A5029610249- Protease and Inhibitor Mechanisms
- Signaling Pathways in Disease
- Connexins and lens biology
- Aluminum toxicity and tolerance in plants and animals
- Wnt/β-catenin signaling in development and cancer
- Connective tissue disorders research
- Heavy Metal Exposure and Toxicity
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
- Adipose Tissue and Metabolism
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Acute Myocardial Infarction Research
- Immunotoxicology and immune responses
- Retinal Development and Disorders
- Cell Adhesion Molecules Research
- Physiological and biochemical adaptations
University of Pennsylvania
2024
Lehigh University
2018-2020
West Virginia University
2015
University of Calcutta
2012
Members of the disintegrin metalloproteinase (ADAM) family have important functions in regulating cell-cell and cell-matrix interactions as well cell signaling. There are two major types ADAMs: somatic ADAMs (sADAMs) that a significant presence tissues, testicular (tADAMs) expressed predominantly testis. Genes encoding tADAMs can be further divided into groups: group I (intronless) II (intron-containing). To date, tAdams only been reported placental mammals, their evolutionary origin...
The gap junction protein Connexin 43 (Cx43) contributes to cell fate decisions that determine the location of fin ray joints during regeneration. Here, we provide insights into how Cx43, expressed medially, influences changes in gene expression lateral skeletal precursor cells. Using Gap27 peptide inhibitor specific show Cx43-gap junctional intercellular communication (GJIC) Cx43-dependent phenotypes, including segment length. We also demonstrate Cx43-GJIC Smp/β-catenin pathway cells, and...
The correct positioning of joints in the vertebrate skeleton is not well understood. Mutations connexin43 (cx43) cause short segment phenotype zebrafish fin (sofb123 ) mutant. We have shown that Cx43 suppresses evx1 expression, a transcription factor required for joint formation. Here, we provide novel insights into how influences transcription. First, find Simplet (Smp) knockdown recapitulates sofb123 phenotypes reduced regenerate length and length, evidence synergy between cx43 smp...
The distinct anatomic environment in which adipose tissues arise during organogenesis is a principle determinant of their adult expansion capacity. Metabolic disease results from deficiency hyperplastic within the dermal/subcutaneous depot; thus, understanding embryonic origins dermal imperative. Using single-cell transcriptomics throughout murine embryogenesis, we characterized cell populations, including Bcl11b + cells, that regulate development white tissue (dWAT). We discovered BCL11b...
Abstract Lipid nanoparticles (LNPs) have been shown to be a safe and potent platform for vaccine delivery. When added subunit proteins, they the potential induce strong immune responses capable of generating long-lasting immunity. Merck has developed variety LNPs utilizing different cationic lipid components including LNP A, which long half-life in vivo, B, shorter vivo is more biodegradable. Protein vaccines containing A generate robust antigen-specific humoral cellular with some dose...