A5101627952- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Natural product bioactivities and synthesis
- Antifungal resistance and susceptibility
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Bacterial Identification and Susceptibility Testing
- Probiotics and Fermented Foods
- Antimicrobial agents and applications
- Ultrasound and Hyperthermia Applications
- Plant-Microbe Interactions and Immunity
- Nanoplatforms for cancer theranostics
- Antimicrobial Resistance in Staphylococcus
- Plant Pathogenic Bacteria Studies
- Antibiotic Use and Resistance
- Microbial Natural Products and Biosynthesis
- Inhalation and Respiratory Drug Delivery
- Microbial Inactivation Methods
- Food Quality and Safety Studies
- Antibiotics Pharmacokinetics and Efficacy
- Phytochemical compounds biological activities
- Medical and Biological Ozone Research
- Gut microbiota and health
- Plant biochemistry and biosynthesis
Chinese Academy of Sciences
2023-2025
University of Chinese Academy of Sciences
2019-2025
Kunming Institute of Zoology
2019-2025
Zhejiang University
2014-2025
South China Agricultural University
2025
University of Hong Kong
2022-2024
Southwest Minzu University
2020-2024
Nantong University
2017-2024
Southwest Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
The emergence of carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa raises fears untreatable infections poses the greatest health threats. Antimicrobial peptides (AMPs) are regarded as most ideal solution to this menace. In study, a set was designed based on our previously reported peptide cathelicidin-BF-15, lead ZY4, cyclic stabilized by disulfide bridge with high stability in vivo (the half-life is 1.8 h), showed excellent activity against P. A. baumannii, including...
Inflammatory bowel disease (IBD) represents a significant challenge to global health, characterized by intestinal inflammation, impaired barrier function, and dysbiosis, with limited therapeutic options. In this study, we isolated novel strain of Bacillus subtilis (B. subtilis) observed promising effects in protecting against disruption the gut barrier. Our findings indicate that enhancement function is primarily attributed its metabolites. We identified metabolite,...
The increasing growth and severity of bacterial biofilm infections the appearance multidrug-resistant bacteria pose alarming threats to public healthcare systems, mainly due their formidable tolerance conventional antibiotics. Different from antibacterial mechanisms antibiotics, gold nanorods (AuNRs) disinfect microbes by local heating induced near-infrared (NIR) light irradiation; thus, they are potential disinfection agents. In an attempt increase biocompatibility activities AuNRs against...
The effects and mechanisms of Paenibacillus polymyxa Sx3 on growth promotion the suppression bacterial leaf blight in rice were evaluated this study. results from a plate assay indicated that inhibited 20 strains Xanthomonas oryzae pv. (Xoo). Rice seedling experiments promoted plant suppressed blight. In addition, bacteriological tests showed was able to fix nitrogen, solubilize phosphate produce indole acetic acid, indicating various may be involved by Sx3. culture filtrate P. reduced...
The appearance of multidrug-resistant bacteria and the formation bacterial biofilms have necessitated development alternative antimicrobial therapeutics. Antibiotics conjugated with or embedded in nano-drug carriers show a great potential advantage over free drugs, but mass proportion generally exceeds 90% nano-drug, resulting low drug loading limited therapeutic output. Herein, we fabricated nanocarrier using antibiotics as building blocks, minimizing use carrier materials, significantly...
Candida albicans is a human opportunistic pathogen that causes superficial and life-threatening infections. An important reason for the failure of current antifungal drugs related to biofilm formation, mostly associated with implanted medical devices. The present study investigated synergistic efficacy low-frequency low-intensity ultrasound combined amphotericin B (AmB)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (AmB-NPs) against C. biofilms. AmB-NPs were prepared by...
Vanillic acid (VA) is a flavoring agent found in edible plants and fruits. Few recent studies exhibited robust antibacterial activity of VA against several pathogen microorganisms. However, little was reported about the effect on carbapenem-resistant Enterobacter cloacae (CREC). The purpose current study to assess vitro antimicrobial antibiofilm activities CREC. Here, minimum inhibitory concentrations (MIC) CREC determined via gradient diffusion method. Furthermore, mode elucidated by...
To evaluate the antimicrobial effect of paeoniflorin against carbapenem-resistant Klebsiella pneumoniae (CRKP).Minimum inhibitory concentration (MIC) CRKP was determined by agar dilution method. Changes in intracellular ATP concentration, pH (pHin), cell membrane potential and integrity were investigated to assess influence on damage. Additionally, alterations structure cells damage within biofilms examined. The results indicated that effective at MIC 1·2 mg ml-1 . Paeoniflorin destroyed...
Vulvovaginal candidiasis (VVC) is a mucosal infection of the female lower genital tract for which treatment using conventional antifungal drugs shows limited effectiveness. Herein, amphotericin B-loaded poly(lactic-co-glycolic acid)-polyethylene glycol (PLGA-PEG) nanoparticles (AmB-NPs) were fabricated and combined with low intensity ultrasound (US) to mediate AmB-NPs intravaginal drug delivery achieve productive synergistic activity in rabbit model VVC.Polymeric by double emulsion method...
Antibiotic resistance is a global threat. Antimicrobial peptides (AMPs) are highly desirable to treat multidrug-resistant pathogen infection. However, few AMPs clinically available, due high cost, instability, and poor selectivity. Here, ultrashort (2–3 residues with an N-terminal cysteine) designed assembled as gold nanoparticles. Au–S conjugation size restrict nonspecific reactions peptide orientation, thus concentrating positively charged on the surface. The nanostructured assemblies...
Tuberculosis is a chronic infectious disease, the treatment of which challenging due to formation cellulose-containing biofilms by Mycobacterium tuberculosis (MTB). Herein, composite nanoparticle loaded with cellulase (CL) and levofloxacin (LEV) (CL@LEV-NPs) was fabricated then combined ultrasound (US) irradiation promote chemotherapy sonodynamic antimicrobial effects on Bacillus Calmette-Guérin bacteria (BCG, mode MTB) biofilms. The CL@LEV-NPs containing polylactic acid-glycolic acid (PLGA)...
The aim of this study was to evaluate the antagonistic activity halotolerant bacteria against rice brown stripe pathogen Acidovorax oryzae.
Abstract Purpose Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis ( Mtb ), which often parasites in macrophages. This study performed to investigate the bactericidal effect and underlying mechanisms of low-frequency low-intensity ultrasound (LFLIU) combined with levofloxacin-loaded PLGA nanoparticles (LEV-NPs) on M. smegmatis (a surrogate ) Methods results The LEV-NPs were prepared using double emulsification method. average diameter, zeta potential,...
Sanguinarine, a plant-derived benzophenanthridine alkaloid, was studied in terms of its anti-biofilm effects against carbapenem-resistant Serratia marcescens (CRSM). Minimum inhibitory concentrations (MICs) and cell membrane integrity were measured to investigate the antimicrobial mechanism sanguinarine. Additionally, extent biofilm formation by CRSM exposed sanguinarine crystal violet staining visualized via field emission scanning electron microscopy confocal laser microscopy. Sanguinarine...
The NanoCoulter Counter provided reliable evidence for the assessment of different EVs isolation method, which contributed to development EV-based disease biomarkers and treatments.