A5038907105- Frailty in Older Adults
- Nutrition and Health in Aging
- Geriatric Care and Nursing Homes
- Chronic Disease Management Strategies
- Health disparities and outcomes
- Dementia and Cognitive Impairment Research
- Dental Health and Care Utilization
- Dysphagia Assessment and Management
- Body Composition Measurement Techniques
- Palliative Care and End-of-Life Issues
- Antioxidant Activity and Oxidative Stress
- Parathyroid Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Disease Prevention
- Hip and Femur Fractures
- Sirtuins and Resveratrol in Medicine
- Nutritional Studies and Diet
- Balance, Gait, and Falls Prevention
- Cardiovascular Disease and Adiposity
- Health and Wellbeing Research
- Global Health Care Issues
- Intergenerational Family Dynamics and Caregiving
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Hormonal and reproductive studies
The University of Tokyo
2016-2025
Tokyo Metropolitan Institute of Gerontology
2016-2025
Futaba (Japan)
2024
Institute for Future Engineering
2020-2024
Tokyo Institute of Technology
2021
Osaka University
2019-2021
Kobe University
2012-2017
Shonan Oiso Hospital
2017
University of Tokyo Hospital
2000-2012
D.F. Chebotarev Institute of Gerontology
2012
Oral health is important for maintaining general among the elderly. However, a longitudinal association between poor oral and has not been reported. We investigated whether status can predict physical weakening (physical frailty, sarcopenia, subsequent disability) identified impact of accumulated (i.e. frailty) on adverse outcomes, including mortality. A total 2,011 elderly individuals (aged ≥ 65 years) participated in baseline survey Kashiwa study 2012. At baseline, 16 measures covariates...
Aim To develop a simple screening test to identify older adults at high risk for sarcopenia. Methods We studied 1971 functionally independent, community‐dwelling aged 65 years or randomly selected from the resident register of K ashiwa city, C hiba, J apan. Data collection was carried out between S eptember and N ovember 2012. Sarcopenia defined based on low muscle mass measured by bioimpedance analysis either strength characterized handgrip physical performance slow gait speed. Results The...
To enable easy assessment of oral frailty; that is, an overlapping slight decline in multifaceted function, any setting, we developed the frailty five-item checklist (OF-5), and examined its predictive validity for increased risks physical frailty, disability mortality among community-dwelling older adults.
Aim This cross‐sectional study had two aims: to assess the prevalence of oral frailty (OF), according Oral Frailty 5‐Item Checklist (OF‐5), among community‐dwelling older adults; and examine associations frailty, dietary variety, social engagement, physical frailty. Methods We pooled data from population‐based studies (the Otassha Study Itabashi Longitudinal on Aging). With OF‐5, OF is characterized by presence or more following: (i) fewer teeth, (ii) difficulty in chewing, (iii) swallowing,...
Cilostazol, a selective inhibitor of PDE3, has protective effect on endothelium after ischemic vascular damage, through production nitric oxide (NO). The purpose the present study was to clarify molecular mechanisms underlying preventive treatment with cilostazol oxidative stress-induced premature senescence in human endothelial cells.Prematurely senescent umbilical vein cells (HUVECs) were induced by hydrogen peroxide (H(2)O(2)) as judged senescence-associated beta-galactosidase assay...
To investigate the predictors of falls, such as comorbidity and medication, in geriatric outpatients a longitudinal observational study.A total 172 (45 men 126 women, mean age 76.9 ± 7.0 years) were evaluated. Physical examination, clinical history medication profile obtained from each patient at baseline. These patients followed for up to 2 years falls self-reported their physicians. The factors associated with analyzed statistically.A 32 experienced within years. On univariate analysis,...
Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) have pleiotropic vascular protective effects besides cholesterol lowering. Recently, experimental and clinical studies indicated that senescence of endothelial cells is involved in dysfunction atherogenesis. Therefore, the present study was performed to determine whether statins would reduce clarify molecular mechanisms underlying antisenescent property statins.Senescent human umbilical vein were induced by hydrogen...
Vascular calcification is clinically important in the development of cardiovascular disease. It reported that hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) inhibited vascular several clinical trials. However, mechanism poorly understood. Recently, it has been suggested apoptosis one processes regulating smooth muscle cell (VSMC) calcification. In this study, we investigated effect statins on VSMC by testing their apoptosis, focusing particular regulation...
Objective— Arterial calcification is associated with cardiovascular disease as a complication of advanced atherosclerosis. Aged vascular cells manifest some morphological features senescent phenotype. Recent studies have demonstrated that mammalian sirtuin 1 (SIRT1), histone deacetylase, an exciting target for management. Here, we investigated the role SIRT1 in model smooth muscle (SMCs). Methods and Results— In adenine-induced renal failure rats hyperphosphatemia, massive was induced aortic...
Background As Japan's population continues to age, it is estimated that the number of people aged ≥75 years will exceed 20 million by 2025. Furthermore, over past 10 years, we have not reduced difference between life expectancy and healthy expectancy. Therefore, extension development a society are most urgent issues. In terms medical care, changing times inevitably led changes in disease structures demands; therefore, delivery system has had be changed meet these demands. dementia rapidly...
Dementia and frailty often accompany one another in older age, requiring complex care resources. Available projections provide little information on their joint impact future health-care need from different segments of society the associated costs. Using a newly developed microsimulation model, we forecast this situation Japan as its population ages decreases size.In modelling study, built model that simulates an individual's status transition across 11 chronic diseases (including diabetes,...
Asymmetric NG,NG-dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide (NO) synthase and its plasma concentration elevated in patients with cardiovascular risk factors, including hyperlipidemia, hypertension, diabetes, hyperhomocysteinemia. Obstructive sleep apnea syndrome (OSAS) has been attracting attention as a factor for disorders because it often accompanies obesity, glucose impairment, dyslipidemia, all which are factors metabolic disease.In the present study,...
Abstract —Endothelial dysfunction has been reported to be the initial step in atherosclerosis. A noninvasive technique that uses ultrasound measure intima-media thickness of carotid artery applied evaluate localized This study was undertaken elucidate whether endothelial brachial is related artery. Thirty-four men with atherosclerosis (mean±SE age 61±2 years) and 33 age-matched without clinical were examined. The plaque formation common assessed by B-mode ultrasonography. We also...