cyclodextrins (CDs), including the clinically used γ-CD: Sugammadex. The binding affinity of ARI towards CDs varied on a CD size rim modifications, whereby stability ARI/Sugammadex complex was 2-fold greater than to serum albumin (BSA), blood protein well-known as transporter small molecules similar ds-DNA. Molecular modelling supported formation ARI/ Sugammadex carboxyl group...