A5034314741- Glioma Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Immune cells in cancer
- Tryptophan and brain disorders
- T-cell and B-cell Immunology
- High-Velocity Impact and Material Behavior
- Gut microbiota and health
- Immune Response and Inflammation
- Structural Response to Dynamic Loads
- Neurological Disease Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- Synthesis and properties of polymers
- Cancer Immunotherapy and Biomarkers
- Epoxy Resin Curing Processes
- Thermal and Kinetic Analysis
- Histone Deacetylase Inhibitors Research
- Nerve Injury and Rehabilitation
- Structural Analysis of Composite Materials
- Neuroendocrine regulation and behavior
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
Taipei Medical University
2021-2025
Taipei Medical University Hospital
2017-2025
Duke University Hospital
2025
Duke Medical Center
2025
Kainan University
2017
The University of Texas MD Anderson Cancer Center
2015
Institute of Molecular Biology, Academia Sinica
2011-2014
Naval Surface Warfare Center
1981-2011
National Yang Ming Chiao Tung University
2011
National Taiwan University
2007-2008
Recent studies have proposed several gene signatures as biomarkers for different grades of gliomas from various perspectives. However, most these genes can only be used appropriately patients with specific gliomas. In this study, we aimed to identify survival-relevant shared between glioblastoma multiforme (GBM) and lower-grade glioma (LGG), which could potential classify into risk groups. Cox proportional hazard regression model (Cox model) was extract relative genes, effectiveness...
Maternal immune activation (MIA) increases the risk of autism spectrum disorder (ASD) in offspring. Microbial dysbiosis is associated with ASD symptoms. However, alterations brain-gut-microbiota axis lipopolysaccharide (LPS)-induced MIA offspring remain unclear. Here, we examined social behavior, anxiety-like and repetitive microbiota profile, myelination levels LPS-induced rat Compared control offspring, male spent less time an active interaction stranger rats, displayed more had...
Characterization of immunophenotypes in glioblastoma (GBM) is important for therapeutic stratification and helps predict treatment response prognosis. Radiomics can be used to molecular subtypes gene expression levels. However, whether radiomics aids immunophenotyping prediction still unknown. In this study, classify patients with GBM, we developed machine learning-based magnetic resonance (MR) radiomic models evaluate the enrichment levels four immune subsets: Cytotoxic T lymphocytes...
Abstract Background Glioblastoma multiforme (GBM) is an aggressive brain tumor with chemoresistant, immunosuppressive, and invasive properties. Despite standard therapies, including surgery, radiotherapy, temozolomide (TMZ) chemotherapy, tumors inevitably recur in the peritumoral region. Targeting GBM-mediated immunosuppressive properties a promising strategy to improve clinical outcomes. Methods We utilized genomic data from Taiwan GBM cohort The Cancer Genome Atlas (TCGA) analyze RNA...
Myb family transcription factors are important in regulating cell proliferation, differentiation, and cycle progression. Giardia lamblia differentiates into infectious cysts to survive outside of the host. During encystation, genes encoding cyst wall proteins (CWPs) coordinately induced. We have identified an encystation-induced Myb2 protein, which binds promoter regions cwp myb2 itself vitro. To elucidate role G. lamblia, we tested hypothesis that can activate genes. found overexpression...
NK cell development requires IL-15, which is "trans-presented" to IL-15Rβγ on cells by IL-15Rα other cells. In this study, we report that different levels of IL-15 trans-presentation are required for developmental events reach full maturation status. Because the intracellular domain has capacity recruit signaling molecules, generated knockin and transgenic (Tg) mice lack assess role level independent function domain. The various these follows order WT > Tg6 Tg1 ≥ knockout. Bone marrow...
Abstract NK cell development and homeostasis require IL-15 produced by both hematopoietic parenchymal cells. Certain sources, such as macrophages dendritic cells, are known, whereas the source of remains elusive. Using two types adipocyte-specific Il15−/− mice, we identified adipocytes a that supported nonredundantly. Both mice showed reduced production specifically in adipose tissue but impaired spleen liver addition to tissue. We also found harbored progenitors other niches (e.g. spleen)...
Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit from Epidermal growth factor receptor (EGFR)-targeted therapies, we introduce lipid-encapsulated SPIO and hypothesized that anti-EGFR antibody cetuximab conjugated of such can be used to EGFR-positive glioblastomas in non-invasive T2 MR assays. The newly introduced lipid-coated SPIOs,...
Study Design. A case series of spinal arthrodesis performed with vascularized fibular grafts is presented. Objectives. The use to obtain anterior fusion in patients complex disorders and poor environments described. Summary Background Data. success dependent on numerous factors, such as the substrate used for (i.e., graft), biology bed, local host factors. Vascularized have higher rates union can better overcome a bed than nonvascular grafts. However, they are associated donor site morbidity...
Purpose: Targeted superparamagnetic iron oxide (SPIO) nanoparticles are a promising tool for molecular magnetic resonance imaging (MRI) diagnosis. Lipid-coated SPIO have nonfouling property that can reduce nonspecific binding to off-target cells and prevent agglomeration, making them suitable contrast agents MRI PD-L1 is poor prognostic factor patients with glioblastoma. Most recurrent glioblastomas temozolomide resistant. Diagnostic probes targeting could facilitate early diagnosis be used...
Giardia lamblia causes waterborne diarrhoea by transmission of infective cysts. Three cyst wall proteins are highly expressed in a concerted manner during encystation trophozoites into However, their gene regulatory mechanism is still largely unknown. DNA topoisomerases control topological homeostasis genomic replication, transcription and chromosome segregation. They involved variety cellular processes including cell cycle, proliferation differentiation, so they may be valuable drug...
Sjögren's syndrome (SS) is an autoimmune disease and its conventional treatment has exhibited limited therapeutic efficacy. Traditional Chinese medicine been demonstrated to ameliorate the sicca symptoms of SS by decreasing level TH1 TH2 cytokines increasing salivary flow rate. A newly designed traditional medicine, SS-1, showed improved efficacy in alleviating dryness patients National Taiwan cohort investigation. Here, we investigated effect SS-1 on T cell responses. was authenticated...
The molecular heterogeneity of gene expression profiles glioblastoma multiforme (GBM) are the most important prognostic factors for tumor recurrence and drug resistance. Thus, aim this study was to identify potential target genes related temozolomide (TMZ) resistance GBM recurrence. genomic data patients with from Cancer Genome Atlas (TCGA; 154 primary 13 recurrent tumors) a local cohort (29 4 tumors), samples different regions 25 peritumoral regions), Gene Expression Omnibus (GSE84465,...
Abstract The glass transition temperature as an additive property was studied on a series of epoxy/amine crosslinked polymers. Various methods from the literature analyzing in terms components are presented and then judged to determine which these gives best agreement between calculated measured temperature. It found that predictions agree average with measurements within accuracy measurements, approximately 3%.
Benzimidazoles have attracted much attention over the last few decades due to their broad-spectrum pharmacological properties. Increasing evidence is showing potential use of benzimidazoles as anti-angiogenic agents, although mechanisms that impact angiogenesis remain be fully defined. In this study, we aim investigate MFB, a novel 2-aminobenzimidazole derivative, develop inhibitor.MTT, BrdU, migration and invasion assays, immunoblotting were employed examine MFB's effects on vascular...
Demonstration of Complex Coronary-Pulmonary Artery Fistula by MDCT and Correlation with Coronary AngiographyMonica S. M. Chan1 2, Ivan Y. F. Chan1, K. H. Fung1, Gilbert Lee1, L. Tsui3 T. C. Leung3Audio Available | Share
The capacity to synthesize a protective cyst wall is critical for infectivity of Giardia lamblia. It interest know the mechanism coordinated synthesis three proteins (CWPs) during encystation, differentiation process. Multiprotein bridging factor 1 (MBF1) gene family group transcription coactivators that bridge various factors. They are involved in cell growth and yeast animals, or stress response fungi plants. We asked whether has MBF1-like genes their products influence expression. BLAST...
In this study, a middle cerebral artery (MCA) occlusion mouse model is employed to study ischemia-reperfusion. A reproducible and reliable useful for investigating the pathophysiology of ischemia-reperfusion determining potential therapeutic strategies patients with stroke. Variations in anatomy circle Willis C57BL/6 mice affects their infarct volume after cerebral-ischemia-induced injury. Studies have indicated that distal MCA (MCAO) can overcome problem result stable size. we establish...