A5053096717- Parkinson's Disease Mechanisms and Treatments
- Developmental Biology and Gene Regulation
- Microtubule and mitosis dynamics
- Cardiac electrophysiology and arrhythmias
- Photosynthetic Processes and Mechanisms
- Silk-based biomaterials and applications
- Neurobiology and Insect Physiology Research
- Cellular transport and secretion
- Nuclear Receptors and Signaling
- Receptor Mechanisms and Signaling
- Plant Molecular Biology Research
- Amyotrophic Lateral Sclerosis Research
- RNA regulation and disease
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Ion channel regulation and function
University of Michigan
2022
Penn State Milton S. Hershey Medical Center
2020-2021
Pennsylvania State University
2014-2021
Hershey (United States)
2020
Grove City College
2011
Mayo Clinic
2010-2011
Microtubule minus ends are thought to be stable in cells. Surprisingly, Drosophila and zebrafish neurons, we observed persistent end growth, with runs lasting over 10 min. In Drosophila, extended growth depended on Patronin, Patronin reduction disrupted dendritic minus-end-out polarity. fly dendrites, microtubule nucleation sites localize at dendrite branch points. Therefore, hypothesized might particularly important beyond Distal dendrites have mixed polarity, of lowered the number...
Axon injury triggers regeneration through activation of a conserved kinase cascade, which includes the dual leucine zipper (DLK). Although dendrites are damaged during stroke, traumatic brain injury, and seizure, it is not known whether mature neurons monitor dendrite initiate regeneration. We probed response to damage using model Drosophila neurons. Two larval neuron types regrew in distinct ways after all were removed. Dendrite was also triggered by adults. Next, we tested initiated with...
While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury. Using a Drosophila model dendrite regeneration, we performed candidate screen receptor tyrosine kinases (RTKs) and found requirement for RTK-like orphan (Ror). We confirmed Ror was required in two different neuron types using RNA interference (RNAi) mutants. not or normal development, suggesting specific role regeneration. can act as Wnt...
Kinetochores connect centromeric chromatin to spindle microtubules during mitosis. Neurons are postmitotic, so it was surprising identify transcripts of structural kinetochore (KT) proteins and regulatory chromosome passenger complex (CPC) assembly checkpoint (SAC) in Drosophila neurons after dendrite injury. To test whether these function regeneration, postmitotic RNA interference (RNAi) performed dendrites or axons were removed using laser microsurgery. Reduction KT, CPC, SAC decreased...
Riluzole is a glutamate inhibitor approved for the treatment of amyotrophic lateral sclerosis (ALS). There are scant data on factors associated with riluzole initiation and adherence. The goal this study was to describe use at Penn State Hershey Medical Center (PSHMC) ALS clinic.A retrospective medical record review patients seen PSHMC from January 2007 December 2016. A timeline established each patient. Factors contributing dose changes or discontinuations were recorded. adherence assessed...
Background: Recent randomized clinical trials using hydrophobic statins reported no influence on Parkinson’s disease (PD) progression. Hydrophobicity is a key determinant for blood-brain barrier penetrance. Objective: Investigate potential effect of PD Methods: Statin use was determined at baseline and subtyped according to hydrophobicity in 125 patients participating the Biomarker Program (PDBP, 2012–2015) our site. Clinical (N = 125) susceptibility MRI 86) data were obtained 18-months....