A5004097414- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Prenatal Substance Exposure Effects
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Alcohol Consumption and Health Effects
- Birth, Development, and Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Diet, Metabolism, and Disease
- Alzheimer's disease research and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Parkinson's Disease Mechanisms and Treatments
- Aging, Health, and Disability
- Alcoholism and Thiamine Deficiency
- Memory and Neural Mechanisms
- Fungal Infections and Studies
- Bipolar Disorder and Treatment
- Pancreatic function and diabetes
- Obsessive-Compulsive Spectrum Disorders
- Biochemical Analysis and Sensing Techniques
- Health and Lifestyle Studies
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
Universitat de Miguel Hernández d'Elx
2015-2025
Instituto de Salud Carlos III
2015-2025
Instituto de investigación sanitaria y biomédica de Alicante
2022-2025
Instituto de Neurociencias
2008-2025
Hospital General Universitario de Alicante Doctor Balmis
2022-2024
Federación Española de Enfermedades Raras
2014-2024
Universidad de Málaga
2024
Junta de Andalucía
2024
Hospital General Universitario Gregorio Marañón
2009-2019
Consejo Superior de Investigaciones Científicas
2015-2017
Abstract This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The CBD (60 mg/kg, i.p.) blood concentration, hypothermia handling‐induced convulsions associated to acute administration were evaluated. two‐bottle choice paradigm was performed assess (30, 60 120 mg/kg/day, intake preference. In addition, an oral self‐administration experiment carried out evaluate [a single s.c. a microparticle formulation providing continuous...
Migraine is a highly prevalent neurological disorder. Among the risk factors identified, psychiatric comorbidities, such as depression, seem to play an important role in its onset and clinical course. Patients with migraine are 2.5 times more likely develop depressive disorder; this becomes even higher patients suffering from chronic or aura. This relationship bidirectional, since depression also predicts earlier/worse of migraine, increasing chronicity and, consequently, requiring...
In Brief this study, we investigated the role of endocannabinoid system (ECS) in emotional and cognitive alterations associated with osteoarthritis pain. The monosodium iodoacetate model was used to evaluate affective manifestations pain type 1 (CB1R) 2 (CB2R) cannabinoid receptor knockout wild-type mice ability CB1R (ACEA) CB2R (JWH133) selective agonists improve these during a 3-week time period. levels endocannabinoids anandamide (AEA) 2-arachidonoylglycerol (2-AG) were measured plasma...
This study examines the role of cannabinoid CB2 receptor (CB2r) on vulnerability to ethanol consumption. The time-related and dose-response effects rectal temperature, handling-induced convulsions (HIC) blood concentrations were evaluated in CB2KO wild-type (WT) mice. reinforcing properties conditioned place preference (CPP), voluntary consumption oral self-administration. Water-maintained behavior schedule was performed evaluate degree motivation induced by a natural stimulus. Preference...
Abstract This study employs an oral operant conditioning paradigm to evaluate the effects of repeated social defeat during adolescence on reinforcing and motivational actions ethanol in adult OF 1 mice. Social interaction, emotional cognitive behavioral aspects were also analyzed, real‐time polymerase chain reaction ( PCR ) experiments performed gene expression changes mesocorticolimbic hypothalamus‐hypophysis‐adrenal HHA axis. did not alter anxiety‐like behavior elevated plus maze or...
Adolescence is a critical period for brain maturation in which this organ undergoes plasticity mechanisms that increase its vulnerability to the effects of alcohol. Significantly, ethanol-induced disruption hippocampal neurogenesis has been related cognitive decline adulthood. During adolescence, perineuronal nets (PNNs), extracellular matrix structures highly affected by ethanol consumption, plays fundamental role and hippocampus. Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ anchor...
This study evaluated gene expression differences between two mouse strains, characterized by opposite impulsivity-like traits and the involvement of cannabinoid CB(2) receptor in modulation impulsivity.Behavioural tests were conducted to compare motor activity, exploration novelty seeking, attention cognitive impulsivity (delayed reinforcement task: session duration 30 min; timeout s) A/J DBA/2 mice. Expression genes for dopamine D(2) receptors, CB(1) receptors measured cingulate cortex...
Thyroid hormones are fundamental for the expression of genes involved in development CNS and their deficiency is associated with a wide spectrum neurological diseases including mental retardation, attention deficit-hyperactivity disorder autism disorders. We examined rat whether developmental early postnatal hypothyroidism affects distribution vesicular glutamate transporter-1 (VGluT1; glutamatergic) inhibitory amino acid transporter (VGAT; GABAergic) immunoreactive (ir) boutons hippocampus...