A5006287411- Cytomegalovirus and herpesvirus research
- Neuroinflammation and Neurodegeneration Mechanisms
- Influenza Virus Research Studies
- Connexins and lens biology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Animal Disease Management and Epidemiology
- Tryptophan and brain disorders
- Immune Response and Inflammation
- PARP inhibition in cancer therapy
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Respiratory viral infections research
- DNA Repair Mechanisms
- Herpesvirus Infections and Treatments
- Cell death mechanisms and regulation
- Retinal Development and Disorders
Centro de Biología Molecular Severo Ochoa
2017-2021
Universidad Autónoma de Madrid
2017-2021
Universidad Iberoamericana
2015
The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number function. Mice bearing specific deficiency PARP-1-deficient background showed defective thymocyte maturation diminished numbers peripheral CD4+ CD8+ T-cells. Meanwhile, was not affected single PARP-1 or PARP-2-deficient mice. lymphopenia associated with dampened vivo immune responses to synthetic...
Although considered a rare retinal dystrophy, retinitis pigmentosa (RP) is the primary cause of hereditary blindness. Given its diverse genetic etiology (>3000 mutations in >60 genes), there an urgent need for novel treatments that target common features disease. TLR2 key activator innate immune response. To examine role RP progression we characterized expression profile Tlr2 and adaptor molecules consequences deletion two genetically distinct models RP: Pde6brd10/rd10 (rd10) RhoP23H/+...
In this study we demonstrated that the vaccine candidate against avian influenza virus H5N1 based on hemagglutinin H5 (HA) fused to chicken CD154 (HACD) can also be used for differentiating infected from vaccinated animals (DIVA). As strategy of DIVA requires at least two proteins, obtained a variant nucleoprotein (NP49-375) in E. coli. After its purification by IMAC, competence proteins NP49-375 and HACD as coating antigens indirect ELISA assays were tested using sera chickens immunized...