A5004651439- Urological Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Pelvic floor disorders treatments
- Renal and related cancers
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diverse Topics in Contemporary Research
- Conferences and Exhibitions Management
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Diverse Aspects of Tourism Research
- Transgenic Plants and Applications
- Pluripotent Stem Cells Research
- Biomedical Ethics and Regulation
- Hernia repair and management
- Technology Adoption and User Behaviour
- Sport and Mega-Event Impacts
- Prenatal Screening and Diagnostics
- Hospitality and Tourism Education
- Consumer Retail Behavior Studies
- Education and Learning Interventions
- Digital Marketing and Social Media
Sri Balaji Vidyapeeth University
2024-2025
Stanford University
2013-2025
California Institute for Regenerative Medicine
2016-2017
Pacific Dental College and Hospital
2015
There is great interest in using stem cells (SC) to regenerate a deficient urethral sphincter patients with urinary incontinence. The smooth muscle component of the significant contributor function. However, current translational efforts for restoration focus only on skeletal regeneration because they rely adult mesenchymal SC as cell source. These do not yield sufficient (SMCs) transplantation. We may be able overcome this limitation by pluripotent (PSC) derive SMCs. Hence, we sought...
A first-in-human (FIH) Phase 1 clinical trial with a novel regulatory T (Treg) cell therapy product to treat IPEX syndrome is ongoing (NCT05241444) at our center. We administer autologous engineered CD4LVFOXP3 Treg-like cells, lentiviral vector (LV)-transduced CD4+ cells expressing wild-type human FOXP3. Primary objectives include feasibility and safety. Our secondary objective assess the impact of infusion on manifestations. The study 2 + 4 dose escalation design 3 doses in two different...
Forkhead box P3 (FOXP3) is an essential transcription factor for regulatory T cell (Treg) function. Defects in Tregs mediate many immune diseases including the monogenic autoimmune disease dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), which caused by FOXP3 mutations. Treg products are a promising modality to induce allograft tolerance or reduce use of immunosuppressive drugs prevent rejection, as well treatment acquired diseases. We have recently opened phase I...
Abstract We aimed to derive induced pluripotent stem cell (iPSC) lines from vaginal fibroblasts older women with pelvic organ prolapse. examined the effect of donor age on iPSCs and cells redifferentiated these iPSCs. Vaginal were isolated younger subjects for reprogramming. generated simultaneously using an excisable polycistronic lentiviral vector expressing Oct4, Klf4, Sox2, cMyc. The markers confirmed by immunocytochemistry quantitative reverse transcription-polymerase chain reaction...
Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth pathologies. However, the therapeutic potential of pSMCs derived men and women may be very different. Cell sex can exert a profound impact on differentiation process into somatic cells. In spite advances in translation cell technologies, role effect hormones towards mesenchymal lineage remain largely unexplored. Using...
Abstract Data suggest that myoblasts from various sources, including bone marrow, skeletal muscle, and adipose tissue, can restore muscle function in patients with urinary incontinence. Animal data have indicated these progenitor cells exert mostly a paracrine effect on the native tissues rather than cell regeneration. Limited knowledge is available vivo of human stem or progenitors injured muscles. We examined integration smooth (pSMCs) derived pluripotent (hPSCs). pSMCs were embryonic line...
Abstract Human-induced pluripotent stem cells (hiPSCs)-based cell therapy holds promise for treating stress urinary incontinence (SUI). However, safety concerns, especially tumorgenic potential of residual undifferentiated in hiPSC derivatives, are major barriers its clinical translation. An efficient, fast and clinical-scale strategy purifying committed is also required. Our previous studies demonstrated the regenerative effects hiPSC-derived smooth muscle progenitor (pSMCs) on injured...
The study is undertaken to understand the importance of English language skills in Indian hospitality industry, and gaps therein. It studies challenge as it exists Pune city, how AISSMS College Hotel Management & Catering Technology has attempted address issue(s). aims at gathering primary information by means questionnaires. sheds light on gap between existing desired standards proficiency. also highlights attempts three important stakeholders order issue. Though, are made from teachers...