A5037117119- Pharmacogenetics and Drug Metabolism
- Genomics and Rare Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Migration, Ethnicity, and Economy
- Lipoproteins and Cardiovascular Health
- Race, History, and American Society
- BRCA gene mutations in cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Practices and Patient Outcomes
- Diabetes Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Irish and British Studies
- Statistical Methods in Clinical Trials
- Educator Training and Historical Pedagogy
- Asian American and Pacific Histories
- Theater, Performance, and Music History
- Health and Medical Research Impacts
- Diaspora, migration, transnational identity
- Shakespeare, Adaptation, and Literary Criticism
- Philippine History and Culture
- Ethics in Clinical Research
- Medication Adherence and Compliance
- Fashion and Cultural Textiles
- Cultural Heritage Management and Preservation
Sanford Health
2019-2025
University of South Dakota
2019-2025
Illinois Wesleyan University
1998
University of Notre Dame
1992
Twin Cities Orthopedics
1991
University of Minnesota
1991
Genetic testing has the potential to revolutionize primary care, but few health systems have developed infrastructure support precision population medicine applications or attempted evaluate its impact on patient and provider outcomes. In 2018, Sanford Health, nation’s largest rural nonprofit care system, began offering genetic patients. To date, more than 11,000 patients participated in Chip Program, over 90% of whom been identified with at least one informative pharmacogenomic variant,...
The convergence of translational genomics and biomedical informatics has changed healthcare delivery. Institutional consortia have begun implementing lab testing decision support for drug–gene interactions. Aggregate datasets are now revealing the impact clinical Given pleiotropic nature pharmacogenes, interdisciplinary teams robust tools must exist within an framework built to be flexible capable cross-talk between specialties. Navigation challenges presented with implementation five steps...
Metoprolol is a medication commonly utilized in select patients to achieve reduction heart rate, systolic blood pressure, or other indications. A majority of metoprolol metabolism occurs via CYP2D6. Decreased expression the CYP2D6 enzyme increases concentration metoprolol. Current pharmacogenomics guidelines by Dutch Pharmacogenomics Working Group recommend slower titrations and dose decreases minimize adverse effects from poor metabolizers normal taking concomitant medications that are...
To understand how attitudes toward pharmacogenomic (PGx) testing among healthcare providers varies by specialty.
Genetic variants can impact medication response. The study of genetic on medications is called pharmacogenomics (PGx). Understanding PGx results be difficult as are reported differently than other laboratory tests. Patients have a lack understanding and satisfaction with information. Surveys were emailed to patients seen in the clinic who participated an elective screening (Sanford Chip) at Sanford Health. conducted assess literacy, testing. Survey responses summarized using descriptive...
Abstract Purpose We describe the implementation and ongoing maintenance of CYP2C19 CYP2D6 focused pharmacogenetic (PGx) testing to guide antidepressant antianxiety medication prescriptions in a large rural, nonprofit health system. Summary Depression anxiety are common psychiatric conditions. Sanford Health implemented PGx for metabolism cytochrome P450 (CYP) isozymes 2C19 2D6 2014 inform prescribing multiple medications, including therapies. As guidelines, genotype phenotype translation,...
Background: Statins are commonly used medications. Variants in SLCO1B1, CYP2C9, and ABCG2 known predictors of muscle effects when taking statins. More exploratory genes include RYR1 CACNA1S, which can also be associated with disease conditions. Methods: Patients pathogenic/likely pathogenic variants or CACNA1S were identified through an elective genomic testing program. Through chart review, patients a history statin use assessed for statin-associated symptoms (SAMS) along collection...
Clopidogrel requires
Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual’s genotype in conjunction with other important clinical factors. Despite significant evidence of genetic associations response, pharmacogenetic testing has not been widely implemented into practice. Among the barriers broad implementation are limited guidance for how successfully integrate workflows data The Pharmacogenomics Global Research Network...
Background: Returning pharmacogenomics (PGx) results to patients is complex and challenging. Patients prefer provider education; however, a gap in comfort PGx has been documented. Objectives: This study's purpose was evaluate satisfaction with the return of test using patient portal message. Methods: A survey sent two cohorts results, one that received result message did not. Results: Following implementation message, there decrease reporting negative responses surrounding their 39%...
