A5025072463- Inflammasome and immune disorders
- Erythrocyte Function and Pathophysiology
- Toxin Mechanisms and Immunotoxins
- Synthesis and bioactivity of alkaloids
- Effects and risks of endocrine disrupting chemicals
- Berberine and alkaloids research
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects and Assays
- Protease and Inhibitor Mechanisms
- Herbal Medicine Research Studies
- Pharmacological Effects of Natural Compounds
- Plant Toxicity and Pharmacological Properties
- Bacterial biofilms and quorum sensing
- Neuroscience and Neural Engineering
- Metabolomics and Mass Spectrometry Studies
- Transcranial Magnetic Stimulation Studies
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Transgenic Plants and Applications
- Bacterial Genetics and Biotechnology
- Peptidase Inhibition and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
Korea Institute of Science and Technology
2017-2024
Yonsei University
2017-2023
Abstract Parkinson's disease (PD) is a progressive neurodegenerative characterized by the loss of dopaminergic neurons in substantia nigra (SN) and reduction dopamine levels striatum. Although details molecular mechanisms underlying neuronal death PD remain unclear, neuroinflammation also considered potent mediator pathogenesis progression PD. In present study, we evidences that microglial NLRP3 inflammasome activation critical for subsequent motor deficits...
Inflammasome signaling can contribute to host innate immune defense against bacterial pathogens such as Pseudomonas aeruginosa. However, evasion of inflammasome activation is still poorly elucidated. Quorum sensing (QS) a communication mechanism that promotes coordinated adaptation by triggering expression wide range genes. QS thought strongly the virulence P. aeruginosa, but molecular impact on completely unknown. Here, we present evidence QS-related factors secretant (BS) from aeruginosa...
Ptaquiloside, a naturally occurring cancer-causing substance in bracken fern, has been detected the meat and milk of cows fed diet containing fern. A rapid sensitive method for quantitative analysis ptaquiloside meat, dairy products was developed using QuEChERS liquid chromatography–tandem mass spectrometry. The validated according to Association Official Analytical Chemists guidelines met criteria. single matrix-matched calibration with fern proposed, which is novel strategy that uses one...
The continuous consumption of various foods increases the risk unintentional exposure to residual contaminants.
Abstract The erythrocyte membrane is composed of a phospholipid bilayer, which known to undergo physicochemical changes during storage at low temperatures. This study was conducted identify marker phospholipids that indicate alteration deep‐frozen and determine the amount phospholipids. Our research suggested method detect by profiling analysis thermally injured red blood cells (RBCs) without protecting agents. Human stored −80°C for 72 days. RBC were extracted through modified Bligh Dyer...
As β-carboline (βC) alkaloids, posing potential health risks, are present in a wide variety of foods, determining the exposure degrees food to these alkaloids from dietary activity is key ensuring safety. Here, we developed rapid and sensitive simultaneous analytical method for six βC food. We optimized buffered QuEChERS method, which includes clean-up process through dispersive solid phase extraction, extract target compounds matrices; then, were detected via liquid chromatography-tandem...
Ricinine, a toxic compound found in castor plants (Ricinus communis), causes abdominal pain, nausea, and vomiting. Castor leaves oil-based dietary supplements are commonly consumed, but their ricinine content has not been evaluated for safety. This study aimed to determine the concentration these products evaluate exposure level from consumption. The developed method combines Quick, Easy, Cheap, Effective, Rugged, Safe (QuEChERS) technique liquid chromatography–tandem mass spectrometry...
Procollagen type III N-terminal peptide (P-III-NP) is a fibrosis biomarker associated with liver and cardiac fibrosis. Despite the value of P-III-NP as biomarker, its analysis currently relies on enzyme-linked immunosorbent assays (ELISA) radioimmunoassays (RIA), which require more than 3 h. To facilitate early diagnosis treatment through rapid testing, we developed one-step immunoassay for using quenchbody, fluorescence-labeled immunosensor immediate signal generation. create quenchbodies,...
Ricinine, an alkaloid plant toxin present in castor leaf (Ricinus communis), causes abdominal pain, nausea and vomiting. In South Korea, leaves are consumed as foods or oil-based dietary supplements commercially available. This study validates a rapid reliable method for quantifying ricinine levels natural products supplements. The combines the Quick, Easy, Cheap, Effective, Rugged, Safe (QuEChERS) technique liquid chromatography–tandem mass spectrometry (LC/MS). A matrix-matched calibration...
Brain doping is a novel form of that involves stimulating specific brain regions to enhance sports performance. However, the best our knowledge, there currently no established provision or detection method for it. As stimulation ultimately induces alterations in neurochemical concentrations, this study aimed develop diagnostic strategy doping. We successfully developed and validated sensitive simultaneous analysis 23 neurochemicals present urine. Simple derivatization was employed overcome...