A5023634864- Piperaceae Chemical and Biological Studies
- Essential Oils and Antimicrobial Activity
- Traditional and Medicinal Uses of Annonaceae
- Plant Toxicity and Pharmacological Properties
- Genomics, phytochemicals, and oxidative stress
- Sesquiterpenes and Asteraceae Studies
- Genetics, Aging, and Longevity in Model Organisms
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- Fermentation and Sensory Analysis
- Spaceflight effects on biology
- Ginger and Zingiberaceae research
- Neurobiology and Insect Physiology Research
- Tea Polyphenols and Effects
- Climate change and permafrost
- Polysaccharides and Plant Cell Walls
- Child and Adolescent Psychosocial and Emotional Development
- Hippo pathway signaling and YAP/TAZ
- Evolution and Genetic Dynamics
- Soil and Unsaturated Flow
- Phytochemicals and Antioxidant Activities
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- Plant-Microbe Interactions and Immunity
- Marine Sponges and Natural Products
Wuhan University
2016-2025
Zhongnan Hospital of Wuhan University
2022-2023
Guangzhou University of Chinese Medicine
2018-2022
Jinan University
2006-2021
Central South University of Forestry and Technology
2014
Central South University
2014
Tianjin University of Science and Technology
2011
Piper longum L. is widely cultivated for food, medicine, and other purposes in tropical subtropical regions. Sixteen compounds including nine new amide alkaloids were isolated from the roots of P. longum. The structures these determined by spectroscopic data. All showed better anti-inflammatory activities (IC50 = 1.90 ± 0.68–40.22 0.45 μM) compared to indomethacin 52.88 3.56 μM). Among compounds, five dimeric exhibited synergistic effects with three chemotherapeutic drugs (paclitaxel,...
This paper made a qualitative identification of ordinary vegetable oil and waste cooking based on Raman spectroscopy. spectra 73 samples four varieties were acquired through the portable spectrometer. Then, partial least squares discriminant analysis (PLS‐DA) model discrimination characteristic wave band ratio established. A classification variable olive oil, peanut corn that was established PLS‐DA could identify accurately from oils. The selection waveband characteristics intensity...
In the current study, nine amide alkaloids, including two new dimeric amides and a natural product, were identified from Piper nigrum. Among them, seven compounds sensitized paclitaxel-resistant cervical cancer cells HeLa/PTX to paclitaxel. Piperine was major component obtained nigrum, its sensitization mechanism investigated. Combination treatment enhanced cell apoptosis, which mediated by downregulation of phospho-Akt Mcl-1. (50 μM) combined with paclitaxel (200 nM) downregulated Mcl-1...
Abstract Objectives To explore effective extraction method and to find active constituents, we investigated the biological activity of three extracts isolated compounds from fruits Piper longum L. Methods Three were obtained by reflux, ultrasonic supercritical fluid extraction, respectively. Active bioassay-guided method. The anti-inflammatory activity, antiproliferation cytotoxicity evaluated. apoptosis was detected Hoechst 33258 staining assay. relevant proteins Western blot Key findings...
Non-suicidal self-injury (NSSI) is a significant public health concern that threatens the physical and mental of adolescents. Given its high prevalence among adolescents, understanding characteristics contributing factors NSSI crucial. This study aimed to characterize examine relationship between self-control adolescent psychiatric outpatients. was conducted in department hospital Hubei Province, China, involving 206 outpatients (135 females, 12-18 years old). Assessments included Ottawa...
The homeotic transformation of stamens into pistil-like structures (pistillody) causes cytoplasmic male sterility (CMS). This phenomenon is widely present in plants, and might be induced by intracellular communication (mitochondrial retrograde signaling), but its systemic regulating mechanism still unclear. In this study, morphological observation showed that the transformed structures, leading to flat dehiscent pistils, fruit set decrease sua-CMS (MS K326, somatic fusion between Nicotiana....
Two novel monoterpenoid indole alkaloids, alstolarines A and B (<bold>1</bold> <bold>2</bold>), were isolated from <italic>Alstonia scholaris</italic>, exhibited promising vasorelaxant activities.
Background Genuine Chinese medicine is produced from medicinal plant cultivated in a specific region and of better quality efficacy, more consistently qualified famous than that the same other regions. The cultivating genuine known as producing area. Yangchun City, which Guangdong Province China, area for Amomi Fructus (also called Sharen). ripe dry fruit Zingiberaceae A . villosum Lour.. was introduced Persian Gulf has been China over 1000 years. Until now there are no reports on screening...
Spiroalanfurantones A-D (1-4), four eudesmanolide-furan sesquiterpene adducts with an unprecedented pentacyclic 6/6/5/5/5 skeleton, were isolated from the roots of Inula helenium. Their structures elucidated by spectroscopic data analysis and single-crystal X-ray diffraction analysis. The plausible biosynthetic pathway for 1-4 is presented. Bioassay showed that compounds 1 2 significantly inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages IC50 values 17.3...
The scorpion has been extensively used in various pharmacological profiles or as food supplies. exploration of venom reported due to the presence recombinant peptides. rBmαTX14 is an α-neurotoxin extracted from gland East Asian Buthus martensii Karsch and can affect ion channel conductance. Here, we investigated functions using Caenorhabditis elegans model. Using western blot analysis, was shown be expressed both cytoplasm inclusion bodies E.coli Rosetta (DE3) strain. Circular dichroism...
// Kaixuan Teng 1, * , Cuilan Deng Jie Xu 1 Qiuxu Men Tao Lei Da Di Ting Liu 2 Wenhua Li Xin Ministry of Education Laboratory Combinatorial Biosynthesis and Drug Discovery, College Pharmacy, Wuhan University, Wuhan, 430071, P.R. China Life Sciences, 430072, These authors contributed equally to this work Correspondence to: Liu, e-mail: lx@whu.edu.cn Keywords: transcription enhancer factor 3 isoform angiogenesis, cell cycle, HUVEC, cancer therapy Received: November 09,...
In order to set up a technical standard for planting Amomum villosum in wood forest the future, we analyzed relationship between ecological factors and yield of A. planted five Dimocarpus imocarpus longan forests miscellaneous Yangchun city, find out dominant that affect villosum. The results showed agricultural measures fertilization, artificial irrigation removing old plants were positively correlated with villosum, pesticide spraying soil pH value negatively But effects on not...
Three novel monoterpenoid indole alkaloids gardflorine A (