A5034479560- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Brain Metastases and Treatment
- Neurological disorders and treatments
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Cell Image Analysis Techniques
- Language Development and Disorders
- Transcranial Magnetic Stimulation Studies
Medical College of Wisconsin
2015-2024
Froedtert Hospital
1997-2023
Neurological Surgery
1992-2022
Lutheran Hospital
1997-2022
University of Rochester
2022
Cleveland Clinic
2022
University of Cincinnati
2022
University of Alabama at Birmingham
2022
Medical University of South Carolina
2022
University of Washington
2022
The “therapeutic misconception” describes a process whereby research volunteers misinterpret the intentions of researchers and nature clinical research. This misinterpretation leads to falsely attribute therapeutic potential research, compromises informed decision making, therefore compromising ethical integrity experiment. We review recent evidence from neurobiology social cognition provide novel framework for thinking about misconception. argue that should be considered in any analysis how...
Functional magnetic resonance imaging (FMRI) is a new, noninvasive tool thought to measure changes related regional cerebral blood flow (rCBF). Previous FMRI studies have demonstrated functional within the primary cortex in response simple activation tasks, but it unknown whether can also detect nonprimary complex mental activities. We therefore scanned six right-handed healthy subjects while they performed self-paced and finger movements with right left hands. Some tasks at fixed rate (2...
Language dominance and factors that influence language lateralization were investigated in right-handed, neurologically normal subjects (n = 100) right-handed epilepsy patients 50) using functional MRI. Increases blood oxygenation-dependent signal during a semantic activation task relative to non-linguistic, auditory discrimination provided an index of system lateralization. As expected, the majority both groups showed left hemisphere dominance, although continuum asymmetry was evident, with...
<b><i>Objective:</i></b> To perform an open-label, long-term efficacy and safety/tolerability study of vagus nerve stimulation (VNS) 454 patients with refractory epilepsy. <b><i>Methods:</i></b> Subjects were enrolled from five clinical trials VNS between 1988 1995 after undergoing implantation a pulse generator in the chest left cervical nerve-stimulating lead coil. Patients assessed at 6-month intervals until device approval. Seizure frequencies, medication treatment, adverse events (AEs)...
<b><i>Background:</i></b> Left anterior temporal lobectomy (L-ATL) may be complicated by confrontation naming deficits. <b><i>Objective: </i></b> To determine whether preoperative fMRI predicts such deficits in patients with epilepsy undergoing L-ATL. <b><i>Methods:</i></b> Twenty-four L-ATL underwent language mapping fMRI, intracarotid amobarbital (Wada) testing for dominance, and pre- postoperative neuropsychological testing. laterality indexes (LIs), reflecting the interhemispheric...
Summary Purpose: Verbal memory decline is a frequent complication of left anterior temporal lobectomy (L‐ATL). The goal this study was to determine whether preoperative language mapping using functional magnetic resonance imaging (fMRI) useful for predicting which patients are likely experience verbal after L‐ATL. Methods: Sixty L‐ATL underwent with fMRI, intracarotid amobarbital (Wada) testing and lateralization, pre‐ postoperative neuropsychological testing. Demographic, historical,...
OBJECTIVE: The purpose of this study was to determine the usefulness functional magnetic resonance imaging (FMRI) map cerebral functions in patients with frontal or parietal tumors. METHODS: Charts and images tumors vascular malformations who underwent FMRI an echoplanar technique were reviewed. maps motor (11 patients), tactile sensory (12 language tasks (4 patients) obtained. location activation positive responses intraoperative cortical stimulation compared. reliability paradigms for...
OBJECTIVE: To illustrate how lesion-induced neurovascular uncoupling at functional magnetic resonance imaging (fMRI) can mimic hemispheric dominance opposite the side of a lesion preoperatively. METHODS: We retrospectively reviewed preoperative fMRI mapping data from 50 patients with focal brain abnormalities to establish patterns language, speech, visual, or motor system functions. Abnormalities included gliomas (31 patients), arteriovenous malformations (AVMs) (11 other congenital lesions...
