A5052828612- Cannabis and Cannabinoid Research
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Neurotransmitter Receptor Influence on Behavior
- Respiratory and Cough-Related Research
- Nicotinic Acetylcholine Receptors Study
- Herbal Medicine Research Studies
- Bipolar Disorder and Treatment
- Olfactory and Sensory Function Studies
- Psoriasis: Treatment and Pathogenesis
- Cancer survivorship and care
- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Reproductive System and Pregnancy
- Pharmacovigilance and Adverse Drug Reactions
- Essential Oils and Antimicrobial Activity
- Pharmacology and Obesity Treatment
- Pharmacological Effects of Natural Compounds
- Drug-Induced Adverse Reactions
- Dental Health and Care Utilization
- Natural Compound Pharmacology Studies
- Air Quality and Health Impacts
- Rheumatoid Arthritis Research and Therapies
- Biosimilars and Bioanalytical Methods
University of Messina
2016-2025
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2015-2018
Morpho (United States)
2016
Background/Objective: Major depressive disorder (MDD) is a common mental disorder, with significant portion of patients developing treatment-resistant depression (TRD). Esketamine an antagonist the N-methyl-D-aspartate receptor indicated as nasal spray in combination other antidepressants for adults TRD. Signals suspected adverse reactions (SARs) to esketamine from EudraVigilance database European countries were analyzed more defined safety profile this drug real world. Methods: SARs...
Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement Th2 cytokine interleukin-31 (IL-31) osteoporosis hadn't yet been studied. IL-31 is proinflammatory mediating multiple immune functions, whose wide range diseases, such as atopic dermatitis, bowel diseases and cutaneous lymphomas, now emerging. Given important role inflammation, we measured its serum levels postmenopausal osteoporotic patients.In fifty-six females with 26 healthy controls,...
Abstract There are many cytokines involved in the pathogenesis of osteoporosis. So far IL-33 involvement osteoporotic patients has not yet been studied. is a pro-inflammatory cytokine which mediates several immune functions; its wide range diseases, such as atopic dermatitis, asthma, and rheumatoid arthritis, now emerging. In view crucial role this inflammation bone remodeling, we measured levels serum postmenopausal women with 50 28 healthy control women, were by enzyme linked immunosorbent...
Renewed interest in natural products as potential source of drugs led us to investigate on both the anti-inflammatory and anti-nociceptive activity Citrus bergamia Risso et Poiteau (bergamot) essential oil (BEO). Carrageenan-induced paw edema rats was used an experimental model inflammation. Because toxicity furocoumarins, we performed our study by using BEO fraction deprived these compounds (BEO-FF). Treatment with BEO-FF a significant inhibition induced sub-plantar injection carrageenan....
Introduction: Cannabidiol (CBD) is an active chemical contained in the plant Cannabis sativa . It a resorcinol-based compound that crosses blood-brain barrier without causing euphoric effects. CBD has plethora of pharmacological effects therapeutic interest. been authorized European Union as anticonvulsant against serious infantile epileptic syndromes, but its safety profile still not sufficiently described. Methods: With goal expanding information on use antiepileptic agent beyond most...
Botanical products sold in the health area are generally intended as drugs, medicinal products, food supplements or substances for therapeutic use. Use of botanicals improving to care human has evolved independently different countries worldwide. Regulatory issues regarding botanical designed market and their influence on research development discussed. European Union (EU) United States (US) policies regulating these focused with comments legislations delivered during last ten years...
Introduction: Gradual population aging is creating a new set of needs in the general population. Memory capacity decreases with age, and memory deficits are considered an early symptom Alzheimer's Disease (AD), one most prevalent cognitive disorders older people. Numerous studies have shown that grape polyphenolic compounds (GPs) able to attenuate impairment reduce brain lesions experimental AD animal models. These GP effects associated improvement antioxidant status prevention free...
Risankizumab is a selective, humanized immunoglobulin G1 (IgG1) monoclonal anti-body directed against interleukin (IL)-23 protein. The therapeutic indication of risankizumab moderate-to-severe plaque psoriasis and psoriatic arthritis. safety profile currently defined by data obtained with clinical trials used for the authorization entry into market. aim this study was to expand information on through descriptive post-marketing analysis real-world regarding serious adverse reactions (SARs)...
Dry eye disease (DED) is a common condition causing substantial burden. A randomized, controlled, single-masked study was performed in 40 patients with mild to moderate DED evaluate the efficacy and safety of collyrium based on crosslinked hyaluronic acid (XLHA) coenzyme Q10 (CoQ10).Enrolled subjects were divided into 2 groups: group A, treated XLHA + CoQ10; B, (HA). Eyedrops administered 4 times daily for 3 months. The Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time...
This study evaluates salivary immunoglobulin A (s-IgA) and interleukin 6 (IL-6) in saliva of children its correlation to tooth decay severity. Fifty-nine patients were divided into two groups: caries free (A group) active (B group). B group was investigated according Mount Monse indices. Mean IgA rate between groups 16.7 ± 4.5 mg/dL vs. 21.8 12.9 mg/dL) not significant, while IL-6 19.02 5.3 pg/mL 30.2 11.8 pg/mL) statistically different. revealed that levels significantly higher with when...
Background/ Objective: Major depressive disorder (MDD) is a common mental disorder, with significant part of patients developing treatment-resistant depression (TRD). Esketamine an antagonist the N-methyl-D-aspartate receptor indicated as nasal spray in combination other antidepressants for adults TRD. Signals suspected adverse reactions (SARs) to esketamine from EudraVigilance database European countries were analyzed more defined safety profile this drug real-world. Methods: SARs reported...