A5034358377- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Cell Adhesion Molecules Research
- Neutropenia and Cancer Infections
- Eosinophilic Disorders and Syndromes
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Hematopoietic Stem Cell Transplantation
- Parasitic Diseases Research and Treatment
- Cancer Treatment and Pharmacology
- Drug Transport and Resistance Mechanisms
- Biochemical and Molecular Research
- Chemokine receptors and signaling
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Hemoglobinopathies and Related Disorders
University of Pisa
2011-2021
Ospedale Santa Chiara
1989-2019
Rochester Institute of Technology
2009
The University of Texas MD Anderson Cancer Center
2009
Health First
1991
Istituto di Ematologia di Bologna
1990
Institute of Pharmacology
1985
ABSTRACT By directly suppressing the function of certain immune cell subsets and by stimulating other populations related to immunopathology, parasite-derived substances play an important role in chronic establishment parasitic disease. Our objective was twofold: (i) investigate further Echinococcus granulosus antigen B (AgB) human early inflammatory response determining its effect on polymorphonuclear (PMN) random migration, chemotaxis, oxidative metabolism (ii) determine action acquired...
Abstract Background: Numerous studies have reported on the immunophenotype of plasma cells (PCs) in monoclonal gammopathy undetermined significance (MGUS) and cell myeloma (PCM), but very few examined normal PCs. In this study, an objective definition range expression for each antigen was found control Using these new ranges (new method) is different from using a static 20% PCs cut‐off all antigens as described literature (traditional method). These newly calculated were applied to our data,...
Abstract Aspergillus fumigatus (AF) is a ubiquitous mold and the most common cause of invasive aspergillosis (IA) in immunocompromised patients. In stem cell transplant recipients, IA now occurs frequently setting therapy with corticosteroids, including methylprednisolone (MP). We showed previously that gliotoxin (GT), an AF-derived mycotoxin, induces apoptosis monocytes dendritic cells, resulting suppression AF-specific T responses. examined ability GT to induce polymorphonuclear leukocytes...
Although cancers are characterized by the deregulation of multiple signalling pathways, most current anticancer therapies involve modulation a single target. Because enormous biological diversity cancer, strategic combination agents targeted against critical those alterations is needed. Due to their complex nature, plant products interact with numerous targets and influence several biochemical molecular cascades. The interest in further development botanical drugs has been increasing...
Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not other lymphomas. The digital droplet PCR (dd-PCR) molecular technique that, without standard references, able to accurately quantitate DNA mutations. ddPCR could be an useful instrument detection of B-RAFV600E in HCL, minimal residual disease monitoring fundamental planning patients-targeted treatment era new anti-CD20...
Summary The worldwide problem of chronic Echinococcus granulosus disease calls for new parasite-derived immunomodulatory molecules. By screening an E. cDNA library with IgG4 from patients active cystic echinococcosis, we identified a that encodes predicted partial protein immunofluorescence studies localized in the protoscolex tegument and on germinal layer cyst wall. We named this EgTeg because 105 amino acid sequence scored highest against family Schistosoma tegumental proteins. Evaluating...
T-cell antigen expression can be observed in B-cell non-Hodgkin lymphoma (B-NHL). Although CD5 is expressed chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other antigens less common. This article reports a retrospective multicenter analysis which flow cytometry was used to evaluate aberrant CD8 on pathologic B cells 951 bone marrow samples from patients with various types B-NHL. In total 18 patients, coexpressed: 10 had B-CLL; 1, small (SLL); marginal zone...
We have developed a new statistical diagnostic model that examines the correlation between immunophenotype and clonality as detected by flow cytometry (FC) histology, defining role of FC in multiple myeloma (MM). The 192 bone marrow samples from patients control subjects were studied for routine analysis MM; minimum 100 plasma cells (PCs) analyzed each patient sample. A direct 7- or 8-color method was applied to study PCs, utilizing FACSCanto II (BD Biosciences, San Jose, CA). Samples...
Abstract Cold atmospheric plasma (CAP) has received attention as a potential anticancer strategy. In this study, culture medium was exposed to microsecond‐pulsed dielectric barrier discharge jet produce plasma‐activated (PAM). On the T‐lymphoblastic cell line, PAM induced apoptosis through activation of intrinsic pathway and inhibited cell‐cycle progression. The use scavengers N ‐acetylcysteine or O ‐phenantroline significantly decreased proapoptotic activity. genetic impact on TK6 cells...
Sulforaphane is a dietary isothiocyanate found in cruciferous vegetables showing antileukemic activity. With the purpose of extending potential clinical impact sulforaphane oncological field, we investigated effect on blasts from patients affected by different types leukemia and, taking into account intrinsically hypoxic nature bone marrow, cell line (REH) maintained conditions. In particular, tested with chronic lymphocytic leukemia, acute myeloid T-cell lymphoblastic B-cell and blastic NK...
Oral mucositis is an important side effect of hematopoietic stem cell transplantation (HCST), mainly due to toxicity conditioning regimens. It produces significant pain and morbidity. The present study reports a prospective, randomized, non-blinded testing the efficacy new mouthwash, called Baxidil Onco(®) (Sanitas Farmaceutici Srl, Tortona, Italy) in 60 hematologic patients undergoing HCST (28 autologous, 32 allogeneic). Onco(®), used three times day from Day -1 +30, addition standard...
Serum levels of total cholesterol and triglycerides were studied in 202 patients affected by various hematological malignancies at the time diagnosis. A hypocholesterolemia was found 44% lymphoproliferative diseases acute lymphoblastic leukemia, with an evident correlation clinical stage (5.7% nonadvanced stages, 67.8% advanced stages). In chronic myeloproliferative diseases, overall incidence 71%. particular, a greater low values myeloid leukemia idiopathic myelofibrosis than polycythemia...
Abstract Neutrophil functions can be modified by Recombinant human G‐CSF (rhG‐CSF) treatment, with divergent effects on phagocytosis, motility, bactericidal activity, and surface molecule expression. morphology is treatment filgrastim (the nonglycosylated form of rhG‐CSF), while it not affected lenograstim glycosylated type rhG‐CSF). Little information available about actin polymerization in neutrophils from subjects treated the two types rhG‐CSF. In current paper we evaluated groups donors...
Background Maintenance treatment after autologous bone marrow transplantation in multiple myeloma improves the outcome of patients. We designed a phase II clinical trial to evaluate with IL2 and zoledronate Methods Patients histologically proven diagnosis become eligible if achieved very good partial remission samples 3 months from transplantation. was administered day 1 7. In first cycle, daily dose 2 × 10 6 IU, whereas, subsequent ones progressively escalated, +25% increases at each until...
<i>Aim:</i> We evaluated the effect of 45-kD protein <i>Trichinella spiralis</i> (gp45), purified by affinity chromatography, on random migration and chemotaxis, oxidative metabolism human neutrophils CD11b upregulation induced formyl-methionyl-leucyl-phenylalanine (f-MLP). <i>Methods:</i> Donor incubated with different amounts gp45 (0.5, 1, 1.5, 2 μg/ml) or buffer means a special technique image analysis, chemiluminescence response to f-MLP phorbol...