OBJECTIVE: The purpose of this study was to determine the usefulness functional magnetic resonance imaging (FMRI) map cerebral functions in patients with frontal or parietal tumors. METHODS: Charts and images tumors vascular malformations who underwent FMRI an echoplanar technique were reviewed. maps motor (11 patients), tactile sensory (12 language tasks (4 patients) obtained. location activation positive responses intraoperative cortical stimulation compared. reliability paradigms for...
The anti-VEGF antibody, bevacizumab, is standard treatment for patients with recurrent glioblastoma. In this setting, traditional anatomic MRI methods such as post-contrast T1-weighted and T2-weighted imaging are proving unreliable monitoring response. Here we evaluate the prognostic significance of pre- posttreatment relative cerebral blood volume (rCBV) derived from dynamic susceptibility contrast to predict response bevacizumab.Thirty-six participants high-grade gliomas who underwent rCBV...
Functional magnetic resonance imaging (FMRI) has detected changes in regional cerebral blood flow and volume response to motor movements, visual stimuli, auditory stimuli each of their respective primary cortices. This experiment was conducted determine whether signal the somatosensory cortex secondary tactile stimulation could be demonstrated. The palm right hand periodically stimulated while subject undergoing echo-planar with a 1.5-T scanner equipped local gradient radio frequency coils....
Language lateralization measured by preoperative functional magnetic resonance imaging (fMRI) was shown recently to be predictive of verbal memory outcome in patients undergoing left anterior temporal lobe (L-ATL) resection. The aim this study determine whether language or the hippocampus is a better predictor setting.Thirty L-ATL underwent fMRI, hippocampal fMRI using scene encoding task, and pre- postoperative neuropsychological testing. A group 37 right ATL (R-ATL) surgery included for...
Recent conflicting reports have found both brain tumor hypercellularity and necrosis in regions of restricted diffusion on MRI-derived apparent coefficient (ADC) images. This study precisely compares ADC cell density voxel by using postmortem human whole samples. Patients with meningioma were evaluated to determine a normative distribution within benign fluid attenuated inversion recovery (FLAIR) T2/hyperintensity surrounding tumor. was used calculate minimum threshold define ADC-FLAIR...
<h3>BACKGROUND AND PURPOSE:</h3> Patients with recurrent glioblastoma often exhibit regions of diffusion restriction following the initiation bevacizumab therapy. Studies suggest that these represent either diffusion-restricted necrosis or hypercellular tumor. This study explored postmortem brain specimens and a population analysis overall survival to determine identity implications such lesions. <h3>MATERIALS METHODS:</h3> Postmortem examinations were performed on 6 patients progressively...
Abstract Objective To define left temporal lobe regions where surgical resection produces a persistent postoperative decline in naming visual objects. Methods Pre‐ and brain magnetic resonance imaging data picture (Boston Naming Test) scores were obtained prospectively from 59 people with drug‐resistant epilepsy. All patients had hemisphere language dominance at baseline underwent or ablation the lobe. Postoperative assessment occurred approximately 7 months after surgery. Surgical lesions...
Functional MRI (FMRI) was used to investigate the effect of medial temporal lobe (MTL) pathology on activation language encoding areas in patients with epilepsy (TLE).Whole-brain FMRI obtained. Twenty-eight either left TLE (LTLE) or right (RTLE) performed a semantic decision task alternating an auditory perceptual task.Activation frontal and parietal lobes similar both groups, no group differences total number active voxels. However, RTLE showed much stronger MTL, including hippocampus,...
Diffusion Tensor Imaging (DTI) is a new MRI imaging technique sensitive to directional movements of water molecules, induced by tissue barriers. This provides form contrast that allows the identification functional white matter tracts within brain, and has been proposed as suitable for presurgical planning in brain tumor patients. Resection primary tumors improves survival, performance, effectiveness adjuvant therapies, provided surgically-induced neurological deficits can be avoided....
Glioblastoma remains the most common, malignant primary cancer of central nervous system with a low life expectancy and an overall survival less than 1.5 years. The treatment options are limited there is no cure. Moreover, almost all patients develop recurrent tumors, which typically more aggressive. Therapeutically resistant glioblastoma or stem-like cells (GSCs) hypothesized to cause this inevitable recurrence. Identifying prognostic biomarkers will potentially advance knowledge about...