The aim of this work was to evaluate the effect administration egg white hydrolysates on obesity-related disorders, with a focus lipid metabolism, inflammation and oxidative stress, in Zucker fatty rats. Obese rats received water, pepsin hydrolysate (750 mg/kg/day) or Rhizopus aminopeptidase for 12 weeks. Lean water. Body weight, solid liquid intakes were weekly measured. At end study, urine, faeces, different organs blood samples collected. consumption hydrolysed significantly decreased...

Studies in isolated preparations of vascular tissue (mainly resistance vessels) provide evidence that anandamide exerts vasorelaxation. The aim the present work was to further characterize mechanisms involved response induced by a conduit vessel, rat aorta.Isometric tension changes cumulative concentration-response curve (1 nM-100 micro M) were recorded aortic rings from male Wistar rats. involvement number factors this relaxation investigated including endothelium-derived vasorelaxant...

Diabetes increases cardiac damage after myocardial ischaemia. Cannabinoids can protect against ischaemia/reperfusion injury. The aim of this study was to examine the cardioprotective effect cannabinoid agonist WIN 55,212-2 (WIN) injury in an experimental model type 2 diabetes. We performed these experiments Zucker diabetic fatty rat, and focused on role receptors modulation inducible nitric oxide synthase (iNOS)/endothelial-type (eNOS) expression.Male 20-week-old rats were treated with...

In the last years, many clinical studies have revealed that some cisplatin-treated cancer survivors a significantly increased risk of cardiovascular events, being cisplatin-induced toxicity an increasing concern. The aim present work was to evaluate alterations induced by different chronic cisplatin treatments, and identify mechanisms involved. Direct blood pressure, basal cardiac (left ventricle coronary arteries) vascular (aortic mesenteric) functions were evaluated in (5 weeks) saline- or...

Vincristine is an effective anticancer agent for treating leukemias, lymphomas, and other solid tumors. Vincristine’s better-known severe side effects include bone marrow depression, hyponatremia, peripheral neuropathy, gastrointestinal distress. In recent years, cardiovascular damage also has been described during vincristine treatments. However, the vascular toxicity induced by little studied. The aim of present to evaluate whether these alterations remain after suspension chemotherapy...

The use of cannabinoids to treat gastrointestinal (GI) motor disorders has considerable potential. However, it is not clear if tolerance their actions develops peripherally, as does centrally. aim this study was examine the chronic effects cannabinoid agonist WIN 55,212-2 (WIN) on GI motility, well those in central nervous and cardiovascular systems. administered for 14 days, at either non-psychoactive or psychoactive doses. Cardiovascular parameters were measured anaesthetized rats, whereas...

Abstract Background Cannabinoids acutely administered depress central, cardiovascular and gastrointestinal functions. These effects might be modified upon repeated administration. Compared to the induced by daily administration, those intermittent administration are less known. The effect of treatment with CB1/CB2 cannabinoid agonist WIN55,212‐2 (WIN) was studied in rat. Methods Male rats received saline, vehicle or WIN at 0.5 (low‐WIN) 5 (high‐WIN) mg kg −1 week for 4 weeks. on central...

Resveratrol is a polyphenol present in grapes, some nuts and dried fruits, red wine. A number of beneficial properties have been attributed to this compound. Its potential neuroprotective effects are the subject much research today.To review resveratrol, more particularly those related its capacity offer protection against neurodegeneration associated with several pathologies traumatic injuries central nervous system.It has suggested that daily consumption wine, therefore could account for...

Abstract Background Monosodium glutamate ( MSG ) is a flavor‐enhancer widely used as food additive. However, its safe dietary concentration and toxicity, including possible implication in the recent metabolic syndrome pandemia, still controversial issue. Therefore, deep knowledge of effects upon regular use needed. Our aim was to evaluate chronic exposure on feeding behavior, abdominal fat, gastrointestinal motility, cardiovascular function rats. Methods Two groups adult male Wistar rats...

The aim of this study was to examine the effect a pepsin egg white hydrolysate (EWH) on metabolic complications using high-fat/high-dextrose diet-induced Metabolic Syndrome (MetS) experimental model. Male Wistar rats were divided into 4 groups which received: standard diet and water (C), solution with 1 g kg-1 day-1 EWH (CH), (MS), (MSH). consumption normalized body weight gain; abdominal obesity peripheral neuropathy developed in MetS animals, adipose tissue liver weight, as well plasma...

