A5044439361- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Child Nutrition and Feeding Issues
- Family and Disability Support Research
- Neuroscience and Music Perception
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- Behavioral and Psychological Studies
- EEG and Brain-Computer Interfaces
- Hearing Loss and Rehabilitation
- Educational and Psychological Assessments
- Language Development and Disorders
- Poisoning and overdose treatments
- Advanced Neuroimaging Techniques and Applications
- Eating Disorders and Behaviors
- Metabolism and Genetic Disorders
- Electroconvulsive Therapy Studies
- Cardiovascular Syncope and Autonomic Disorders
- Education and Critical Thinking Development
- Diet and metabolism studies
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Face Recognition and Perception
Children's Hospital of Philadelphia
2016-2025
Imaging Center
2015-2025
Center for Autism and Related Disorders
2012-2025
University of Pennsylvania
2019-2024
Children's National
2012-2021
Simons Foundation
2021
Vassar College
2019
California University of Pennsylvania
2017
University of Rochester
2006-2009
Evidence indicates an overrepresentation of youth with co-occurring autism spectrum disorders (ASD) and gender dysphoria (GD). The clinical assessment treatment adolescents this co-occurrence is often complex, related to the developmental aspects ASD. There are no guidelines for care when ASD GD co-occur; however, there clinicians researchers experienced in co-occurrence. This study develops initial consensus GD, from best practices current experts field. Expert participants were identified...
Autism spectrum disorder (ASD) is hypothesized to arise from imbalances between excitatory and inhibitory neurotransmission (E/I imbalance). Studies have demonstrated E/I imbalance in individuals with ASD also corresponding rodent models. One neural process thought be reliant on balance gamma-band activity (Gamma), support arising observed correlations motor, as well visual, Gamma underlying GABA concentrations healthy adults. Additionally, decreased has been relevant animal models, though...
Abnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary cortex processing, have been reported in children who autism spectrum disorder (ASD). Some studies an association between delays these responses language impairment. However, as most prior research has focused on verbal individuals with ASD without cognitive impairment, rather little is known about neural activity during processing minimally or nonverbal (ASD-MVNV)—children no speech often significant To...
Abstract Age‐related changes in resting‐state (RS) neural rhythms typically developing children (TDC) but not with autism spectrum disorder (ASD) suggest that RS measures may be of clinical use ASD only for certain ages. The study examined this issue via assessing peak alpha frequency (PAF), a measure previous studies, have indicated as abnormal ASD. magnetoencephalographic (MEG) data were obtained from 141 TDC (6.13–17.70 years) and 204 (6.07–17.93 years). A source model 15 regional sources...
Auditory processing and language impairments are prominent in children with autism spectrum disorder (ASD). The present study integrated diffusion MR measures of white-matter microstructure magnetoencephalography (MEG) cortical dynamics to investigate associations between brain structure function within auditory systems ASD. Based on previous findings, abnormal structure-function relationships ASD were hypothesized.Evaluable neuroimaging data was obtained from 44 typically developing (TD)...
Abstract Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded magnetoencephalography (MEG), have been reported in verbal children with ASD. Association clinical measures indicates that delayed MMF components are associated poorer language and communication performance. At present, little is known about correlates of skills extremely impaired ( minimally‐verbal/non‐verbal) who ASD: ASD‐MVNV. It hypothesized delays observed language‐impaired but...
We examined whether modulation of functional connectivity by cognitive state differed between pre-adolescent children with Autism Spectrum Disorders (ASD) and age IQ-matched control children. Children underwent magnetic resonance imaging (fMRI) during two states, a resting followed sustained attention task. A voxel-wise method was used to characterize at levels, local (within voxel's 14 mm neighborhood) distant (outside the neighborhood rest brain) regions exhibiting Group × State...
A major motivation in designing the new infant and child magnetoencephalography (MEG) system described this manuscript is premise that electrophysiological signatures (resting activity evoked responses) may serve as biomarkers of neurodevelopmental disorders, with neuronal abnormalities conditions such autism spectrum disorder (ASD) potentially detectable early development. Whole-head MEG systems are generally optimized/sized for adults. Since magnetic field produced by currents decreases a...
We and others have demonstrated the resting-state (RS) peak alpha frequency (PAF) as a potential clinical marker for young children with autism spectrum disorder (ASD), previous studies observing higher PAF in school-age ASD versus typically developing (TD) children, well an association between RS measures of processing speed TD but not ASD. The brain mechanisms associated these findings are unknown. A few found that more mature optic radiation white matter is PAF. Other reported neural...
Abstract Individuals with autism have an atypical pattern of visual processing. Various studies provided evidence that individuals perceive the details stimuli before gestalt, reverse typical This study used Rey Osterreith Complex Figure (ROCF) task and objective scoring system to examine local/global processing approaches its reproduction in 37 diagnosed high‐functioning (HFA) compared 49 age‐, IQ‐, gender‐matched typically developing controls (TD). The sample was divided into children...
Individuals with the 16p11.2 BP4–BP5 copy number variant (CNV) exhibit a range of behavioral phenotypes that may include mild impairment in cognition and clinical diagnoses autism spectrum disorder (ASD). To better understand auditory processing impairments populations this chromosomal variation, evoked responses were examined children deletion, duplication, age-matched controls. Stimuli consisted sinusoidal binaural tones presented passively while underwent recording magnetoencephalography...
The M50 and M100 auditory evoked responses reflect early processes in the primary/secondary cortex. Although previous studies have been conducted on individuals with autism spectrum disorder (ASD) indicate disruption of encoding simple sensory information, analogous investigations neural correlates processing through development from children into adults are very limited. Magnetoencephalography was used to record signals arising left right superior temporal gyrus during presentation tones...
Studies suggest that individuals with autism spectrum disorder (ASD) exhibit altered electrophysiological alpha to gamma phase-amplitude coupling (PAC). Preliminary reports small samples report conflicting findings regarding the directionality of PAC alterations in ASD. The present study examined resting-state activity throughout brain a relatively large sample 119 children ASD and 47 typically developing children. Children demonstrated regionally specific abnormalities low-gamma PAC,...
Background Children who have Autism Spectrum Disorder (ASD) show preferences for processed foods, such as salty and sugary snacks (SSS) sugar-sweetened beverages (SSB), while healthier fruits vegetables (FV), are consumed less. Innovative tools needed that can efficiently disseminate evidence-based interventions engage autistic children to improve their diet. Aim The aim of this 3-month randomized trial was test the initial efficacy a mobile health (mHealth) nutrition intervention on...