A5093531241- Nuclear Structure and Function
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Medical Imaging and Pathology Studies
- Retinoids in leukemia and cellular processes
- Heat shock proteins research
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
Institute of Cytology
2024
Russian Academy of Sciences
2023
Natural aging and age-related diseases involve the acceleration of replicative aging, or senescence. Multiple proteins are known to participate in these processes, including promyelocytic leukemia (PML) protein, which serves as a core component nuclear-membrane-less organelles PML nuclear bodies (PML-NBs). In this work, morphological changes PML-NBs alterations protein localization at transition primary fibroblasts senescent state were studied by immunofluorescence. The obtained from both...
This study investigates the localization and functional role of TRIM27, USP7, PML protein complex. Utilizing confocal microscopy techniques bioinformatic analysis, we demonstrate existence a stable TRIM27-USP7-PML Furthermore, show that approximately 25 % TRIM27 partners interact with primary function this group being associated negative regulation DNA transcription.
In recent years, the role of liquid–liquid phase separation (LLPS) and intrinsically disordered proteins (IDPs) in cellular molecular processes has received increasing attention from researchers. One such protein is TSPYL5, considered both as a marker potential therapeutic target for various oncological diseases. However, TSPYL5 intracellular remains unknown, there no clarity even its localization. this study, we characterized localization exchange dynamics with contents parts, utilizing...