The aqueous extract of Portulaca oleracea was used as a biocatalyst for the reduction Na2SeO3 to form Se-NPs that appeared red in color and showed maximum surface plasmon resonance at wavelength 266 nm, indicating successful Phyto-fabrication Se-NPs. A FT-IR chart clarified role plant metabolites such proteins, carbohydrates, amino acids capping stabilizing TEM, SAED, XRD analyses indicated formation spherical, well-arranged, crystalline with sizes range 2-22 nm. SEM-EDX mapping peaks Se...

Oxaliplatin (Oxa)-associated adverse side effects have considerably limited the clinical use of drug in colon cancer therapy. Mutant p53 has diverse mutational profiles cancer, and it influences potencies various chemotherapeutic drugs, including Oxa. Thus, would be highly beneficial to identify an alternative therapeutic strategy that not only reduces toxicity Oxa, but also exerts a synergistic effect against cancers, regardless their profiles. The present study was aimed at preparing...

Abstract This systematic review highlights the urgent need to explore nutritional and therapeutic potential of Samh, or Mesembryanthemum forskahlii Hochst. ex Boiss. (M. forskalii) in response global health challenges growing interest functional foods. Out 184 records, thirty were chosen for review, comprising 24 articles 6 books. The revealed that 83.33% studies concentrated on samh seeds. A comprehensive analysis identified 128 distinctive compounds categorized them into 10 classes, with...

ABSTRACT To advance our study on the GLUT's glucose recognition binding site and enhance effectiveness of targeted anticancer compounds based encouraging findings, glycogenated metal complexes have shown promise in combating colon cancer (HCT‐116) through salicylaldehyde‐D‐glucosamine Schiff base(H 2 L), we proceed with research utilizing various cell lines different ions known for their potent effect. Newly synthesized formulae Zn (HL) , (CH 3 ) Sn(HL) [Ru(L)(HL)H O].H O are directed...

Abstract The chemotherapeutic drugs, loaded in nanocarriers, have recently attracted the pharmaceutical industries due to their limited adverse side effects. objective of current study was incorporate ifosfamide (IFO) into two different essential oils-based nanoemulsions, lemon (LEM-IFO) and salvia (SAL-IFO). antiproliferation activities resulted formulas were evaluated MCF-7 breast cancer cells HeLa cervical cancers cells. cytotoxic effect NE detected by MTT assay, DAPI stain light...

Phormidesmis communis strain AB_11_10 was isolated and identified using microscopy 16s rRNA sequencing, its phytochemical constituents were determined liquid chromatography-quadrupole time-of-flight mass spectrometry. The isolate had a segmented filamentous shape with blue-green color. Many biomolecules, including organic compounds, amino acids, fatty detected. P. used to synthesize gold nanoparticles (Ph-AuNPs) by adjusting the optimum reaction conditions. concentration, algal/precursor...

The anticancer effects of chemotherapeutic agents may be accentuated, and their side minimized by combining them with essential oils in nanocarrier systems. This study aimed to incorporate ifosfamide (IF) into nanoemulsion-based clove oil (IF-CLV). nano-emulsion (NE) formulas were characterized Zetasizer. cytotoxicity the formulated NEs against cervical (HeLa) breast (MCF-7) cancer cell lines was determined using MTT assay, light microscopy, DAPI staining. z – average diameters NE-CLV IF-CLV...

This study was aimed at investigating the cytotoxic effect of a novel combination doxorubicin (DOX) and nano-formulation

<span style="color: #1f497d;">Introduction: Nephrotoxicity is one of the major side effects chemotherapeutic drug, ifosfamide (IFO). In this study, IFO was solubilized in nanoemulsion (NE) containing salvia (SAL) essential oil to investigate its adverse mice. <br /> #1f497d;">Methods: One hundred female Swiss albino mice (n = 20/group) were split into five groups. Group I (Normal) received saline solution (0.9% (w/v) NaCl) while groups II-V intraperitoneally (I.P.) injected...

(2021). Preparation, characterization, optimization, and antibacterial evaluation of nano-emulsion incorporating essential oil extracted from Teucrium polium L. Journal Dispersion Science Technology. Ahead Print.

The limitations of gemcitabine (GEM) in cancer therapy are due to its poor pharmacokinetics, which cause undesired adverse effects. current study was aimed at investigating the anticancer effect and apoptotic mechanism synthesized nanoemulsion (NE) containing Pulicaria crispa essential oil (PC-EO) GEM (PC-NE:GEM) on MCF-7 Hep-G2 cell lines. An optimized NE formulation selected based Box–Behnken method. droplet size PC-NE 9.93 ± 0.53 nm, but after loading, it increased 11.36 0.0.21 nm....

The transcription factor, heat shock factor 1 (HSF1), influences the expression of proteins as well other activities like induction tumor suppressor genes, signal transduction pathway, and glucose metabolism. We hypothesized that single nucleotide polymorphisms (SNPs) in HSF1 gene might affect its or function which have an influence on development breast cancer. study group included 242 individuals (146 cancer patients 96 healthy controls). From patients, genomic DNA was extracted from blood...

Purpose: To investigate the hepatotoxic and hematotoxic effects of sage oil-loaded ifosfamide (IFO) nanoemulsion (NE) in Ehrlich ascites carcinoma (EAC)-bearing mice.
 Methods: Ifosfamide was loaded into a NE containing oil, its were assessed EAC-bearing mice. Female Swiss albino mice (n = 50) weighing 25 - 30 g (mean weight 27.5 ± 2.50 g) randomly assigned to five groups ten each. With exception group 1, inoculated intraperitoneally (i.p.) with 2.5 × 106 EAC/mouse for 48 h. Group I...