A5023322159- Tendon Structure and Treatment
- Veterinary Equine Medical Research
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Sedative Agents
- Microbial Metabolic Engineering and Bioproduction
- Sports injuries and prevention
- Anesthesia and Pain Management
- Mesenchymal stem cell research
- Metabolism and Genetic Disorders
- Enzyme Structure and Function
- Cellular Mechanics and Interactions
- thermodynamics and calorimetric analyses
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Musculoskeletal synovial abnormalities and treatments
- Amino Acid Enzymes and Metabolism
- Infrared Thermography in Medicine
- Veterinary Oncology Research
- Cocoa and Sweet Potato Agronomy
- Shoulder Injury and Treatment
- Peripheral Nerve Disorders
- Nuts composition and effects
- Anesthesia and Neurotoxicity Research
University of Pennsylvania
2025
MSH Medical School Hamburg – University of Applied Sciences and Medical University
2024
Universität Hamburg
2020-2024
The Ohio State University
2023-2024
John Wiley & Sons (United States)
2023
Texas A&M University
2021
University of Georgia
2015-2017
Summary Penetrating foot injuries in horses pose significant diagnostic and therapeutic challenges, particularly when deeper synovial structures are involved. A systematic approach to imaging early aggressive management is essential achieve a good outcome. While superficial wounds may resolve with conservative treatment, carry high risk of complications, including osteomyelitis sepsis. Radiography, magnetic resonance (MRI), computed tomography (CT) play crucial role assessing the extent...
The goal of this study was to establish an SPIO-based cell-tracking method in ovine model tendonitis and determine if may be useful for further cellular therapies vivo. Functional assays were performed on labeled unlabeled cells ensure that no significant changes induced by intracellular SPIOs. Following biosafety validation, tendon lesions mechanically (n = 4) or chemically four sheep scanned ex vivo at 7 14 days the presence distribution intralesional cells. Ovine MSCs with 50 µg SPIOs/mL...
Ultrasound‐guided intralesional injection of mesenchymal stem cells (MSCs) is held as the benchmark for cell delivery in tendonitis. The primary objective this study was to investigate immediate distribution following MSCs. Unilateral superficial digital flexor tendon (SDFT) lesions were created forelimb six horses and injected with 10 × 6 MSCs labeled superparamagnetic iron oxide nanoparticles (SPIOs) under ultrasound guidance. Assays performed confirm that there no significant changes...
Abstract OBJECTIVE The objective of this study was to optimize an MRI-based diffusion tensor imaging (DTI) protocol for the plantar nerves at level tarsus in normal equine limbs. SAMPLE 12 pelvic cadaver limbs from horses without evidence proximal suspensory pathology were imaged with a 3T MRI system. METHODS For diffusion-weighted imaging, b values 600, 800, and 1,000 s/mm 2 tested. Data processed DSI Studio. Cross-sectional areas medial lateral nerve along recorded. length number fiber...
To determine the minimum alveolar concentration that blunts adrenergic responses (MACBAR) for isoflurane and evaluate effects of fentanyl on MACBAR in sheep. ANIMALS 13 healthy adult Dorset-cross ewes.In a crossover design, each ewe was anesthetized 2 times determination MACBAR. Anesthesia induced with propofol administered IV. Sheep initially received (5 μg/kg, IV, followed by constant rate infusion 5 μg/kg/h) or an equivalent volume saline (0.9% NaCl) solution (control treatment). After...
To determine the short-term effect of plantar fasciotomy and neurectomy (PFN) deep branch lateral nerve on proximal suspensory ligament (PSL) cross-sectional area (CSA) in horses with hindlimb desmopathy (PSD).Analytical, observational, cohort study.Twenty-one horses.Records chronic PSD treated by PFN were included if a preoperative ultrasonographic examination was available at least one postoperative examination. One masked observer measured PSL. Intraobserver reliability determined...
Studying the metabolic role of non-essential promiscuous enzymes is a challenging task, as genetic manipulations usually do not reveal at which point(s) network enzymatic activity such protein beneficial for organism. Each HAD-like phosphatases YcsE, YitU and YwtE Bacillus subtilis catalyzes dephosphorylation 5-amino-6-ribitylamino-uracil 5'-phosphate, essential in biosynthesis riboflavin. Using CRISPR technology, we have found that deletion these genes, individually or all possible...
Deep digital flexor tendinopathy is a significant cause of lameness and poor performance in equine athletes with substantial implications for their return to athletic performance. Magnetic resonance imaging (MRI) increasingly integrated into the diagnostic workup horses foot pain has revolutionized diagnosis management these injuries. This review discusses principles MRI context DDFT injury, comparing high-field low-field systems, highlighting clinical relevance technical parameters...
Riboflavin analogs lacking one methyl group (7α or 8α) can still serve as a surrogate for riboflavin in riboflavin-deficient microorganisms animals. The absence of both groups at once completely abolishes this substitution capability. To elucidate the molecular mechanisms behind phenomenon, we performed an adaptive laboratory evolution experiment (in triplicate) on E. coli strain auxotrophic riboflavin. As result, requirement was reduced ~10-fold presence 7,8-didemethyl-riboflavin. whole...
A dog was evaluated for right pelvic limb lameness. Computed tomography and magnetic resonance imaging revealed an irregular, contrast-enhancing mass extending along the proximolateral tibia, involving long digital extensor tendon (LDET) ± cranial tibialis muscle. Pulmonary nodules, nonspecific hepatomegaly, splenic nodules were also present. The primary differential diagnosis soft tissue neoplasia. Surgical biopsy with histopathology benign, chronic inflammation, fibrosis. Idiopathic...