A5072153357- Advanced Proteomics Techniques and Applications
- Bioinformatics and Genomic Networks
- Mass Spectrometry Techniques and Applications
- Microbial Metabolic Engineering and Bioproduction
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Biomedical Text Mining and Ontologies
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Fish Biology and Ecology Studies
- Mitochondrial Function and Pathology
- Frailty in Older Adults
- Nanoparticle-Based Drug Delivery
- Scientific Computing and Data Management
- Aquaculture Nutrition and Growth
- EEG and Brain-Computer Interfaces
- Cancer Research and Treatment
- Reproductive biology and impacts on aquatic species
- Machine Learning in Bioinformatics
University of Southern Denmark
2018-2022
University of Thessaly
2014
We have developed ComplexBrowser, an open source, online platform for supervised analysis of quantitative proteomic data (label free and isobaric mass tag based) that focuses on protein complexes. The software uses manually curated information from CORUM Complex Portal databases to identify complex components. For the first time, we provide a Fold Change (CFC) factor identifies up- downregulated complexes based level subunits coregulation. provides interactive visualization complexes'...
Translational and post-translational control mechanisms in the cell result widely observable differences between measured gene transcription protein abundances. Herein, complexes are among most tightly controlled entities by selective degradation of their individual proteins. They furthermore act as hubs that regulate highly important processes exhibit a high functional diversity due to ability change composition structure. Better understanding prediction these states demands methods for...
In cases with sensory processing dysfunctions like autism spectrum disorder (ASD) and cognitive decline Alzheimer's disease (AD), optimistic neurological improvements have been recorded after systematic sensorimotor enrichment stimulation art therapeutic procedures. While therapy may offer a cognitive-behavioral breakthrough, several latest studies explored the effectiveness of brain signals representations through audio visual transformations electroencephalography (EEG) measurements...
The effects of complimentary compound feeds with varying protein levels on growth performance, feed utilization, and whole body composition were studied in golden grey mullet, Liza aurata. Fish initial weight 51.1±5.2 g raised hapas a coastal lagoon fed four iso-energetic diets containing 25%, 30%, 35% or 45% crude for 20 weeks. L. aurata reared the experimental showed relatively low rates (SGR ranged from 0.40 to 0.48%/day, utilization parameters (FE 0.27 0.34) among dietary groups...
Protein to protein interactions (PPI) have been studied in great detail during the last decade. The informations derived from PPI analysis can be very helpful for large scale construction of different networks and disambiguation functional orthologs within homologous sequence complexes. Several experimental techniques offered tools high throughput network mapping applications, although as long data increases massively, new computational methods arise overcome processing requirements time...
In quantitative bottom-up mass spectrometry (MS)-based proteomics the reliable estimation of protein concentration changes from peptide quantifications between different biological samples is essential. This not a single task but comprises two processes inference and abundance summarization. Furthermore, due to high complexity data associated uncertainty about performance these processes, there demand for comprehensive visualization methods able integrate with including their...
Abstract Translational and post-translational control mechanisms in the cell result widely observable differences between measured gene transcription protein abundances. Herein, complexes are among most tightly controlled entities by selective degradation of their individual proteins. They furthermore act as hubs that regulate highly important processes exhibit a high functional diversity due to ability change composition structure. To better understand predict these states, extensive...
Abstract We have developed ComplexBrowser, an open source, online platform for supervised analysis of quantitative proteomics data that focuses on protein complexes. The software uses information from CORUM and Complex Portal databases to identify complex components. Based the expression changes individual subunits across experiment it calculates Fold Change (CFC) factor characterises overall trend level subunit co-regulation. Thus up- down-regulated complexes can be identified. It provides...
Abstract Motivation In quantitative bottom-up mass spectrometry (MS)-based proteomics the reliable estimation of protein concentration changes from peptide quantifications between different biological samples is essential. This not a single task but comprises two processes inference and abundance summarization. Furthermore, due to high complexity data associated uncertainty about performance these processes, there demand for comprehensive visualization methods able integrate with including...