Background: SLCO1B1 variants are known to be a strong predictor of statin-associated muscle symptoms (SAMS) risk with simvastatin. Methods: The authors conducted retrospective chart review on 20,341 patients who had genotyping quantify the uptake clinical decision support (CDS) for genetic impact SAMS risk. Results: A total 182 417 CDS alerts generated, and 150 these (82.4%) received pharmacotherapy that did not increase risks SAMS. Providers were more likely cancel simvastatin orders in...
Aim: This manuscript describes implementation of clinical decision support for providers concerned with perioperative complications malignant hyperthermia susceptibility. Materials & methods: Clinical susceptibility was implemented in 2018 based around our pre-emptive genotyping platform. We completed a brief descriptive review patients who underwent testing, focused particularly on RYR1 and CACNA1S genes. Results: To date, we have genetic testing more than 10,000 patients; 13 having been...
The Black Mammy and the Irish Bridget:Domestic Service Representation of Race, 1830–1930 April Schultz (bio) In January 1884, Puck magazine featured a full-color, two-panel cartoon entitled “Our Self-Made ‘Cooks’: From Paupers to Potentates.”1 On left simian-featured peasant woman in rags is being forcibly ejected from tumbledown cottage. She further burdened by her elderly mother emaciated child sleeping on an equally pig front meager fire. caption reads, “They are evicted old country.”...
Aim: Long QT syndrome (LQTS) is an inherited condition that predisposes individuals to prolongation of the interval and increased risk for Torsade de Pointes. Pathogenic variants in three genes - KCNH2, KCNQ1 SCN5A are responsible most cases LQTS, recent advances genetic testing have improved knowledge disease, access follow-up, reduced adverse cardiovascular outcomes. Methods: Based around our preemptive screening platform which includes long listed above, we developed implemented a...
Journal Article "The Pride of the Race Had Been Touched": The 1925 Notse-American Immigrarion Centennial and Ethnic Identity Get access April Schultz Ph.D. candidate in American studies University Minnesota, Twin Cities Search for other works by this author on: Oxford Academic Google Scholar History, Volume 77, Issue 4, March 1991, Pages 1265–1295, https://doi.org/10.2307/2078262 Published: 01 1991
Introduction: Pharmacogenomics (PGx) aims to maximize drug benefits while minimizing risk of toxicity. Although PGx has proven beneficial in many settings, clinical uptake lags. Lack clinician confidence and limited availability testing can deter patients from completing testing. A few novel clinic models have been described as a way incorporate into the standard care. Background: was implemented fill an identified gap provider availability, confidence, utilization across our health system....
Journal Article Immigration Reconsidered: History, Sociology, and Politics. Ed. by Virginia Yans-McLaughlin. (New York: Oxford University Press, 1990. Cloth, $39.95; paper, $14.95.) Get access Yans-McLaughlin Virginia. April Schultz of Notre Dame Search for other works this author on: Academic Google Scholar American Volume 78, Issue 4, March 1992, Pages 1408–1409, https://doi.org/10.2307/2079357 Published: 01 1992
Book Review| April 01 2000 Beyond Pluralism: The Conception of Groups and Identities in America America, Wendy F. Katkin, Ned Landsman Andrea Tyree. Schultz Search for other works by this author on: This Site Google Journal American Ethnic History (2000) 19 (3): 107–108. https://doi.org/10.2307/27502583 Cite Icon Share Facebook Twitter LinkedIn MailTo Permissions Citation Schultz; America. 1 January 2000; doi: Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers...
Journal Article Nation and Commemoration: Creating National Identities in the United States Australia. By Lyn Spillman. (New York: Cambridge University Press, 1997. xii, 252 pp. Cloth, $59.95, ISBN 0-521-57404-8. Paper, $18.95, 0-521-57432-3) Get access April Schultz Illinois Wesleyan University, Bloomington, Search for other works by this author on: Oxford Academic Google Scholar of American History, Volume 85, Issue 1, June 1998, Pages 295–296, https://doi.org/10.2307/2568557 Published: 01 1998