A5101533609- Ferroptosis and cancer prognosis
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Nerve injury and regeneration
- Phytochemical compounds biological activities
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Aluminum toxicity and tolerance in plants and animals
- Bacterial Infections and Vaccines
- Mechanisms of cancer metastasis
- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- Inflammatory Biomarkers in Disease Prognosis
- Biosensors and Analytical Detection
- Infective Endocarditis Diagnosis and Management
- Signaling Pathways in Disease
- TGF-β signaling in diseases
- Inflammatory mediators and NSAID effects
- Lung Cancer Research Studies
- FOXO transcription factor regulation
- Plant Micronutrient Interactions and Effects
- Advanced Biosensing Techniques and Applications
- Cytokine Signaling Pathways and Interactions
First Hospital of China Medical University
2020-2024
China Medical University
2019-2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
First People's Hospital of Nanning
2024
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2023
Xian Central Hospital
2023
Capital Medical University
2017-2020
Shenyang Fifth People Hospital
2019
OBJECTIVE: To develop and characterise an animal model of paralytic neuropathy after Campylobacter jejuni infection. infection precedes development many cases Guillain-Barré syndrome is particularly associated with having prominent axonal degeneration. Understanding the pathogenesis C has been slowed by lack models. METHODS: A spontaneous described that developed in chickens from farms four patients syndrome. The production experimentally fed isolated one these reported. sciatic nerves...
Background: NOS3 (endothelial NOS, eNOS ) is a member of the nitric oxide synthase (NOS) enzyme family, mainly participating in (NO) generation. has been reported to inhibit apoptosis and promote angiogenesis, proliferation, invasiveness. However, expression pattern its diagnostic prognostic potential not investigated pan-cancer perspective. Methods: Data from Genotype-Tissue Expression (GTEx), Cancer Genome Atlas (TCGA), Cell Line Encyclopedia (CCLE), Therapeutics Response Portal (CTRP)...
Ovarian cancer (OC) is one of the most lethal gynecological malignancies. This study aimed to identify biomarkers that were sensitive platinum-based chemotherapeutic agents and can be used in immunotherapy explore importance their mechanisms action.RNA-seq profiles clinicopathological data for OC samples obtained from The Cancer Genome Atlas (TCGA) cBioPortal platform, respectively. Platinum-sensitive platinum-resistant TCGA cohort selected based on clinical information. RNA-seq 70...
Luteolin, a monomeric substance, is natural product of the Brucea javanica (BJ) plant. oil emulsion injection (BJOEI) proprietary Chinese medicine purified from BJ that widely used clinically as an anti-tumor treatment. Although growing body research suggests luteolin and BJOEI have effects, molecular mechanism action has not been fully elucidated. In this study, through docking technology, we found can interact directly with GPSM2 regulate FoxO signaling pathway GPSM2. addition, inhibitory...
Background The differential diagnosis between postneurosurgical bacterial meningitis and aseptic remains challenging both for the clinician laboratory. Combinations of markers, as opposed to single ones, may improve thereby survival. Methods This prospective cohort study included patients with suspected after neurosurgery. were divided into two groups according diagnostic criteria involving a group group. Four biomarkers, including cerebrospinal fluid procalcitonin, lactate, interleukin-8...
Peritoneal dissemination threatens the survival of patients with gastric cancer (GC). Bufalin is an extract traditional Chinese medicine, which has been proved to have anticancer effect. The target bufalin in suppressing peritoneal (GCPD) and underlying mechanism are still unclear. In this research, GC cell line MGC-803 high-potential MKN-45P were treated or L-NAME. Malignant biological behavior protein level lines detected MTT, wound healing, transwell, adhesion, western blotting....
The 5-year survival rate of diffuse large B-cell lymphoma (DLBCL) can reach 60%. However, nearly half patients undergo relapse/refractory issues with a period less than 2 years. New therapeutic approaches are therefore needed to improve chemotherapy efficacy and patient survival. Bufalin (BF), isolated from the traditional Chinese medicine Chansu, has been reported play an anticancer role in multiple cancer cell types. there few reports effects BF on growth DLBCL. In present study, we...
Epithelial ovarian cancer (EOC) has a poor prognosis and high mortality rate; patients are easy to relapse with standard therapies. So, there is an urgent need develop novel drugs. In this study, differentially expressed genes (DEGs) of EOC were identified in The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Enrichment protein-protein interaction (PPI) analyses performed. drug candidate which the possibility treat was predicted by Connectivity Map (CMAP) Moreover,...
Abstract Introduction Numerous types of infection were closely related to GBS , mainly including Campylobacter jejuni Cytomegalovirus, which may lead the production anti‐gangliosides antibodies ( AGA ) . Currently, although there are increased studies on and a few anti‐ CMV in association between them remains poorly documented. Therefore, our research aims analyze correlation Methods A total 29 patients with enrolled this study. The tested by electrochemiluminescence immunoassay “ ECLIA ”...
The potential of obtaining incremental diagnostic information using a parallel assay is attractive.
We investigated the prognostic significance of carcinoembryonic antigen (CEA) and vascular endothelial growth factor (VEGF) their associations with clinicopathological features in patients sigmoid colon carcinoma (SCC).We retrospectively reviewed SCC treated curative surgery from January 2001 to June 2010 at our hospital. Patients' general, clinical, histopathologic, serum biomarkers were analyzed. measured VEGF 176 sets tissues adjacent noncancerous tissue samples immunohistochemical...
The aim was to observe the effect of Toll-like receptor 4 (TLR4) deficiency on clinical severity and expression Th1/Th2/Th17-associated cytokines in experimental autoimmune neuritis (EAN).We selected C57BL/10 wild type (WT) mice TLR4 knockout (KO) with background for induction EAN model by immunizing twice (days 0 8) via subcutaneous injection 180 μg P0 peptide 180-199 emulsion 25 μl PBS 0.5 mg Mycobacterium tuberculosis (Difco, USA) Freund's incomplete adjuvant into back mice....
Abstract Background: NOS3 (endothelial NOS, eNOS) is a member of the nitric oxide synthase (NOS) enzyme family, mainly participating in (NO) generation. has been reported to inhibit apoptosis and promote angiogenesis, proliferation, invasiveness. However, expression pattern its diagnostic prognostic potential not investigated pan-cancer perspective. Methods: In this research, data from Genotype-Tissue Expression (GTEx), Cancer Genome Atlas (TCGA), Cell Line Encyclopedia (CCLE) Therapeutics...
Abstract Background Metastases are uncommon in intraventricular tumors. Intraventricular metastases from lung cancer extremely rare and present challenges terms of diagnosis management. Case Presentation: We the case a 52-year-old man who presented with multiple lesions on CT MRI. A scan, needle biopsy, pathological examination confirmed small cell cancer. The patient received chemotherapy anti-PD-L1 blockade, along etoposide platinum (EP). As result, size tumor was significantly reduced....
Abstract Background: Glioma is the most common primary tumor of central nervous system with a poor survival rate. There has been evidence showing that immune microenvironment influences glioma patient outcomes. Therefore, we established novel immune-related gene prognosis model to explore relationship between immunity and prognosis. Methods: The scores samples in TCGA CGGA databases were analyzed by ESTIMATE, then genes identified weighted co-expression network analysis (WGCNA). Seven...