A5101952965- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Renal function and acid-base balance
- Advanced MRI Techniques and Applications
- Renal cell carcinoma treatment
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Head and Neck Cancer Studies
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Enhanced Recovery After Surgery
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Trauma and Emergency Care Studies
- Disaster Response and Management
- Medical Imaging Techniques and Applications
- Viral-associated cancers and disorders
- Cardiac Arrest and Resuscitation
- Non-Invasive Vital Sign Monitoring
- CNS Lymphoma Diagnosis and Treatment
- Anesthesia and Pain Management
- Ultrasound in Clinical Applications
Louisiana State University
2025
University of Sheffield
2025
University College London
1995-2023
Royal London Hospital
2001-2023
The Alfred Hospital
2007-2023
Leiden University
2021
Missouri University of Science and Technology
2020
Yale New Haven Hospital
2018
Royal Sussex County Hospital
2008-2017
University Hospital Southampton NHS Foundation Trust
2013-2016
PURPOSE We report the results of a prospectively randomized study that compared combination epirubicin, cisplatin, and protracted venous infusion fluorouracil (5-FU) (ECF regimen) with standard 5-FU, doxorubicin, methotrexate (FAMTX) in previously untreated patients advanced esophagogastric cancer. PATIENTS AND METHODS Two hundred seventy-four adenocarcinoma or undifferentiated carcinoma were analyzed for survival, tumor response, toxicity, quality life (QL). RESULTS The overall response...
<h3>Objective:</h3> To test the hypothesis that perioperative plasma volume expansion would preserve gut mucosal perfusion during elective cardiac surgery. <h3>Design:</h3> Prospective randomized open study. <h3>Setting:</h3> Teaching hospital. <h3>Patients:</h3> Sixty American Society of Anesthesiology grade III patients with a preoperative left ventricular ejection fraction 50% or greater undergoing <h3>Interventions:</h3> Patients were allocated randomly to control protocol group. The...
PURPOSE: To evaluate the pharmacokinetics and toxicity of an antisense oligonucleotide targeting bcl-2 in patients with non-Hodgkin’s lymphoma (NHL) to determine efficacy using clinical biologic end points. PATIENTS AND METHODS: Twenty-one Bcl-2–positive relapsed NHL received a 14-day subcutaneous infusion G3139, 18-mer phosphorothioate complementary first six codons open reading frame. Plasma were measured by anion exchange high-performance liquid chromatography. Response was assessed...
Human papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC) is associated with improved survival compared HPV-negative disease. However, a minority of HPV-positive patients have poor prognosis. Currently, there no generally accepted strategy for identifying these patients. We retrospectively analysed 270 consecutively treated OPSCC from three centres effects clinical, pathological, immunological, and molecular features on disease mortality. used Cox regression to examine associations...
We report the final results of a prospectively randomized study that compared combination epirubicin, cisplatin and protracted venous infusion fluorouracil (5-FU) (ECF regimen) with standard 5-FU, doxorubicin methotrexate (FAMTX) in previously untreated patients advanced oesophagogastric cancer. Between 1992 1995, 274 adenocarcinoma or undifferentiated carcinoma were from eight oncology centres UK analysed for response survival. The overall rate was 46% (95% confidence interval (CI), 37–55%)...
A mechanical hand grip dynamometer was used to derive age- and sex-related standard strengths from 247 healthy volunteers between 16 95 yr old. Preoperative strength measured in 90 patients related postoperative complication rates. of 85% for age sex found be the most effective cut-off prediction complications terms sensitivity specificity, predicting 74% (p less than 0.05). Specificity is improved over previously published standards alone especially when assessing elderly patient (50% vs...
6 months of oxaliplatin-containing chemotherapy is usually given as adjuvant treatment for stage 3 colorectal cancer. We investigated whether would be non-inferior to the usual treatment.The SCOT study was an international, randomised, phase 3, non-inferiority trial done at 244 centres. Patients aged 18 years or older with high-risk II and III cancer underwent central randomisation minimisation centre, choice regimen, sex, disease site, N stage, T starting dose capecitabine. were assigned...
To confirm the consistent effects on Doppler-measured aortic blood flow velocity waveform variables of alterations in left ventricular preload, afterload, and inotropy using pharmacologic physiologic maneuvers.Medical school laboratory.Healthy volunteers.Increasing infusion rates dobutamine (1.25 to 5 micrograms/kg.min), esmolol mg/min), phentolamine methoxamine metaraminol placebo mL 0.9% saline/min) increasing plasma removal (0.5 1 L) awake, rested, supine subjects.Ascending was measured...
The treatment of patients with diffuse large B-cell lymphoma (DLBCL) cardiac comorbidity is problematic, because this group may not be able to receive anthracycline-containing chemoimmunotherapy. We designed a single-arm phase II multicenter trial rituximab, gemcitabine, cyclophosphamide, vincristine, and prednisolone (R-GCVP) in considered unfit for chemoimmunotherapy comorbidity.
Introduction Scope and purpose Methodology Guideline development process Patient involvement GRADE Good practice points Dissemination implementation updates date of next review Summary Key recommendations References Recommendaations/good auditable outcomes Kaposi sarcoma (KS) Diagnosis, staging prognosis Management Prevention Local therapy Radiotherapy Other local therapies Systemic HAART Cytotoxic chemotherapy Liposomal anthracyclines Taxanes Immunotherapy systemic AIDS-related non-Hodgkin...
Abstract Objectives Transfusion of a high ratio plasma to packed red blood cells (PRBCs), treat or prevent acute traumatic coagulopathy, has been associated with survival after major trauma. However, the effect prehospital on patient outcomes inconsistent. The aim this pilot trial was assess feasibility transfusing freeze‐dried (RBCs) using randomized controlled design in an Australian aeromedical setting. Methods Patients attended by helicopter emergency medical service (HEMS) paramedics...
Carcinoma of the pancreas is an aggressive tumour with extremely poor prognosis. Recent studies have shown that chemotherapy can improve survival as well quality life. Since prognosis generally poor, identification early responders to important avoid unnecessary toxicity in patients who are not responding. Response assessment by conventional radiographic methods problematical because treatment induces fibrosis and makes measurements difficult. The aim this pilot study was assess...
This retrospective analysis aimed to identify whether breast cancer patients receiving radiotherapy alone following a complete clinical remission (cCR) neoadjuvant chemotherapy had worse outcome than those treated with surgery.One hundred thirty-six who achieved cCR for early were identified from prospectively maintained database of 453 patients. Of these, 67 undergone surgery as their primary locoregional therapy, and 69 alone. Outcome was assessed in relation local recurrence-free...
To compare the outcome of patients diagnosed with HIV infection and diffuse large B-cell lymphoma (DLBCL) treated R-CHOP in cART era that a HIV-negative control group.From 2003 to 2011, 305 (97 HIV-positive) were DLBCL R-CHOP. Clinical features compared using chi-square or Fisher's exact test. Survival analysis was performed Kaplan-Meier method log-rank Multivariate Cox regression proportional hazards model.HIV-positive had more B symptoms extranodal sites disease at diagnosis, but...
Oropharyngeal squamous cell carcinoma (SCC) is staged using the TNM system. Human papillomavirus (HPV)-positive tumors have improved prognosis, despite presenting at advanced stage. Optimal treatment and stratification of HPV-positive patients are not clearly defined.We retrospectively analyzed 266 with oropharyngeal SCC for mortality feeding tube dependency related to stage, HPV status, treatment.TNM staging was prognostic in HPV-negative (stage III/IV hazard ratio [HR], 2.00; p = .05; N(+)...