A5055531381- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Urological Disorders and Treatments
- Plant Pathogenic Bacteria Studies
- Muscle Physiology and Disorders
- Evaluation and Performance Assessment
- Cell Adhesion Molecules Research
- Plant Virus Research Studies
- Epilepsy research and treatment
- Veterinary Equine Medical Research
- Genetic Syndromes and Imprinting
- Autism Spectrum Disorder Research
- Ion channel regulation and function
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
- Veterinary Medicine and Surgery
- Herpesvirus Infections and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Quality and Management
- Kidney Stones and Urolithiasis Treatments
University of California, Davis
2024-2025
University of Minnesota
2020-2021
Abstract Anhidrosis is defined as a decreased or absent ability to sweat in response heat and exercise. In horses, this condition can increase the risk of life‐threatening hyperthermia. A prior study has suggested that equine anhidrosis associated with missense variant (rs68643109) Potassium Voltage‐Gated Channel Subfamily E Regulatory Subunit 4 ( KCNE4 ) gene. This project aimed validate association population well‐phenotyped horses determine allele frequency publicly available whole‐genome...
Altered melanosome transport in melanocytes, resulting from variants the melanophilin (MLPH) gene, are associated with inherited forms of coat color dilution many species. In dogs, MLPH gene corresponds to D locus and two variants, c.−22G > A (d1) c.705G C (d2), leading color, as described. Here, we describe independent investigations dogs whose could not be explained by known who report a third variant, (c.667_668insC) (d3), which leads frameshift premature stop codon (p.His223Profs*41)....
Acromelanism is a form of albinism that results from pigmentation being affected by temperature and causes 'Himalayan' or 'colorpoint' coat pattern in animals. Tyrosinase, encoded the TYR gene, an enzyme essential for biosynthesis melanin (Slominski, 2002). The Himalayan color, where extremities are darker torso remains lighter, due to mutations result temperature-sensitive tyrosinase protein synthesis occur only cooler areas body. Mutations associated with Himalayan-type phenotype have been...
The features of juvenile-onset calcium oxalate urolithiasis in dogs have not been previously reported.Calcium urolith submissions to the Minnesota Urolith Center between 2012 and 2016 were analyzed identify those originating from juvenile (≤2 years, n = 510) or mature (7-9 39,093) dogs. Breed, sex, salt type location compared groups. Breeds represented both groups also with respect location.French (odds ratios [OR] 14.7, p < 0.001) English (OR 14.3, Bulldogs overrepresented submissions. All...
Genotyping results are presented in the manuscript Table 1.