Abstract Background Vincristine is a commonly used chemotherapeutic agent. It associated with undesirable digestive side effects. However, the impact of vincristine on gastrointestinal structure and motility or its long‐term effects have not been deeply studied in animal models. This could be useful order to develop therapeutic preventive strategies for cancer patients. The aim this study was analyze such Methods Rats received saline (0.1 mg kg −1 , ip) daily 10 days. Evaluations were...

Abstract Background E‐52862 (S1RA, 4‐[2‐[[5‐methyl‐1‐(2‐naphthalenyl)‐1H‐pyrazol‐3‐yl]oxy]ethyl]‐morpholine), a novel selective sigma 1 receptor (σ1R) antagonist, has demonstrated efficacy in nociceptive and neuropathic pain models. Our aim was to test if σ1R blockade with may modify the signs of neuropathy Zucker diabetic fatty (ZDF) rats, type 2 diabetes model. Methods Mechanical thermal response thresholds were tested on 7‐, 13‐, 14‐ 15‐week‐old ZDF rats treated saline or acutely...

The purpose of this study was to evaluate the effect administration two egg white hydrolysates on glucose metabolism complications related Metabolic Syndrome (MS) in Zucker fatty rats (ZFR). ZFR were given 750 mg/kg/day hydrolyzed with pepsin (HEW1) or aminopeptidase (HEW2) for 12 weeks their drinking water just water. lean (ZLR), which received water, used as a control. presence tactile allodynia, is sign peripheral neuropathy, assessed. Blood samples and pancreas collected determine...

Cisplatin is clinically proven to combat different cancers, including sarcomas, soft tissue bones, muscles, and blood. However, renal cardiovascular toxicities are important limitations in cisplatin therapeutical use. Immunoinflammation could be key factor cisplatin-induced toxicity. The aim of the present study was evaluate activation inflammatory TLR4/NLRP3 pathway as a common mechanism for cisplatin's cycles treatment Adult male Wistar rats were treated with saline, 2 mg/kg or 3...

We have compared the mechanisms involved in sodium nitroprusside (SNP)‐induced relaxation and [Ca 2+ ] i reduction isolated piglet pulmonary (PA) mesenteric (MA) arteries. SNP (10 −8 M −3×10 −5 ) evoked a concentration‐dependent of PA MA (pD 2 =6.66±0.06 6.74±0.14, respectively) stimulated by noradrenaline, which was markedly reduced guanylate cyclase inhibitor ODQ. In fura 2‐incubated MA, produced parallel contractile force , expressed as ratio emitted fluorescence at 340 380 nm...

Abstract Background Chemotherapy‐induced adverse effects are an unresolved nightmare. In preclinical studies in rats, the food additive monosodium glutamate (MSG) improved some of side caused by cisplatin, but its other models chemotherapy‐treated animals not well known. The aim this study was to test if MSG may improve induced vincristine rats. Methods Young male Wistar rats were exposed or (4 g L −1 ) drinking water from week 0 till 1 after treatment (week 3). Rats received two cycles five...

Cancer chemotherapy is not free of undesirable side effects. With respect to the cardiovascular system, cardiotoxicity a well-described and potentially lethal effect certain chemotherapeutic agents, such as anthracyclines. However, in last few years, several clinical studies have taken into account fact that some non-anthracycline treated-patients also significantly increased risk events. The exact mechanism this toxicity known, possibilities, including vascular autonomic neuropathy damage,...

Abstract Background Food and diet are central issues for proper functioning of the cardiovascular (CV) system gastrointestinal (GI) tract. We hypothesize that different types dietary FAs affect CV parameters as well GI motor function visceral sensitivity. Methods Male Wistar rats were fed with control (CTRL), supplemented 7% soybean oil (SOY), SOY + 3.5% virgin coconut (COCO), evening primrose (EP) 4 weeks. The content insoluble fiber in CTRL was higher than SOY, COCO, or EP. Body weight...

Abstract Background The antineoplastic drugs cisplatin and vincristine induce peripheral neuropathies. sigma‐1 receptor (σ1R) is expressed in areas of pain control, its blockade with the novel selective antagonist MR ‐309 has shown efficacy nociceptive neuropathic models. Our goal was to test whether this compound reduces signs provoked by these antitumoural drugs. Methods Rats were treated or effects acute repeated administration tested on mechanical thermal sensitivity,...

Metabolic Syndrome (MS) is related to increased risk of early death due cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost-effective alternative for treatment those alterations in patients with MS. The aim this study was investigate effects different egg white hydrolysates (HEW1 HEW2) obese Zucker rats, focus on development complications. Blood pressure, heart rate, basal cardiac function vascular reactivity aorta mesenteric...