A5057198391- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Ischemia and Reperfusion
- Advanced Neuroimaging Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- NMR spectroscopy and applications
- Aortic Thrombus and Embolism
- Elasticity and Material Modeling
- Advanced Glycation End Products research
Massachusetts General Hospital
2024
Harvard University
2024
Valve (United States)
2022
Children's Hospital of Philadelphia
2020-2022
Philadelphia University
2022
Drexel University
2011-2016
Valvular heart diseases are associated with significant cardiovascular morbidity and mortality, often require surgical and/or percutaneous repair or replacement. Valve replacement is limited to mechanical biological prostheses, the latter of which circumvent need for lifelong anticoagulation but subject structural valve degeneration (SVD) failure. Although calcification heavily studied, noncalcific SVD, represent roughly 30% BHV failures, relatively underinvestigated. This original work...
Objectives Replacement aortic valves endeavor to mimic native valve function at the organ, tissue, and in case of bioprosthetic valves, cellular levels. There is a wealth information about macro micro structure; however, there presently limited on morphology whole fiber architecture. The objective this study was provide qualitative quantitative analyses leaflet bundle branching patterns using novel imaging system. Methods We developed custom automated microscope system with motor control....
Significance Heart valve disease affects millions, and since there is no effective medical therapy, surgical repair when possible—or more commonly, replacement—are the only treatments available. Bioprosthetic heart valves (BHV), most frequently used replacements, are composed of heterograft tissue, typically fixed in glutaraldehyde, prepared for human use either as surgically implantable devices or transcatheter delivery. Protein-glycation limits durability BHV, contributing to device...
Bioprosthetic heart valves (BHV) fabricated from heterograft tissue, such as glutaraldehyde pretreated bovine pericardium (BP), are the most frequently used valve replacements. BHV durability is limited by structural degeneration (SVD), mechanistically associated with calcification, advanced glycation end products (AGE), and serum protein infiltration. We investigated hypothesis that anti-AGE agents, Aminoguanidine, Pyridoxamine [PYR], N-Acetylcysteine could mitigate AGE-serum SVD mechanisms...
ABSTRACT Current techniques to image the microstructure of heart with diffusion tensor MRI (DTI) are highly under-resolved. We present a technique improve spatial resolution cardiac DTI by almost 10-fold and leverage this measure local gradients in cardiomyocyte alignment or helix angle (HA). further introduce phenomapping approach based on voxel-wise hierarchical clustering these identify distinct microstructural microenvironments heart. Initial development was performed healthy volunteers...
This study describes a method to acquire submillimeter resolution diffusion tensor MRI scans of the human heart in vivo. Imaging was performed healthy controls and patients with severe high flow-high gradient aortic stenosis. The images were processed generate helix angle maps cardiomyocyte orientation compared. range angles across myocardium higher subjects stenosis relative slope also increased
Motivation: Diffusion tensor imaging of the heart can be performed with sub-mm resolution. However, established metrics do not fully take advantage this improved Goal(s): We aimed to determine whether local gradients in helix angle (HA) could calculated and used characterize microstructural response load imposed by aortic stenosis. Approach: Voxel-wise maps radial, circumferential, minimum maximum HA were generated. Results: The radial gradient was reduced stenosis, but coherence well...
Motivation: DTI data in the heart are currently averaged to yield per-patient values that cannot detect local variations microstructural microenvironment. Goal(s): We aimed develop a voxel-based phenomapping approach cluster voxels myocardium into distinct groups based on their properties. then used compare subjects with aortic stenosis (AS) age-matched controls (CTL). Approach: A population matrix of was created using z-score normalization and evaluated k-means clustering (k=4). Results: 4...
Abstract Background Bioprosthetic heart valves (BHV) are widely used to treat valve disease but fundamentally limited by structural degeneration (SVD). Non-calcific mechanisms of SVD entirely account for approximately 30% cases and contribute calcific remain understudied. Glycation have not been previously associated with SVD, despite being established as degenerative in collagenous native tissues. Objectives To determine whether blood component infiltration-based glycation concomitant human...
The Computational Imaging and Biomechanics Lab(CIBL) at Drexel University has been continuously researching the mechanical properties of soft tissues, specifically tendon heart valves. Our current effort is on a new testing device scaled down for individual fascicles also known as mesostructure-scale. This paper presents preliminary results that system capturing electrospun scaffolds.
Current bioprosthetic and mechanical designs or heart valve replacements do not fully consider the underlying native fibre structure of valve, nor their fibre-scale properties. The overall goal this work is to perform experimental analytical analyses individual fiber membrane "Mesostructures" aortic valve. We have developed a novel experimental/analytical system investigate properties these structures in detail. More successful treatments damaged diseased valves require new experiments...
ABSTRACT Bioprosthetic heart valves (BHV) are fabricated from glutaraldehyde cross-linked heterograft tissue, such as bovine pericardium (BP) or porcine aortic valves. BHV develop structural valve degeneration (SVD), often with calcification, requiring replacement. Advanced glycation end products (AGE) post-translational, non-enzymatic carbohydrate protein modifications. AGE present in SVD-BHV clinical explants and not detectable unimplanted BHV. Here, we studied the hypothesis that...
Abstract Bioprosthetic heart valves (BHV) fabricated from glutaraldehyde pretreated heterograft tissue, such as bovine pericardium (BP) are the most commonly used valve replacements. However, BHV durability is limited by structural degeneration (SVD) resulting both calcification and advanced glycation end product (AGE) deposition together with serum protein infiltration. In present study we investigated hypothesis that anti-AGE agents, Aminoguanidine (AG), Pyridoxamine (PYR),...
Introduction: Bioprosthetic heart valves (BHV) fabricated from glutaraldehyde pretreated bovine pericardium (BP), are the most commonly used valve replacements. However, BHV durability is limited by structural degeneration (SVD) resulting both calcification and advanced glycation end product (AGE) deposition together with serum protein infiltration. This study investigated, for first time, application of anti-glycation agents as a way to mitigate AGE-related BHV. Hypothesis: We investigated...