A5065702208- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Epilepsy research and treatment
- Neural dynamics and brain function
- MRI in cancer diagnosis
- Electron Spin Resonance Studies
- Neonatal and fetal brain pathology
- Advanced NMR Techniques and Applications
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Brain Tumor Detection and Classification
- Lanthanide and Transition Metal Complexes
- Transcranial Magnetic Stimulation Studies
- Fetal and Pediatric Neurological Disorders
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Glioma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Medical Imaging Techniques and Applications
- Anesthesia and Sedative Agents
- Mitochondrial Function and Pathology
University of Eastern Finland
2016-2025
Finland University
2000-2024
Institute for Molecular Science
2021
University of Minnesota
2002-2017
Resonance Research (United States)
2002-2017
Universidade de Santiago de Compostela
2016
University Children’s Hospital Basel
2016
University of Basel
2016
Dartmouth College
2010
North Karelia Central Hospital
2010
Resting-state functional magnetic resonance imaging (rsfMRI) is a translational method with great potential in several neurobiologic applications. Most preclinical rsfMRI studies are performed anesthetized animals, but the confounding effects of anesthesia on measured connectivity (FC) poorly understood. Therefore, we FC under six commonly used protocols and compared findings data obtained from awake rats. The results demonstrated that each protocol uniquely modulated FC. Connectivity...
Abstract One of the cardinal pathologic features Alzheimer's disease (AD) is formation senile, or amyloid, plaques. Transgenic mice have been developed that express one more genes responsible for familial AD in humans. Doubly transgenic develop “human‐like” plaques, providing a mechanism to study amyloid plaque biology controlled manner. Imaging labeled plaques has accomplished with other modalities, but only MRI sufficient spatial and contrast resolution visualize individual noninvasively....
Traumatic brain injury (TBI) causes 10-20% of acquired epilepsy, which typically develops within 2 years post-injury with poorly understood mechanisms. We investigated the location, severity, evolution and persistence blood-brain barrier (BBB) dysfunction associated neuroinflammation after TBI, their contribution to post-traumatic seizure susceptibility.TBI was induced lateral fluid-percussion in adult male Sprague-Dawley rats (6 sham, 12 TBI). Permeability BBB assessed using T1-weighted...
Zero echo time (zero-TE) pulse sequences provide a quiet and artifact-free alternative to conventional functional magnetic resonance imaging (fMRI) sequences. The fast readouts (<1 ms) utilized in zero-TE fMRI produce an image contrast with negligible contributions from blood oxygenation level-dependent (BOLD) mechanisms, yet the is highly sensitive brain function. However, precise relationship between neuronal activity has not been determined. Therefore, we aimed derive function model...
Summary: Purpose: This study examined the hypothesis that neurodegeneration continues after status epilepticus (SE) ends and severity of damage at early phase epileptogenic process predicts outcome epilepsy in a long‐term follow‐up. Methods: SE was induced rats by electrical stimulation amygdala, progression structural alterations monitored with multiparametric magnetic resonance imaging (MRI). Absolute T 2 , 1ρ diffusion (D av ) images were acquired from piriform cortex, thalamus,...
The amide proton transfer ratio (APTR) from the asymmetry of Z-spectrum was determined in rat brain tissue during and after unilateral middle cerebral artery occlusion (MCAo). Cerebral lactate (Lac) as by (1)H NMR spectroscopy, water diffusion, T(1rho) were quantified well. Lac concentrations used to estimate intracellular pH (pH(i)) MCA occlusion. A decrease APTR indicated acidification 7.1 6.79 +/- 0.19 (a drop 0.3 0.2 units), whereas pH(i) computed concentration 6.3 0.8 units). Despite...
The need to use animal models develop imaging markers that could be linked electrophysiological abnormalities in epilepsy and able predict epileptogenicity human studies is widely acknowledged. This study aimed investigate the value of early magnetic resonance (MRI) predicting long-term increased seizure susceptibility clinically relevant model post-traumatic (PTE). Moderate traumatic brain injury (TBI) was induced by lateral fluid-percussion two groups adult rats (34 injured, 16 controls)....
Traumatic brain injury (TBI) is a major cause of disability and death in people all ages worldwide. An initial caused by external mechanical forces triggers cascade tissue changes that lead to wide spectrum symptoms disabilities, such as cognitive deficits, mood or anxiety disorders, motor impairments, chronic pain, epilepsy. We investigated the detectability secondary at time-point using ex vivo diffusion tensor imaging (DTI) rat model TBI, lateral fluid percussion (LFP) injury. Our...
The adverse effects of alcohol consumption during pregnancy are known, but the molecular events that lead to phenotypic characteristics unclear. To unravel mechanisms, we have used a mouse model gestational ethanol exposure, which is based on maternal ad libitum ingestion 10% (v/v) for first 8 days gestation (GD 0.5-8.5). Early neurulation takes place by end this period, equivalent developmental stage early in fourth week post-fertilization human. During exposure dynamic epigenetic...
Functional magnetic resonance imaging (fMRI) is a powerful noninvasive tool for studying spontaneous resting state functional connectivity (RSFC) in laboratory animals. Brain function can be significantly affected by generally used anesthetics, however, rendering the need awake imaging. Only few different animal habituation protocols have been presented, and there critical practical improved low-stress techniques. Here we demonstrate novel restraint approach rat RSFC studies. Our custom-made...
Background— For clinically relevant proangiogenic therapy, it would be essential that the growth of whole vascular tree is promoted. Vascular endothelial factor (VEGF) well known to induce angiogenesis, but its capability promote larger vessels controversial. We hypothesized blood flow remodels during VEGF gene therapy and may contribute large vessels. Methods Results— Adenoviral (Ad) or LacZ control transfer was performed in rabbit hindlimb semimembranous muscles with without ligation...
We tested the hypothesis that vascular remodeling in cortex, hippocampus, and thalamus is associated with long-term functional recovery after traumatic brain injury (TBI). induced TBI lateral fluid-percussion (LFP) adult rats. Animals were followed-up for 9 months, during which we motor performance using a neuroscore test, spatial learning memory Morris water maze, seizure susceptibility pentylenetetrazol (PTZ) test. At 8 they underwent structural MRI, cerebral blood flow (CBF) was assessed...