A5047110309- Urinary Bladder and Prostate Research
- Spinal Cord Injury Research
- Pelvic floor disorders treatments
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
- Tissue Engineering and Regenerative Medicine
- EEG and Brain-Computer Interfaces
- Neuroscience of respiration and sleep
- Anesthesia and Sedative Agents
- Clinical Nutrition and Gastroenterology
- Spinal Dysraphism and Malformations
- Non-Invasive Vital Sign Monitoring
- Nerve Injury and Rehabilitation
- Autism Spectrum Disorder Research
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Molecular Communication and Nanonetworks
- Wireless Body Area Networks
- Phonocardiography and Auscultation Techniques
- Pancreatitis Pathology and Treatment
- Infant Nutrition and Health
- Organ and Tissue Transplantation Research
Louis Stokes Cleveland VA Medical Center
2014-2024
MetroHealth
2017-2024
MetroHealth Medical Center
2017-2023
Cleveland Clinic Lerner College of Medicine
2020-2023
Cleveland FES Center
2014-2023
Cleveland Clinic
2020
Case Western Reserve University
2014-2019
University School
2017
Ohio University
2017
Rehabilitation Research and Development Service
2017
Objective. The dorsal root ganglion is an attractive target for implanting neural electrode arrays that restore sensory function or provide therapy via stimulation. However, penetrating microelectrodes designed these applications are small and deliver low currents. For long-term performance of microstimulation devices, novel coating materials needed in part to decrease impedance values at the electrode-tissue interface increase charge storage capacity. Approach. Conductive polymer...
The aim of this study was to evaluate the long-term effect localized growth factor delivery on sciatic nerve regeneration in a critical-size (>1 cm) peripheral defect. Previous work has demonstrated that bioactive proteins can be encapsulated within double-walled, poly(lactic-co-glycolic acid)/poly(lactide) microspheres and embedded walls biodegradable polymer guides composed poly(caprolactone). Within study, containing glial cell line-derived neurotrophic (GDNF) were used bridge 1.5-cm...
Diagnosis of lower urinary tract dysfunction with urodynamics has historically relied on data acquired from multiple sensors using nonphysiologically fast cystometric filling. In addition, state-of-the-art neuromodulation approaches to restore bladder function could benefit a sensor for closed-loop control, but practical and automated analysis are not available. We have developed an algorithm real-time event detection based single in situ sensor, making it attractive both extended ambulatory...
Primary afferent microstimulation has been proposed as a method for activating cutaneous and muscle fibers to restore tactile proprioceptive feedback after limb loss or peripheral neuropathy. Large populations of primary can be accessed directly by implanting microelectrode arrays in the dorsal root ganglia (DRG), which provide compact stable target stimulating diverse group sensory fibers. To gain insight into factors affecting number types afferents activated, we developed computational...
Continuous monitoring of bladder activity during normal daily activities would improve clinical diagnostics and understanding the mechanisms underlying function, or help validate how differing neuromodulation strategies affect bladder. This work describes a urological monitor conscious (UroMOCA). The UroMOCA included pressure sensor, urine impedance-sensing electrodes, wireless battery recharge data transmission circuitry. Components were assembled on circuit board encapsulated with an...
Objective: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex contractions increase capacity. However, it unknown if GNS improve urinary continence or help meet individuals' management goals during sustained use, which required to be effective.Design: Subjects...
Vascularized composite allotransplantation has become a clinical reality. Patients undergoing vascularized have modest functional return. Most patients had multiple acute rejections. The effect of rejections influencing outcomes is unknown. This study systematically analyzes the effects on outcome.Rat orthotopic hind-limb transplants were performed from Brown-Norway to Lewis rats. Group 1 consisted isografts. In group 2, daily cyclosporine was administered prevent rejection. 3, recipients...
Background: Neurogenic detrusor overactivity after spinal cord injury (SCI) causes urinary incontinence and reduces bladder capacity. Surface electrical genital nerve stimulation (GNS) acutely inhibits reflex contractions. The amplitude selected for GNS is typically twice the that required to evoke pudendal-anal reflex. There concern about ability of persons with sensation comfortably tolerate effective levels GNS. objective this work determine if incomplete SCI are able acute...
Lower urinary tract dysfunctions, such as incontinence and overactive bladder, are conditions that greatly affect the quality of life for millions individuals worldwide. For those with more complex pathophysiologies, diagnosis these often requires a urodynamics study, providing physicians snapshot view bladder mechanics. Recent advancements in implantable pressure monitors advanced data analysis techniques have made through chronic monitoring promising prospect. However, implants targeted at...
Anonymous online survey OBJECTIVES: To investigate the priorities, needs and willingness to adopt nerve stimulation devices for managing neurogenic bladder bowel function in people with spinal cord injury (SCI) living Australia.
Lower urinary tract dysfunction (LUTD) is a debilitating condition that affects millions of individuals worldwide, greatly diminishing their quality life. The use wireless, catheter-free implantable devices for long-term ambulatory bladder monitoring, combined with single-sensor system capable detecting various events, has the potential to significantly enhance diagnosis and treatment LUTD. However, these systems produce large amounts data may contain physiological noise in pressure signals...
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality life. Neuromodulation lower urinary tract nerves can be used to treat sensations urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, conditional stimulation has been investigated as possible improvement state-of-the-art open-loop systems available today. However, this requires robust, adaptive, and...
Abstract Background The increasing use of prescription opioids has contributed to the epidemic opioid abuse in United States. Efforts reduce prescriptions and offer alternatives for pain management are needed. Objective To determine success a multidisciplinary project manage chronic while reducing reliance on population patients with spinal cord injury (SCI). Design Retrospective analysis. Setting This study was conducted an SCI system care northeast Ohio. Participants Individuals receiving...
Kinesthesia is the sense of limb movement. It fundamental to efficient motor control, yet its neurophysiological components remain poorly understood. The contributions primary muscle spindles and cutaneous afferents kinesthetic have been well studied; however, potential from sensory group responses that are different than not ruled out. Electrophysiological recordings in peripheral nerves brains male Sprague Dawley rats with a degloved forelimb preparation provide evidence rapidly adapting...
Individuals with spinal cord injury (SCI) usually develop neurogenic detrusor overactivity (NDO), resulting in bladder urgency and incontinence, reduced quality of life. Electrical stimulation the genital nerves (GNS) can inhibit uncontrolled contractions individuals SCI. An automated closed-loop neuromodulation system currently does not exist but could improve this approach. We have developed a custom algorithm to identify trigger from pressure data without need for abdominal measurement....
New research tools are essential to help understand the neural control of lower urinary tract (LUT). A more nuanced understanding neuroanatomy bladder function could enable new treatment options or neuroprosthesis eliminate incontinence. Here we describe design, prototyping and validation a sensing mechanism for catheter-free fluid volume estimating system chronic neurophysiological studies ambulatory urodynamics. The consists two stimulation electrodes, one anode, microcontroller recording....
The role of peripheral nerves in regulating major organ function health and disease is not well understood. Elucidating the relationships between biomarkers neural activity during conditions free form anesthesia essential to advancing future investigations autonomic control improving precision for neuromodulation treatment approaches. Here we present a simple, customizable, off-the-shelf component sensor platform meet research needs studying different organs under conscious, movement....