A5020388402- Polyomavirus and related diseases
- Antenna Design and Analysis
- Full-Duplex Wireless Communications
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Fibroblast Growth Factor Research
- Nonmelanoma Skin Cancer Studies
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Effects of Radiation Exposure
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Cancer and Skin Lesions
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Breast Lesions and Carcinomas
- Cutaneous Melanoma Detection and Management
- Hedgehog Signaling Pathway Studies
- Tracheal and airway disorders
Rabin Medical Center
2015-2025
Tel Aviv University
2014-2023
Arthur M. Sackler Gallery
2020
Hadassah Medical Center
2008
Weizmann Institute of Science
2008
Sheba Medical Center
2006
Wolfson Medical Center
2006
Kaplan Medical Center
2000-2006
Assaf Harofeh Medical Center
2002
Mazor Mental Health Center
1999
Avelumab, a human anti-programmed death-ligand 1 immunoglobulin G1 monoclonal antibody, showed favorable efficacy and safety in patients with metastatic Merkel cell carcinoma (mMCC) the phase II JAVELIN 200 trial, leading to approval multiple countries. We describe real-world experience avelumab mMCC from an expanded access program.Eligible had progressive disease during or after chemotherapy were ineligible for clinical trial participation. Patients received initial 3-month supply of...
Merkel cell carcinoma is a rare and highly aggressive skin tumor. The purpose of this study was to determine the role radiation therapy chemotherapy in treatment patients with carcinoma.A retrospective analysis 27 treated at Rabin Medical Center Israel presented, focusing on details. Data for 40 (the authors' an additional 13 from Israeli Cancer Registry), were analyzed prognostic factors using univariate multivariate analyses.Univariate analyses revealed regional lymph node involvement...
The role of local excision in patients with good histological response to neoadjuvant chemoradiation for locally advanced rectal cancer is unclear, mainly because possible regional nodal involvement. This study aims evaluate the correlation between pathological T and N stages following outcome mural complete undergoing excision.This investigation was conducted as a retrospective analysis. Between January 1997 December 2007, 320 T3 4Nx, TxN+ or distal (≤ 6 cm from anus) T2N0 underwent...
Abstract Background Merkel cell carcinoma (MCC) is a rare and aggressive malignancy of the skin, affecting predominantly fair‐skinned older population exposed to high levels ultraviolet light. Immune suppression considered significant risk factor. With recent advances in field immunotherapy, treatment paradigm for advanced MCC, traditionally based on chemotherapy, has largely shifted anti‐PD‐L1 PD‐1 agents such as avelumab pembrolizumab, respectively. However, real‐world data remain sparse....
BACKGROUND Merkel cell carcinoma (MCC) has been associated with a high incidence of other skin tumors and hematological malignancies. The purpose this study was to analyze data from the Israel Cancer Registry regarding second neoplasms in patients MCC their impact on survival. METHODS Sixty-seven whom diagnosed between 1983 1999 were included. Data collected age, gender ethnic origin, dates diagnosis any neoplasm, date cause death, if applicable. Comparison MCC-specific survival, estimated...
Imatinib mesylate (IM) is a tyrosine kinase inhibitor, which inhibits phosphorylation of downstream proteins involved in BCR-ABL signal transduction. It has proved beneficial treating patients with chronic myeloid leukaemia (CML). In addition, IM demonstrates activity against malignant cells expressing c-kit and platelet-derived growth factor receptor (PDGF-R). The the blastic crisis CML various myeloma cell lines suggests that this drug may also target other cellular components. light...
Background: The role of adding chemotherapy to adjuvant radiation therapy in resectable Merkel cell carcinoma (MCC) remains controversial. Previous studies have shown conflicting results, and long-term outcome data are limited. Objectives: In this study, we aimed evaluate the survival outcomes patients with MCC treated surgery followed by either alone or combined chemoradiation. Methods: This retrospective multicenter cohort study analyzed 105 between 1985 2023. Patients received (n = 53)...
Basic fibroblast growth factor (bFGF) is a mitogen and survival in fibroblasts endothelial cells. It acts as an angiogenesis breast cancer, but paradoxically inhibits proliferation several cancer cell lines. In this study, we investigated the effects of bFGF on MCF-7 human cells order to determine if these were also opposite those fibroblasts. Incubation NIH 3T3 with for 24 h caused approximately 30% increase day 12 +/- 2 adherent colonies while causing 50% decrease colony formation. prior...
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin that associated with a high incidence recurrence and metastasis. The therapeutic arsenal for this malignancy limited once it spreads, there no effective treatment. c-kit expression has been demonstrated previously in primary MCCs thus raising possibility treating imatinib mesylate, tyrosine kinase inhibitor shown promise management expressing tumors. In study we examine 25 additional also 6 their lymph node...
A free-floating cell line has been established from a metastatic lesion of Merkel carcinoma (MCC) patient. The was characterized by immunocytochemical reactions with antibodies against the epithelial and neuroendocrine antigens: cytokeratin 20, neuron-specific enolase, chromogranin A, neurofilament protein, synaptophysin, calcitonin. Karyotype analysis MCC cells showed deletion in chromosomes 3 7, loss chromosome 10, several translocations other chromosomes. No mutation detected TP53 gene,...
Classical Kaposi's sarcoma (CKS) is a rare indolent proliferative disease which particularly prevalent among Jews of Ashkenazi and Mediterranean origin. To define guidelines for its comprehensive management, we conducted retrospective analysis 123 patients, focusing mainly on treatment modalities. The CKS-related mortality was 4% (5 patients). Of the 39 patients whom observation only primary approach, 15 (38%) remained progression-free 1-83 months (median, 4 months). Twenty-nine 52 (56%) who...