A5054595884- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cardiac pacing and defibrillation studies
- Metal and Thin Film Mechanics
- Smart Materials for Construction
- Analytical Chemistry and Sensors
- Cardiovascular Syncope and Autonomic Disorders
- Gas Sensing Nanomaterials and Sensors
- ECG Monitoring and Analysis
- Acute Lymphoblastic Leukemia research
- Muscle activation and electromyography studies
- Multiple Myeloma Research and Treatments
- Cardiac Arrhythmias and Treatments
- EEG and Brain-Computer Interfaces
- Polyomavirus and related diseases
- Neuroscience and Neural Engineering
- Family and Patient Care in Intensive Care Units
- Anesthesia and Sedative Agents
- Treatment of Major Depression
- Advanced Sensor and Energy Harvesting Materials
- Palliative Care and End-of-Life Issues
- Neurological disorders and treatments
- Acoustic Wave Resonator Technologies
- Heart Rate Variability and Autonomic Control
- Cancer Genomics and Diagnostics
Manchester Academic Health Science Centre
2024
University of Manchester
2022-2024
University of Newcastle Australia
2022
Newcastle University
2022
University of Edinburgh
2021
Ludwig-Maximilians-Universität München
2010-2017
Munich Leukemia Laboratory (Germany)
2017
Leipzig University
2010
Malteser Waldkrankenhaus Erlangen
1978-2005
Universitätsklinikum Erlangen
1997
Monitoring minimal residual disease is an important way to identify patients with acute myeloid leukemia at high risk of relapse. In this study we investigated the prognostic potential monitoring by quantitative real-time polymerase chain reaction analysis NPM1 mutations in treated AMLCG 1999, 2004 and 2008 trials. Minimal was monitored - aplasia, after induction therapy, consolidation during follow-up 588 samples from 158 positive for A, B D (with a sensitivity 10−6). One hundred...
Midazolam was applied transmucosally in 47 children randomly assigned to three different groups. Group N received 0.2 mg·kg −1 nasally, group R 0.5 rectally, and S sublingually. All groups were treated 60 min prior a planned i.v. puncture with EMLA ® . Reliable valid psychological parameters (such as emotional situation, shivering, awareness, respiratory rate facial colour) scored after premedication before puncture, 20 until induction. A blood sample drawn 10, 30 the levels of midazolam,...
High quality primary care is a foundational element of effective health services. Internationally, physicians (general practitioners (GPs), family doctors) are experiencing significant workload pressures. How non-patient-facing work contributes to these pressures and what constitutes this poorly understood often unrecognised undervalued by patients, policy makers, even clinicians engaged in it. This paper examines ethnographically, informed practice theory, the Listening Guide, empirical...
We describe an analytical procedure for the simultaneous quantification of citalopram (seropram), clozapine (leponex), fluoxetine (fluctine), norfluoxetine, maprotiline (ludiomil), desmethylmaprotiline and trazodone (trittico) in human serum within a period 11.5 minutes using reversed phase HPLC. After 2 liquid/liquid extractions sample preparation phase, drugs metabolites were separated on C18 column mobile consisting acetonitrile/buffer (30/70, v:v) at 70 degrees C, flow rate 1.5 m/min...
We report the clinical features and treatment outcome of 33 patients with multiple sclerosis who developed acute promyelocytic leukemia. Thirty were previously exposed to mitoxantrone. The median latency period between initiation leukemia diagnosis was 32 months. PML-RARA bcr1 iso-form identified in 87% cases. Twenty-nine (90%) achieved hematologic remission after all-trans retinoic acid chemotherapy (n=31) or arsenic trioxide acid. Consolidation included modified trioxide. At a follow up 26...
Some patients with acute myeloid leukemia (AML) who are in complete remission after induction chemotherapy harbor persisting pre-leukemic clones, carrying a subset of leukemia-associated somatic mutations. There is conflicting evidence on the prognostic relevance these clones for AML relapse. Here, we characterized paired pre-treatment and samples from 126 mutations 68 genes. Fifty (40%) retained ⩾1 mutation during at variant allele frequency ⩾2%. Mutation persistence was most frequent...
Article Titannitrid-Herzschrittmacher-Elektroden - Pacemaker Electrodes Made of Titanium Nitride was published on January 1, 1989 in the journal Biomedical Engineering / Biomedizinische Technik (volume 34, issue 7-8).
Global health development projects are inherently governed by bounded, temporal and linear time frames: the initiation, implementation ending of time-limited interventions. This projectification global programmes has wide-reaching consequences as projects, often unsustainable produces both new life possibilities uncertain futures. article highlights effects agenda on primary system rebuilding efforts in Sierra Leone. Attention is paid to how public affected healthcare management a district...
Abstract This paper describes measurements of the dielectric constant and conductivity on pure doped ice single crystals subjected to hydrostatic pressure. The dopants used were NH 3 ( c NH3 ≈ 5 × 10 -5 1.2 -4 mol/1) or HF = -6 mol/1). pressure temperature ranges covered 1 500 bar — 15 60 ° C. activation volumes for orientational ionic contribution could be determined. A definitive interpretation is not possible because many questions concerning formation defects are still open, hi addition...
Progress in electrostimulation has to be expected the threshold and detection performance. Toward this goal a low interface impedance under long term conditions as well high biocompatibility of electrode material are most essential requirements. In following is discussed from physical point view. It demonstrated that important features good design active surface area equilibrium thickness dielectric constant oxide layer (if any). Based on these requirements several new designs have been...
COVID-19 brought additional challenges to Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) decision-making, which was already a contentious issue. In the UK, reports of poor DNACPR decision-making and communication emerged in 2020, including from regulator, Care Quality Commission. This paper explores experiences people who discussed with healthcare professional on behalf relative during coronavirus pandemic, aim identifying areas good practice what needs be improved.a total 39...
An activity sensing rate-responsive pacing system is presented which adaptively controls heart rate to adjust cardiac output in response increased metabolic demand, and more optimally restore homeostasis of the intact cardiovascular system. The current use ventricular demand DDD universal systems, although multi-parameter multi-function programmable, are fixed at these programmed settings. These devices adequate for patients rest or during moderate exertion, but suboptimal physically active...
Unipolar pacemaker leads with titanium nitride or iridium coated tips having the same fractal surface structure have been examined in regard to their stimulation and sensing performance. It is shown, that electrochemical active area most important factor, type of material less important. Tip coatings show highest therefore best results comparison smoother material.
Abstract This paper describes measurements of the dielectric constant and conductivity on pure doped ice single crystals subjected to hydrostatic pressure. The dopants used were NH 3 ( c NH3 ≈ 5 × 10 -5 1.2 -4 mol/1) or HF = -6 mol/1). pressure temperature ranges covered 1 500 bar — 15 60 ° C. activation volumes for orientational ionic contribution could be determined. A definitive interpretation is not possible because many questions concerning formation defects are still open, hi addition...
Article LANGZEITSTABILITÄT DES DETEKTIONS- UND REIZSCHWELLENVERHALTENS VON TITANNITRID - HERZSCHRITTMACHER ELEKTRODEN was published on January 1, 1990 in the journal Biomedical Engineering / Biomedizinische Technik (volume 35, issue s3).