A5015447860- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Blood transfusion and management
- Cardiac Arrest and Resuscitation
- Vascular Procedures and Complications
- Trauma Management and Diagnosis
- Abdominal vascular conditions and treatments
- Liver Disease and Transplantation
- Appendicitis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Peripheral Artery Disease Management
- Intestinal and Peritoneal Adhesions
- Cardiac, Anesthesia and Surgical Outcomes
- Pericarditis and Cardiac Tamponade
- Cardiac Structural Anomalies and Repair
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Gallbladder and Bile Duct Disorders
- Trauma and Emergency Care Studies
- Intensive Care Unit Cognitive Disorders
- Vascular anomalies and interventions
Washington University in St. Louis
2024-2025
ORCID
2024
University of Pennsylvania
2022-2024
Dartmouth Hospital
2024
Dartmouth Health
2024
Hartford Hospital
2023
Rutgers, The State University of New Jersey
2023
Emory University
2023
Salem Hospital
2023
Florida College
2023
Tranexamic acid (TXA) given early, but not late, after traumatic brain injury (TBI) appears to improve survival. This may be partly related TXA-driven profibrinolysis and increased leukocyte (LEU)-mediated inflammation when administered late post-injury. We hypothesized that early TXA (1 hour post-TBI), blunts penumbral, blood-brain barrier (BBB) leukocyte-endothelial cell (LEU-EC) interactions microvascular permeability, in vivo compared with administration (24 hours post-TBI).CD1 male mice...
Introduction Venous thromboembolism (VTE) causes significant morbidity in patients with trauma despite advances pharmacologic therapy. Prior literature suggests standard enoxaparin dosing may not achieve target prophylactic anti-Xa levels. We hypothesize that a new weight-based protocol monitoring for dose titration critically injured is safe and easily implemented. Methods This prospective observational study included admitted to the intensive care unit (ICU) from January 2021 September...
BACKGROUND Serial neurological examinations (NEs) are routinely recommended in the intensive care unit (ICU) within first 24 hours following a traumatic brain injury (TBI). There currently no widely accepted guidelines for frequency of NEs. Disruptions to sleep-wake cycles increase delirium rate. We aimed evaluate whether there is correlation between prolonged hourly (Q1)-NE and development determine if this practice reduces likelihood missing detection process requiring emergent...
Completion angiography (CA) is commonly used following repair of extremity vascular injury and recommended by the Eastern Association for Surgery Trauma practice management guidelines trauma. However, it remains unclear which patients benefit from CA because only level 3 evidence exists.This prospective observational multicenter (18LI, 2LII) analysis included 15 years or older with injuries requiring operative management. Clinical variables outcomes were analyzed respect to our primary study...
Hemorrhagic pericardial effusion (HPE) is a rare but life-threatening diagnosis that may occur after thoracic trauma. Previous reports have concentrated on delayed HPE in those who did not require initial surgical intervention for their traumatic injuries. In this report, we identify and characterize the phenomenon of emergent surgery trauma.This retrospective review patients required trauma at level 1 center from 2017 to 2021. Using institutional database, demographics, injury...
Abstract Background . Early post-TBI Tranexamic acid (TXA) may reduce blood-brain-barrier (BBB) permeability, but it is unclear if this effect fixed regardless of dose. We hypothesized that TXA demonstrates a dose dependent reduction in vivo penumbral leukocyte (LEU) mobilization, BBB microvascular and enhanced neuroclinical recovery. Study Design. CD1 male mice (n=40) were randomized to TBI by controlled cortical impact (Injury, I) or sham craniotomy (S), followed IV bolus either saline...