A5033550940- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related gene regulation
- Prion Diseases and Protein Misfolding
- Genomics and Chromatin Dynamics
- Heat shock proteins research
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Fungal and yeast genetics research
Van Andel Institute
2025
Central Michigan University
2021-2024
Hematopoietic stem and progenitor cells (HSPCs) arise only during embryonic development, their identity specification, emergence from the floor of dorsal aorta, proliferation are all tightly regulated by molecular mechanisms such as signaling cues. Among these, Wnt plays an important role in HSPC differentiation, self-renewal, requiring precise modulation for proper development homeostasis. is initiated when a ligand binds to cell surface receptors those encoded frizzled gene family,...
The regulation of maternal mRNAs is essential for proper oogenesis, the production viable gametes, and to avoid birth defects infertility. Many oogenic RNA-binding proteins have been identified with roles in mRNA metabolism, some which localize dynamic ribonucleoprotein granules others that appear dispersed. Here, we use a combination vitro condensation assays vivo
Abstract One emerging paradigm of cellular organization RNA and RNA-binding proteins is the formation membraneless organelles. Examples organelles include several types ribonucleoprotein granules that form via phase separation. A variety intracellular pH changes posttranslational modifications, as well extracellular stresses, can stimulate condensation into granules. For example, assembly stress induced by oxidative stress, osmotic heat has been characterized in a somatic cell types. In germ...
Abstract The germ line provides an excellent in vivo system to study the regulation and function of RNP granules. Germ granules are conserved line-specific that positioned Caenorhabditis elegans adult gonad RNA maintenance, regulation, surveillance. In elegans, when oogenesis undergoes extended meiotic arrest, granule proteins other RNA-binding assemble into much larger whose hypothesized is regulate metabolism maintain oocyte quality. To gain insight granules, this report, we characterize...
The regulation of maternal mRNAs is essential for proper oogenesis, the production viable gametes, and to avoid birth defects infertility. Many oogenic RNA-binding proteins have been identified with roles in mRNA metabolism, some which localize dynamic ribonucleoprotein granules others that appear dispersed. Here, we use a combination
ABSTRACT The germ line provides an excellent in vivo system to study the regulation and function of RNP granules. Germ granules are conserved line-specific that positioned C. elegans adult gonad RNA maintenance, regulation, surveillance. In , when oogenesis undergoes extended meiotic arrest, granule proteins other binding assemble into much larger whose hypothesized is regulate metabolism maintain oocyte quality. To gain insight granules, this report we characterize distinct phases for four...
ABSTRACT One emerging paradigm of cellular organization RNA and binding proteins is the formation membraneless organelles (MLOs). Examples MLOs include several types ribonucleoprotein granules that form via phase separation. A variety intracellular pH changes post-translational modifications, as well extracellular stresses can stimulate condensation into granules. For example, assembly stress induced by oxidative stress, osmotic heat has been well-characterized in a somatic cell types. In...