A5078930677- Bioactive Compounds and Antitumor Agents
- Ion channel regulation and function
- Chemical Reaction Mechanisms
- Synthesis and Biological Evaluation
- Synthesis of heterocyclic compounds
- Mitochondrial Function and Pathology
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Neuroscience and Neuropharmacology Research
- Synthesis and Reactions of Organic Compounds
- Free Radicals and Antioxidants
- Cardiac electrophysiology and arrhythmias
- Biochemical Acid Research Studies
- DNA and Nucleic Acid Chemistry
- Neuroscience and Neural Engineering
- Acute Kidney Injury Research
- Analytical Chemistry and Chromatography
- Plant-based Medicinal Research
- Antioxidant Activity and Oxidative Stress
- Pharmacological Receptor Mechanisms and Effects
- Synthesis of Organic Compounds
- Inorganic and Organometallic Chemistry
- Receptor Mechanisms and Signaling
- Chemokine receptors and signaling
Latvijas Organiskās Sintēzes Institūts
1999-2023
Institute of Organic Synthesis
2016-2022
Latvian Academy of Sciences
1993
Oxidative stress has been implicated in pathophysiology of different human stress- and age-associated disorders, including osteoporosis for which antioxidants could be considered as therapeutic remedies was suggested recently. The 1,4-dihydropyridine (DHP) derivatives are known their pleiotropic activity, with some also acting antioxidants. To find compounds potential antioxidative a group 27 structurally diverse DHPs, well one pyridine compound, were studied. A 11 DHPs 10-fold higher than...
The effects of eleven 1,4‐dihydropyridine derivatives (DHPs) used alone or together with prooxidant anticancer drug doxorubicin were examined on two cancer (HOS, HeLa) and nonmalignant cell lines (HMEC, L929). Their the growth ( 3 H‐thymidine incorporation) compared their antiradical activities (DPPH assay), using well‐known DHP antioxidant diludine as a reference. Thus, tested DHPs belong to three groups: (1) diludine; (2) pyridinium moieties at position 4 1,4‐DHP ring; (3) containing...
A group of 26 2,6-dimethyl-3,5-disubstituted and 2,6-dimethyl-3,4, 5-trisubstituted-1,4-dihydropyridines (1,4-H(2)Py=1,4-DHPs) five related pyridines were studied as inhibitors rat liver mitochondrial swelling O(2) uptake by ascorbic acid-dependent lipid peroxidation (LP) modulators induced Na(+)-linoleate or Na(+)-pyrophosphate. 1,4-DHPs include 4-unsubstituted 4-methyl- 4-phenyl-substituted 3, 5-dialkoxycarbonylderivatives 2,6-dimethyl-1,4-DHP with variations in alkoxy chain length...
The influence of the 1,4-dihydropyridines (DHPs), water-soluble glutapyrone available as sodium, potassium and ammonium salts 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-DHP-4-carboxamide)glutaric acid, from one side, a lipophylic cerebrocrast, 2-propoxyethyl 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-DHP-3,5-dicarboxylate, other on partially damaged mitochondria Wistar rat hindlimb muscle was also studied. following tests were made: (1) rates endogenous respiration substrate (succinate)...
The paradigm of ligand-receptor interactions postulated as "one compound-one target" has been evolving; a multi-target, pleiotropic approach is now considered to be realistic. Novel series 1,4,5,6,7,8-hexahydro-5-oxoquinolines, pyranopyrimidines and S-alkyl derivatives have synthesized in order characterise their pleiotropic, multitarget activity on the FFA3/GPR41, FFA2/GPR43, HCA2/GPR109A receptors. Hexahydroquinoline known exhibit characteristic FFA3/GPR41 ligands, but during this study we...
Background & Objective: Various 1,4-dihydropyridines (DHPs) could affect basic and cell-type specific mitochondrial functions in different way at various extent either as protectors or harmful compounds, depending on their lipophylicity chemical modifications of the DHP nucleus. Hence, several DHPs may affect: 1) bioenergetics well enzymatic activities including electron transport chain reactions organic acids consumption rate; 2) lipid peroxidation, production reactive oxygen species...
A set of six new 4-pyridinio-1,4-dihydropyridine (1,4-DHP) compounds has been synthesized. The calcium channel modulating activity these was evaluated in an aorta vascular smooth muscle cell line (A7R5), isolated rat aortic ring model, and human neuroblastoma lines (SH-SY5Y). antagonistic effect 1,4-DHP tested by the impact carbachol-dependent mobilization intracellular Ca 2+ SH-SY5Y cells. free concentration measured confluent monolayers cells A7R5 with -sensitive fluorescent indicator...
The review summarizes data on genome protecting and genotoxic action of 1,4-dihydropyridines (DHP) with main focus the compounds synthesized in Latvian Institute Organic synthesis. Most these manifest very low calcium channel blocking activity, thus considered to be “unusual” 1,4-DHP. Some decrease spontaneous mutagenesis frequency mutations induced by chemical mutagens. water-soluble 1,4-DHP protect DNA against damage produced hydrogen peroxide, radiation peroxynitrite. In molecules...