Yurae Shin
A5101509481- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Bacterial Genetics and Biotechnology
- RNA Research and Splicing
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Microbial Metabolic Engineering and Bioproduction
- RNA and protein synthesis mechanisms
- Neurobiology and Insect Physiology Research
- Pluripotent Stem Cells Research
- Bioinformatics and Genomic Networks
Yale University
2011-2018
National Research Foundation of Korea
2018
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes us uniquely human. development the a highly complex process, this process reliant on precise regulation molecular cellular events grounded in spatiotemporal transcriptome. Disruption can lead to neuropsychiatric disorders. RATIONALE regulatory, epigenomic, transcriptomic features human have not been comprehensively compiled across time, regions, or cell types. Understanding etiology disorders requires...
Genes implicated in neuropsychiatric disorders are active human fetal brain, yet difficult to study a longitudinal fashion. We demonstrate that organoids from pluripotent cells model cerebral cortical development on the molecular level before 16 weeks postconception. A multiomics analysis revealed differentially genes and enhancers, with greatest changes occurring at transition stem progenitors. Networks of converging gene enhancer modules were assembled into six four global patterns...
The corticospinal (CS) tract is involved in controlling discrete voluntary skilled movements mammals. CS arises exclusively from layer (L) 5 projection neurons of the cerebral cortex, and its formation requires L5 activity Fezf2 (Fezl, Zfp312). How this L5-specific pattern expression axonal connectivity established with such remarkable fidelity had remained elusive. Here we show that transcription factor TBR1 directly binds locus represses L6 corticothalamic to restrict origin L5. In Tbr1...